Different Methodology for Preparation of NLCs – A Review


Different Methodology for Preparation of NLCs – A Review


R.C.Doijad , S.V.Salve, Patil Anup

KIMSDTU’s Krishna Institute of Pharmacy, Karad, Maharashtra, India


Journal of Pharmaceutical Research and Reviews

Nanotechnology in the formulation developed exponentially, the main objective or the basic aim has been on therapeutic undertaking, particularly for targetted drug therapy. Nanocarriers are at forefront of the rapidly developing field of nanotechnology with several potential applications in novel drug delivery, also in clinical medicines and research. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in medicinal formulation and other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutic effect. The incorporation of drugs into nanocarriers offers a new prototype in drug delivery that could be used for different levels of drug targeting. Nanostructure lipid carriers have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceutical consignment. Today’s new generation of nanostructured lipid carriers (NLCs) consisting of a lipid matrix with a special nanostructured has been developed. This nanostructure improves drug loading and firmly incorporates the drug during storage. The present review gives insights on the definitions and different techniques of preparation of NLCs.


Keywords: Nanotechnology, Solid lipid nanoparticles, Nanocarriers, nanostructured lipid carriers, novel drug delivery

Free Full-text PDF


How to cite this article:
R.C.Doijad , S.V.Salve, Patil Anup. Different Methodology for Preparation of NLCs – A Review. Journal of Pharmaceutical Research and Reviews, 2019; 3:18


References:

1. O’driscoll CM, Griffin BT. (2008). Biopharmaceutical challenges associated with drugs with low aqueous solubility–the potential impact of lipidbased formulations. Adv Drug Deliv Rev 60:617–24.
2. Aditya NP, Macedo AS, Doktorovova S, et al. (2014). Development and evaluation of lipid nanocarriers for quercetin delivery: a comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE). Food Sci Technol 59:115–21.
3. Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. Eur J Pharm Biopharm 2000; 50: 161-77.
4. Jores K, Mehnert W, Mäder K. Physicochemical investigations on solid lipid nanoparticles and on oil-loaded solid lipid nanoparticles: a nuclear magnetic resonance and electron spin resonance study. Pharm Res 2003; 20: 1274-83.
5. Müller RH, Radtke M, Wissing SA. Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 2002; 242: 121-8.
6. Jenning V, Thünemann AF, Gohla SH. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int J Pharm 2000: 199: 167-77.
7. Constantinides PP, Tustian A, Kessler DR. Tocol emulsions for drug solubilization and parenteral delivery. Adv Drug Deliv Rev 2004; 56: 1243-55.
8. Tsai MJ, Wu PC, Huang YB, et al. Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting. Int J Pharm 2012; 423: 461-70.
9. Averina ES, Seewald G, Müller RH, Radnaeva LD, Popov DV. Nanostructured lipid carriers (NLC) on the basis of Siberian pine (Pinus sibirica) seed oil. Pharmazie 2010; 65: 25-31.
10. Liu, P; Kurihara-Bergstrom, T and Good, WR (1991), “Cotransport of estradiol and ethanol through human skin in vitro: understanding the permeant/enhancer flux relationship”, Pharm Res, Vol. 8: 938-944.
11. Mishra B, Patel BB, Tiwari S. Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine: NMB2010; 6 Supply 1:e9-e24.
12. Ekambaram P, Sathali AH, Priyanka K. Solid Lipid Nanoparticles: A Review. Scientific Reviews and Chemical. Communication2012; 2 Suppl 1:80-102.
13. Mehnert, W., Mäder, K., Solid lipid nanoparticles: production, characterization and applications, Adv Drug Deliv Rev, 2001, 47(2-3): p. 165-96.
14. Wissing, S., Kayser, O., Müller, R. H., Solid lipid nanoparticles for parenteral drug delivery, Adv Drug Deliv Rev, 2004, 56: p. 1257-72.
15. Liedtke, S., Wissing, S., Muller, R.H., Mader, K., Influence of high pressure homogenisation equipment on nanodispersions characteristics, Int J Pharm, 2000, 196(2): p. 183-5.
16. Lippacher A., Muller R.H., Mader K.: Investigation on the viscoelastic properties of lipid based colloidal drug carriers. Int. J. Int. J. Pharm. 2000, 196, 227-230.
17. Mehnert W., Mäder K.: Solid lipid nanoparticles Production, characterization and applications. Advanced Drug Delivery Reviews 2001, 47, 165-196.
18. Yadav V, AlokMahor S, Alok S, AmitaVerma A, Kumar N, Kumar S. Solid lipid nanoparticles (sln): formulation by high pressure homogenization. World J Pharm Pharm Sci 2014;3(11):1200-13.
19. Sunil PC, Vimal K. Production Techniques of Lipid Nanoparticles: A Review. Res J Pharm Bio Chem Sci 2012;3(3):525.
20. Silva AC, Gonzalez-Mira E, Garcia ML, Egea MA, Fonseca J, Silva R, et al. Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (sln): High pressure homogenization versus ultrasound. Colloids Surf B Biointerfaces 2011;86(1):158-65. doi: 10.1016/j.colsurfb.2011.03.035
21. Mehnert W, Mader K. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 2001;47(2-3):165-96.Mehnert W, Mader K. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 2001; 47(2-3):165-96.
22. Kamble MS, Vaidya KK, Bhosale AV, Chaudhari PD. Solid lipid nanoparticles and nanostructured lipid carriers–an overview. Int J Pharm chem Biol Sci 2012;2(4):681-91.
23. Parhi R, Suresh P. Production of Solid Lipid Nanoparticles-Drug Loading and Release Mechanism. J Chem Pharm Res 2010;2(1):211-27.
24. Eldem T, Speiser P, Hincal A. Optimization of spray-dried and congealed lipid microparticles and characterization of their surface morphology by scanning electron microscopy. Pharm Res 1991;8:47-54.
25. Speiser P. Lipidnanopellets als Tragersystem fur Arzneimittel zur peroralem Anwendung. European Patent No. EP 0167825; 1990.
26. Puglia, C., Blasi, P., Rizza, L., Schoubben, A., Bonina, F., Rossi, C., Ricci, M., Lipid nanoparticles for prolonged topical delivery: An in vitro and in vivo investigation, Int J Pharm, 2008, 357(1-2): p. 295-304.
27. Priano, L., Esposti, D., Esposti, R., Castagna, G., De Medici, C., Fraschini, F., Gasco, M.R., Mauro, A., Solid lipid nanoparticles incorporating melatonin as new model for sustained oral and transdermal delivery systems, J Nanosci Nanotechnol, 2007, 7(10): p. 3596-601.
28. Gasco, M.R., Solid lipid nanspheres from warm microemuslion, Pharm Technol Eur, 1997, 9: p. 32-42.
29. Siekmann B, Westesen K. Investigations on solid lipid nanoparticles prepared by precipitation in o/w emulsions. Eur J Pharm Biopharm 1996; 43:104-9.
30. Varsha Gharge, Pravin Pawar. Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System. International Journal of Ophthalmology & Visual Science. Vol. 2, No. 4, 2017, pp. 98-105.
31. Kh. Hussan R: Nanoemulsion as a Novel Transdermal Drug Delivery System. International Journal of Pharmaceutical Sciences and Research, 2011; Vol. 2(8):1938-1946.
32. Shahgaldian P, Silva ED, Coleman AW, Rather B, Zaworotko MJ. Int J Pharm 2003; 253: 23–38.
33. Wissing SA, Kayser O, Muller RH. Ad Drug Deliv Rev 2004; 56: 1257– 1272.
34. R. Cortesi, E. Esposito, G. Luca,C.Nastruzzi.Production of lipospheres as carriers for bioactive compounds. Biomaterials, 23, 2002, 2283-2294.
35. Trotta, M., Debernardi, F., Caputo, O. Preparation of Solid Lipid Nanoparticles by a solvent emulsification-diffusion technique. Int J Pharm. 2003, 257, 153-160.
36. Devarajan V and Ravichandran V: Nanoemulsions: As Modified Drug Delivery Tool. International Journal of Comprehensive Pharmacy, 2011, 4 (01):1-6.
37. Hadgraft, J (2001), “Skin: the final frontier”, Int J Pharm, Vol. 224, 1-18
38. Raj Kumar Mishra et al., A Review Article: On Nanoemulsion, World Journal of Pharmacy and Pharmaceutical Sciences, Vol 3, Issue 9, 2014, 258-274.