Research Article of Journal of Pharmaceutical Research and Reviews
Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats
Odinga, T.1,2, Nwaokezi, C.O.1
1Department of Biochemistry, Rivers state university. Nigeria;
2Department of Biochemistry, University of Port Harcourt, Rivers state, Nigeria.
This study evaluated the potentials of the seed extract of Ricinodendron heudelotii on the oxidative stress biomarkers of diabetic albino rats of the wistar strain. Diabetes mellitus was induced via intraperitoneal administration of 160 mg/ kg bodyweight Alloxan monohydrate in normal saline and confirmed after 120 hours of blood glucose level above 300mg/dl. Blood samples were collected from the animals and analyzed for Malondialdehyde, Catalase, Reduced Glutathione, Glutathione-S-transferase, Glutathione peroxidase, and Superoxide dismutase activities as biomarkers of oxidative stress. The result revealed a significant decrease at P≤0.05 in blood glucose concentration of diabetic rats with increase in the seed extract concentration, Malondialdehyde (MDA) decreased significantly in the diabetic rats while Catalase increased significantly at P≤0.05 as the extract concentration increased. Variations in Glutathione-S-transferase, Glutathione Peroxidase, Superoxide dismutase and Reduced Glutathione in comparison with control was observed. The results therefore suggests that the aqueous seed extract of Ricinodendron heudelotii has the potency to reduce glucose level and act as antioxidants against oxidative stress, hence its use therapeutically.
Keywords: Ricinodendron heudelotii, Alloxan monohydrate, Antioxidant biomarkers, Diabetes mellitus, oxidative stress.
How to cite this article:
Odinga, T., Nwaokezi, C.O. Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats. Journal of Pharmaceutical Research and Reviews, 2020; 4:19. DOI: 10.28933/jprr-2019-11-1905
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