Neurophysiological effects of a special extract of Cyperus esculentus L. (Cyperol)


Neurophysiological effects of a special extract of Cyperus esculentus L. (Cyperol)


Wiebe JC., López-Ríos L., Vega-Morales T., Pérez-Machín R., Mateos CJ., Gericke N.

Nektium Pharma, Agüimes, Spain.


The tuberous rhizomes of Cyperus esculentus L. have been used as a food by hunter-gatherer and agricultural societies for millennia. Varieties and selections of the plant are cultivated in southern Europe, north Africa and west Africa. There is popular food and beverage uses, and traditional medicinal uses suggest that the “tubers” may have functional food potential.

The first standardized extract of Cyperus esculentus, Cyperol, has been developed and commercialized. In order to characterize the central nervous system activity of this extract a series of neurophysiological studies were undertaken in-vitro, in-vivo and in a pilot clinical study.

The results of the studies indicate that Cyperol induces changes in brain electrical activity (EEG), demonstrating that bioactive compounds from the extract are absorbed, are bioavailable, and that these compounds or their metabolites cross the blood brain barrier. Taken overall, the results of the reported studies indicate calming activity without sedation. This extract does indeed have functional food potential and could be used to maintain a calm state of mind while dealing with cognitively demanding work. Preliminary indications suggest that the extract may have anxiolytic potential which should be explored in future clinical studies.


Keywords: Cyperus esculentus, Cyperol, stress, calm, anxiolytic, non-sedating


Free Full-text PDF


How to cite this article:
Wiebe JC., López-Ríos L., Vega-Morales T., Pérez-Machín R., Mateos CJ., Gericke N.. Neurophysiological effects of a special extract of Cyperus esculentus L. (Cyperol). Journal of Herbal Medicine Research, 2019,4:34. DOI:10.28933/jhmr-2019-09-2705


References:

1. Linssen, J. P. H., Cozijnsen, J. L. & Pilnik, W. Chufa (cyperus esculentus): A new source of dietary fibre. J. Sci. Food Agric. 49, 291–296 (1989).
2. Maduka, N. & Ire, F. S. Tigernut Plant and Useful Application of Tigernut Tubers (Cype-rus esculentus) – A Review. Curr. J. Appl. Sci. Technol. 29, 1–23 (2018).
3. Negbi, M. A sweetmeat plant, a perfume plant and their weedy relatives: A chapter in the his-tory ofCyperus esculentus L. andC. rotundus L. Econ. Bot. 46, 64–71 (1992).
4. Moens, M.-F. & Manniche, L. An Ancient Egyptian Herbal. J. Am. Orient. Soc. 112, 541 (2006).
5. Watt, J. M. & Breyer-Brandwijk, M. G. The medicinal and poisonous plants of southern and eastern Africa: being an … – John Mitchell Watt, Maria Gerdina Breyer-Brandwijk – Goo-gle Libros. (1962).
6. McClendon, J. F. Some American Plants Con-sidered as Sources of Vitamines, and as Parts of a Diet Favorable to the Preservation of the Teeth’. J. Dent. Res. 3, 279–295 (1921).
7. Morton, J. F. Principal Wild Food Plants of the United States: Excluding Alaska and Hawaii. Economic Botany 17, 319–330 (1963).
8. Defelice, M. S. Yellow Nutsedge Cyperus es-culentus L.—Snack Food of the Gods. Weed Technol. 16, 901–907 (2002).
9. Christian, E. P. et al. EEG-β/γ spectral power elevation in rat: a translatable biomarker elici-ted by GABA(Aα2/3)-positive allosteric modu-lators at nonsedating anxiolytic doses. J. Neu-rophysiol. 113, 116–31 (2015).
10. Alonso, J. F. et al. Evaluation of multiple com-parison correction procedures in drug as-sessment studies using LORETA maps. Med. Biol. Eng. Comput. 53, 1011–1023 (2015).
11. Dimpfel, W. Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG). Eur. Neuropsychopharmacol. 15, 673–682 (2005).
12. Dimpfel, W. & Schober, F. Norepinephrine, EEG theta waves and sedation. Brain Phar-macol. 1, 89–87 (2001).
13. Dimpfel, W. Pharmacological Modulation of Dopaminergic Brain Activity and Its Reflection in Spectral Frequencies of the Rat Electrop-harmacogram. Neuropsychobiology 58, 178–186 (2008).
14. Dimpfel, W. Preclinical data base of pharma-co-specific rat EEG fingerprints (tele-stereo-EEG). Eur. J. Med. Res. 8, 199–207 (2003).
15. Dimpfel, W., Dalhoff, A., Hofmann, W. & Schlüter, G. Electrically evoked potentials in the rat hippocampus slice in the presence of aminophylline alone and in combination with quinolones. Eur. Neuropsychopharmacol. 4, 151–6 (1994).
16. Dimpfel, W., Hofmann, H. C., Prohaska, A., Schober, F. & Schellenberg, R. Source densi-ty analysis of functional topographical EEG: monitoring of cognitive drug action. Eur. J. Med. Res. 1, 283–90 (1996).
17. Dimpfel, W., Gericke, N., Suliman, S. & Dipah, C. G. Psychophysiological Effects of Zembrin ® Using Quantitative EEG Source Density in Combination with Eye-Tracking in 60 Healthy Subjects. A Double-Blind, Randomized, Place-bo-Controlled, 3-Armed Study with Parallel Design. Neurosci. Med. 7, 114–132 (2016).
18. Dimpfel, W. Drug Discovery and Translational Medicine Neurophysiological Techniques Pro-vide a Holistic Approach to Saving Animals. (Verlag Books on Demand, 2015).
19. Maroon, J. & Bost, J. Review of the neurologi-cal benefits of phytocannabinoids. Surg. Neu-rol. Int. 9, 91 (2018).
20. Ali, N., Muhammad, A. & Akbar, S. A. Anxioly-tic-like activity of ethanol extract of Ganoder-ma Lucidum (Reishi) in mice. Int. J. Med. Res. Heal. Sci. 5, 57–60 (2016).
21. Matsuzaki, H. et al. Antidepressant-like ef-fects of a water-soluble extract from the cultu-re medium of Ganoderma lucidum mycelia in rats. BMC Complement. Altern. Med. 13, 370 (2013).