Open Journal of Gastroenterology and Hepatology


Prevalence, clinical characteristics and related mortality of cirrhosis in a tertiary hospital setting in Sub Saharan Africa

Research Article of Open Journal of Gastroenterology and Hepatology Prevalence, clinical characteristics and related mortality of cirrhosis in a tertiary hospital setting in Sub Saharan Africa Mathurin Kowo1,2, Larissa Pessidjo1, Charifa Fouwou Njoya1, Larry Tangie Ngek1, Larissa Tangan1, Christelle Nguemo1, Marthe Alogo1, Larissa Ntsama1, 2, Oudou Njoya1, Firmin Ankouane Andoulo1, 2 1Departement of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon. 2Internal Medicine unit, Yaounde University Teaching Hospital Yaoundé, Cameroon. Background: Published data on the prevalence and mortality associated to cirrhosis is rare in Cameroon. The aim of this study was to determine the prevalence, clinical and para clinical characteristics and associated mortality of cirrhosis at the Yaounde University Teaching Hospital (YUTH), Cameroon. Methods: Files of patient’s followed up or admitted for cirrhosis at the YUTH between June 1st 2016 and June 30th 2018 were reviewed. The diagnosis of cirrhosis was made based on clinical, biological, ultrasonographic and/or endoscopic signs of portal hypertension and chronic liver failure. In other to establish the cause of cirrhosis, markers of documented chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) was sought in the file of the patients and if not present, hepatitis C antibody and hepatitis B surface antigen testing were requested. In patients negative for HBV and HCV markers, alcohol intake was considered as a cause of cirrhosis in someone who have been consuming more than 30 g/day (for males) or more than 20 g/day (for females) of alcohol. Data analyses were performed using Epi info V 3.5.4. Results: During the period of study, 1748 patients were admitted in the internal medicine unit among which 117 had cirrhosis giving a prevalence of 6.7%. There were 67 males (57.3%) and 50 females (42.7%). The mean age of patients was 51 +/- 19.862 years. Patients with ...

Usefulness of Castor Oil and Elobixibat and Lactulose and ascorbic Aid for Bowel Preparation for Colon Capsule Endoscopy-Initial examination

Research Article of Open Journal of Gastroenterology and Hepatology Usefulness of Castor Oil and Elobixibat and Lactulose and ascorbic Aid for Bowel Preparation for Colon Capsule Endoscopy-Initial examination Naoki Hotta Department of Internal Medicine, Division of Gastroenterology, Masuko Memorial Hospital, Aichi, Japan. Colon capsule endoscopy was approved for reimbursement under the national health insurance system of Japan in 2014. However, the capsule excretion rate after recommended bowel preparation reportedly ranges from 70% to 90%, and administration of boosters is also necessary. The caster oil-based booster had an emission rate of 97%, but required a total water content of 3L. Considering whether it is possible to popularize colon capsule endoscopy by reducing the amount of water, including dialysis patients with water restrictions, we will consider whether the capsule discharge rate can be improved by combining new laxatives. Keywords: Castor Oil; Elobixibat; Ascorbic Aid; Colon Capsule Endoscopy ...

Pure alphafetoprotein producing neuroendocrine carcinoma of the stomach: A case report

Case Report of Open Journal of Gastroenterology and Hepatology Pure alphafetoprotein producing neuroendocrine carcinoma of the stomach: A case report Chen-Wei Chu1, Chien-ho Tsai2, Yu-Huan Huang3, Chun-I Tsai4, Swei-hsiung H Tsung5 1.Department of Medicine, Taipei Veterans General Hospital, Yuanshan branch, Yuanshan, Yilan, Taiwan. 2.Deparment of surgery, National Yang-Ming University Hospital, Yilan.Taiwan. 3.Department of Nursing, National Yang-Ming University Hospital, Yilan, Taiwan 4.Chun-I Tsai Medical Clinic. Yilan, Taiwan. 5.Department of Pathology, St Mary’s Hospital, Loudong, Yilan, Taiwan Alpha-fetoprotein-producing gastric carcinoma (AFP-GC) is a rare malignant tumor, and has been regarded as a distinct category because of its particularly aggressive biological behavior and poor patient prognosis. In the literature, AFP-GC was never reported in neuroendocrine carcinoma of the stomach. In this article, we described a 60-year old man who sought medical attention because of epigastric pain and poor appetite. His laboratory data were within normal limits except for elevated serum level of alpha-fetoprotein. He was found to have an ulcer on gastroscopic examination which led to the final diagnosis of AFP producing neuroendocrine carcinoma of the stomach. He underwent a radical gastrectomy followed by chemotherapy using leucovorin and 5-fluorouracil.His disease was brought under remission for only six months before radiological recurrence occurred. His recurrent disease was treated with irinotican plus cisplatin without a significant response. His prognosis looked grave. We reported the first case of AFP producing gastric neuroendocrine carcinoma to share our experience. Keywords: gastric cancer. Alpha-fetoprotein. Neuroendocrine carcinoma. Chemotherapy. Immunohistochemical stainings. Radiological recurrence ...

Non-alcoholic Fatty Liver Disease among patients with Inflammatory Bowel Disease in Qatar: Prevalence and Risk Factors

Research Article of Open Journal of Gastroenterology and Hepatology Non-alcoholic Fatty Liver Disease among patients with Inflammatory Bowel Disease in Qatar: Prevalence and Risk Factors Dr. Muneera Al-Mohannadi1, Dr. Prem Chandra2, Dr. Betsy Varughese1, Dr. Abdulwahab Hamid1, Dr. Ahmed Badi1, Dr. Saad Al Kaabi1, Dr. Rafie Yakoob1, Dr. Khalid Al-Ejji1, Dr. Khaleel Sultan1, Dr. Adham A. H. Darweesh3, Nevin Abunahia1 and Dr. Moutaz Derbala4 1Gastroenterology & Hepatology, Hamad Medical Corporation, 2Research Affairs, Hamad Medical Corporation, 3Radiology, Hamad Medical Corporation, 4Prof., Hamad Medical Corporation, Doha. Qatar. Background: Non-alcoholic fatty liver disease (NAFLD) has been increasingly identified in patients with inflammatory bowel disease (IBD), though metabolic risk factors for NAFLD are less frequent in IBD patients. Qatar is among countries characterized by the high prevalence of fatty liver. We aimed to characterize NAFLD in IBD patients and to determine factors associated with its severity. Methods: A retrospective observational study was conducted to estimate the prevalence of NAFLD in all IBD patients followed at Hamad hospital, Doha, Qatar between January 2008 to December 2017. The associations between two or more qualitative variables were assessed using χ2-test and quantitative data between two independent groups were analyzed using the unpaired t-test. Multivariate logistic regression analysis was applied to determine the predictive values of each predictor for NAFLD among IBD patients. Results: Among 913 IBD patients with a mean age of 36.9±13.2 years and BMI 26.9±6.1; 550 were males (60.2%), 383(41.9%) with Crohn’s disease and 530 (58.1%) with Ulcerative colitis. 24 (22.2%) patients had severe steatosis. The overall prevalence of NAFLD was 11.8% (95% CI 9.9, 14.1) and does not differ significantly between CD and UC patients (11.7% vs 11.9%; P=0.949).Patients who developed NAFLD were older at baseline (42.6±12.5 vs 36.2±13.1 years; P<0.001), had higher BMI (29.3±5.7 vs 26.6±6.1; P<0.001) and higher prevalence of diabetes (26% ...

Dr. Mohammed Naeem
Chair, Patient Safety Reporting/Consultant Pediatric Intensivist/ Head PICU (A)/ Assistant Professor, Dept. of Pediatrics. Ministry National Guard Health Affairs Riyadh, Saudi Arabia

Dr Toru Ishikawa
Gastroenterology, Saiseikai Niigata Daini Hospital

Dr. George Paraskevas
Associate Professor of Anatomy Orthopedic Surgeon, Department of AnatomyMedical School, Aristotle University of Thessaloniki, Post Box: 300, Post Code: 54124, Thessaloniki, Greece

Dr. Mahaboob Vali Shaik
Assistant Professor/Senior Scientist, Department of Genetics & stem cell Research, Narayana Medical College & Hospitals

Dr. Ifeadike Chigozie Ozoemena
Associate Professor, Department of Community Medicine, Faculty of Medicine, Nnamdi Azikiwe University

Dr. Eduardo de Moura GH
Professor, niversity of São Paulo School of Medicine, São Paulo, Brazil

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1.Gomes, K.K.L; Lima, A.A.F. Living Style of Diabetic Patients Type.Open Journal of Gastroenterology and Hepatology, 2018, 1:5. DOI:10.28933/ojgh-2018-05-1005

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