Open Journal of Gastroenterology and Hepatology

Pure alphafetoprotein producing neuroendocrine carcinoma of the stomach: A case report

Case Report of Open Journal of Gastroenterology and Hepatology Pure alphafetoprotein producing neuroendocrine carcinoma of the stomach: A case report Chen-Wei Chu1, Chien-ho Tsai2, Yu-Huan Huang3, Chun-I Tsai4, Swei-hsiung H Tsung5 1.Department of Medicine, Taipei Veterans General Hospital, Yuanshan branch, Yuanshan, Yilan, Taiwan. 2.Deparment of surgery, National Yang-Ming University Hospital, Yilan.Taiwan. 3.Department of Nursing, National Yang-Ming University Hospital, Yilan, Taiwan 4.Chun-I Tsai Medical Clinic. Yilan, Taiwan. 5.Department of Pathology, St Mary’s Hospital, Loudong, Yilan, Taiwan Alpha-fetoprotein-producing gastric carcinoma (AFP-GC) is a rare malignant tumor, and has been regarded as a distinct category because of its particularly aggressive biological behavior and poor patient prognosis. In the literature, AFP-GC was never reported in neuroendocrine carcinoma of the stomach. In this article, we described a 60-year old man who sought medical attention because of epigastric pain and poor appetite. His laboratory data were within normal limits except for elevated serum level of alpha-fetoprotein. He was found to have an ulcer on gastroscopic examination which led to the final diagnosis of AFP producing neuroendocrine carcinoma of the stomach. He underwent a radical gastrectomy followed by chemotherapy using leucovorin and 5-fluorouracil.His disease was brought under remission for only six months before radiological recurrence occurred. His recurrent disease was treated with irinotican plus cisplatin without a significant response. His prognosis looked grave. We reported the first case of AFP producing gastric neuroendocrine carcinoma to share our experience. Keywords: gastric cancer. Alpha-fetoprotein. Neuroendocrine carcinoma. Chemotherapy. Immunohistochemical stainings. Radiological recurrence ...

Non-alcoholic Fatty Liver Disease among patients with Inflammatory Bowel Disease in Qatar: Prevalence and Risk Factors

Research Article of Open Journal of Gastroenterology and Hepatology Non-alcoholic Fatty Liver Disease among patients with Inflammatory Bowel Disease in Qatar: Prevalence and Risk Factors Dr. Muneera Al-Mohannadi1, Dr. Prem Chandra2, Dr. Betsy Varughese1, Dr. Abdulwahab Hamid1, Dr. Ahmed Badi1, Dr. Saad Al Kaabi1, Dr. Rafie Yakoob1, Dr. Khalid Al-Ejji1, Dr. Khaleel Sultan1, Dr. Adham A. H. Darweesh3, Nevin Abunahia1 and Dr. Moutaz Derbala4 1Gastroenterology & Hepatology, Hamad Medical Corporation, 2Research Affairs, Hamad Medical Corporation, 3Radiology, Hamad Medical Corporation, 4Prof., Hamad Medical Corporation, Doha. Qatar. Background: Non-alcoholic fatty liver disease (NAFLD) has been increasingly identified in patients with inflammatory bowel disease (IBD), though metabolic risk factors for NAFLD are less frequent in IBD patients. Qatar is among countries characterized by the high prevalence of fatty liver. We aimed to characterize NAFLD in IBD patients and to determine factors associated with its severity. Methods: A retrospective observational study was conducted to estimate the prevalence of NAFLD in all IBD patients followed at Hamad hospital, Doha, Qatar between January 2008 to December 2017. The associations between two or more qualitative variables were assessed using χ2-test and quantitative data between two independent groups were analyzed using the unpaired t-test. Multivariate logistic regression analysis was applied to determine the predictive values of each predictor for NAFLD among IBD patients. Results: Among 913 IBD patients with a mean age of 36.9±13.2 years and BMI 26.9±6.1; 550 were males (60.2%), 383(41.9%) with Crohn’s disease and 530 (58.1%) with Ulcerative colitis. 24 (22.2%) patients had severe steatosis. The overall prevalence of NAFLD was 11.8% (95% CI 9.9, 14.1) and does not differ significantly between CD and UC patients (11.7% vs 11.9%; P=0.949).Patients who developed NAFLD were older at baseline (42.6±12.5 vs 36.2±13.1 years; P<0.001), had higher BMI (29.3±5.7 vs 26.6±6.1; P<0.001) and higher prevalence of diabetes (26% ...

Endoscopic Outcome of non complicated Gastric Ulcer following Standard Medical Treatment in sub-Saharan African Population

Research Article of Open Journal of Gastroenterology and Hepatology Endoscopic Outcome of non complicated Gastric Ulcer following Standard Medical Treatment in sub-Saharan African Population Kowo MP1, Essouma M1, Ndjitoyap Ndam AW1, Wembe Sop BD2, Kenfack GU1, Guekam Ouamba P2, Ndjitoyap Ndam EC1, Njoya O1, Ankouane Andoulo F1 1Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon; 2Université des Montagnes Banganté Cameroon Background.The endoscopic outcome of gastric ulcers is not well described in sub-Saharan Africa. This study was therefore conducted in order to track the endoscopic outcome of non complicated gastric ulcers following standard medical treatment in  sub-Saharan African population. Methods.This was a prospective cohort study conducted from January to July 2018 in three tertiary healthcare centers in Yaounde (Cameroon).Gastric ulcers and gastric H. pylori infection were diagnosed and monitored by upper digestive endoscopy performed before and at least four weeks following treatment with proton pump inhibitors alone or combined with antibiotics depending on H. pylori status.  A complete case analysis was done using the SPSS software, version 21.0. p-values ≤0.05 were considered as significant. Results. Ninety-six patients (54.2% males) with a mean age of 55.3 ± 14.9 years were initially enrolled. In most patients, the ulcer frequently was unique (76%) and the antrum was the commonest localization 76 (79.2%). Among patients with H. pylori infection, the quadruple therapy was the most prescribed treatment 41 (87.2%) patients. There were 60 (62.5%) subjects lost to follow-up. Of the 36 (37.5%) patients who underwent repeat endoscopy, 26 (72.2%) had ulcer healing and 8/13 patients had successful H. pylori eradication. A delay of repeat endoscopy >8 weeks was the only predictor of non-healing of the ulcer: relative risk 0.6[95% CI: 0.3-1.08], p = 0.05. Conclusion.Ulcer healing was found in nearly 2/3 of patients and H. pylori eradication in almost ¾ of patients. This study ...

Gastric Outlet Obstruction: Transform in Etiogenesis

Research Article of Open Journal of Gastroenterology and Hepatology GASTRIC OUTLET OBSTRUCTION: TRANSFORM IN ETIOGENESIS: STUDY FROM NORTHERN RAJASTHAN ZUBIN PRADEEP SHARMA, RAVINDRA SHARMA, DIVYA SHARMA, SANTOSH YADAV Department of Gastroenterology, Aditya Hospital And Gastroenterology Centre, Rajasthan, India Objective: To determine the frequency of various etiologies of Gastric Outlet Obstruction in Northern part of Rajasthan, India. Design & Duration: Prospective study carried out from March 2018 to March 2019. Methodology: The data of all the patients who presented with the features of Gastric Outlet Obstruction during the above mentioned period was collected. This data was analyzed with specific reference to recent trends in its etiology. This change in trend was compared with other local and international studies. Results: Fifty patients were included in the study. All patients underwent upper GI endoscopy and biopsy; 40 cases were diagnosed by this method and the remaining by CT scan. Gastric carcinoma was the most common cause of Gastric Outlet Obstruction seen in 36% of the cases. The next common etiology was peptic ulcer disease which was responsible for 32% of the patients. Conclusion: The ratio between benign and malignant etiologies of Gastric Outlet Obstruction is showing a gradual change in favour of malignant lesions. This change is similar to the trends reported in the western literature. Keywords: Gastric Outlet Obstruction, etiology, Gastric Carcinoma, Peptic Ulcer disease ...

Dr. Mohammed Naeem
Chair, Patient Safety Reporting/Consultant Pediatric Intensivist/ Head PICU (A)/ Assistant Professor, Dept. of Pediatrics. Ministry National Guard Health Affairs Riyadh, Saudi Arabia

Dr Toru Ishikawa
Gastroenterology, Saiseikai Niigata Daini Hospital

Dr. George Paraskevas
Associate Professor of Anatomy Orthopedic Surgeon, Department of AnatomyMedical School, Aristotle University of Thessaloniki, Post Box: 300, Post Code: 54124, Thessaloniki, Greece

Dr. Mahaboob Vali Shaik
Assistant Professor/Senior Scientist, Department of Genetics & stem cell Research, Narayana Medical College & Hospitals

Dr. Ifeadike Chigozie Ozoemena
Associate Professor, Department of Community Medicine, Faculty of Medicine, Nnamdi Azikiwe University

Dr. Eduardo de Moura GH
Professor, niversity of São Paulo School of Medicine, São Paulo, Brazil

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