Open Journal of Gastroenterology and Hepatology


Treatment of hepatocellular carcinoma using the Smart Fusion needle navigation system: conversion from real-time 4D-echo data

Research Article of Open Journal of Gastroenterology and Hepatology Treatment of hepatocellular carcinoma using the Smart Fusion needle navigation system: conversion from real-time 4D-echo data Naoki Hotta Department of Internal medicime,division of Hepatology,Msusko Memorial Hospital, 35-28 takebashi nakamuraku-,Nagoya,aichi,Japan 453-8566 Advances in ultrasound systems have improved the accuracy of hepatocellular carcinoma (HCC) diagnosis and treatment. We have been treating HCC using real-time 4D and Live 3D-echo technologies. However, these treatment methods have drawbacks such as vibrations during puncture and a limited angle of needle insertion. To overcome these problems, systems that can display ultrasound images simultaneously with computed tomography (CT) and magnetic resonance images in a real-time manner for reference purposes have been reported. These systems have recently been equipped with a needle tip navigation system, making it possible to reliably visualize tumors and determine the needle tip position in a tumor. These developments have enabled the safe treatment of HCC. Treatment using needle navigation is performed as follows: A Canon APLIO800 ultrasound system is used with a conventional convex probe (PVT-375BT) and a micro-convex probe (PVT-382BT). The system function is known as Smart Fusion. Ultrasound images can be displayed with volume data from other modalities, such as CT and magnetic resonance imaging (MRI), in relation to the positional information using a magnetic sensor. This enables the use of CT/MRI data as reference for accurate puncture and treatment of lesions that are difficult to identify by ultrasound alone. Axis alignment is also completed by displaying the xiphoid process on a CT image and having the system learn the orientation of the probe placed perpendicular to the body axis. Then, landmark alignment is performed and fine-adjusted by aligning a target point near the lesion with the same point as displayed on CT (Fig. 1). Case presentation A 7x-year-old woman was found to ...

Prevalence of HBsAg and anti-HCV antibodies during a screening campaign in August 2019

Research Article of Open Journal of Gastroenterology and Hepatology Prevalence of HBsAg and anti-HCV antibodies during a screening campaign in August 2019 Mathurin Pierre Kowo1,2,3, Edgar Kenne Yimagou1, Antonin Wilson Ndjitoyap Ndam1, Charifa Fouwou Njoya1, Patricia Guekam Ouamba3, Larissa Pessidjo1, Christelle Nouboussi Nguemo1, Akhenaton Dime Ngock1, Larissa Ntsama1, Larry Tangie Ngek1, Oudou Njoya1,2,3 1Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Cameroon; 2Research Laboratory on viral Hepatitis and Health Communication, University of Yaounde 1, Cameroon, 3University Teaching Hospital of Yaounde Introduction: Hepatitis B (HBV) and C (HCV) virus infections represent a major public health problem, with significant mortality and morbidity worldwide. The aim of this study was to determine the prevalence of HBsAg and anti-HCV antibodies, and to investigate the risk factors associated with these two infections. Patients and methods: An analytical cross-sectional study was carried out during a free screening campaign for viral hepatitis B and C organized by the University Teaching Hospital of Yaounde from 20th to 23rd August 2019. Screening for HBsAg and anti-HCV antibodies was carried out using a rapid diagnostic test (On Site HBsAg/HCV Ab Rapid Test (CTK Inc 10110 Mesa Rim Road San Diego, CA 92121 USA) in accordance with the manufacturer’s Instruction. Positive samples had a confirmatory ELISA test. A structured questionnaire was used to investigate the risk factors for viral hepatitis B and C. Results: A total of 746 participants (412 women, 334 men) were registered. The average age of the participants was 29.6 ± 15.5 years. The prevalence of HBsAg was 10.3% (men: 14.7%; women: 7%; p = 0.002). The prevalence of HCV-Ab was 4.7% (men: 6.3%; women: 3.4%; p = 0.08). Unprotected sexual intercourse (59.4%), dental care (38.7%) and scarification (37.1%) were the main factors of HBV and HCV transmission. Male sex (OR = 2.2; IC = 1.3 ...

Oral health status of patients with decompensated liver cirrhosis in two hospitals of Yaoundé Cameroon: A comparative study

Research Article of Open Journal of Gastroenterology and Hepatology Oral health status of patients with decompensated liver cirrhosis in two hospitals of Yaoundé Cameroon: A comparative study Mathurin Pierre Kowo1,2, Alex Franklin Diffo1, Marie Elvire Nokam Abena1, Larry Tangie Ngek1, Antonin Wilson Ndjitoyap Ndam1,3, Rose-Claire Bitha1, Firmin Ankouane Andoulo1,4 1Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon; 2University Hospital Centre, Yaoundé, Cameroon; 3Yaoundé General Hospital, Yaoundé, Cameroon; 4Yaoundé Central Hospital, Yaoundé, Cameroon Background: Liver cirrhosis is an ultimate complication of all chronic liver diseases. The oral cavity especially the periodontium is affected by malnutrition, coagulation disorders, immunodeficiency which are some of the main features present in patients with liver cirrhosis. The aim of this study was to determine the prevalence and determinants of oral pathologies in patients with decompensated liver cirrhosis in two hospitals of Yaoundé Cameroon. Patients and Methods: This was a cross-sectional and analytical study comparing the oral health status of decompensated liver cirrhotic patients in Yaoundé with sex and age (±3 years) matched healthy controls from the same area. We enrolled patients with liver cirrhosis (Child Pugh score greater than or equal to 7) and their corresponding healthy controls. For each participant, socio-demographic data, clinical data on liver cirrhosis and  on oral examination were collected. Oral examination evaluated the level of oral hygiene, gingival index (GI), probing depth (PD) and Clinical attachment loss (CAL), determined and identified oral mucosal lesions. The mean Decayed-Missing-Filled-Teeth (DMFT) index and prevalence of dental caries were also determined. The groups were then compared with regards to periodontal  oral mucosal and dental variables using chi square test and Mantel – Haenszel odds ratio was used to determine the strength of association between decompensated liver cirrhosis and oral pathologies. The student‘s T-test was used to compare mean values of quantitative variables. A p-value ˂ ...

Prevalence, clinical characteristics and related mortality of cirrhosis in a tertiary hospital setting in Sub Saharan Africa

Research Article of Open Journal of Gastroenterology and Hepatology Prevalence, clinical characteristics and related mortality of cirrhosis in a tertiary hospital setting in Sub Saharan Africa Mathurin Kowo1,2, Larissa Pessidjo1, Charifa Fouwou Njoya1, Larry Tangie Ngek1, Larissa Tangan1, Christelle Nguemo1, Marthe Alogo1, Larissa Ntsama1, 2, Oudou Njoya1, Firmin Ankouane Andoulo1, 2 1Departement of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon. 2Internal Medicine unit, Yaounde University Teaching Hospital Yaoundé, Cameroon. Background: Published data on the prevalence and mortality associated to cirrhosis is rare in Cameroon. The aim of this study was to determine the prevalence, clinical and para clinical characteristics and associated mortality of cirrhosis at the Yaounde University Teaching Hospital (YUTH), Cameroon. Methods: Files of patient’s followed up or admitted for cirrhosis at the YUTH between June 1st 2016 and June 30th 2018 were reviewed. The diagnosis of cirrhosis was made based on clinical, biological, ultrasonographic and/or endoscopic signs of portal hypertension and chronic liver failure. In other to establish the cause of cirrhosis, markers of documented chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) was sought in the file of the patients and if not present, hepatitis C antibody and hepatitis B surface antigen testing were requested. In patients negative for HBV and HCV markers, alcohol intake was considered as a cause of cirrhosis in someone who have been consuming more than 30 g/day (for males) or more than 20 g/day (for females) of alcohol. Data analyses were performed using Epi info V 3.5.4. Results: During the period of study, 1748 patients were admitted in the internal medicine unit among which 117 had cirrhosis giving a prevalence of 6.7%. There were 67 males (57.3%) and 50 females (42.7%). The mean age of patients was 51 +/- 19.862 years. Patients with ...

Dr. Mohammed Naeem
Chair, Patient Safety Reporting/Consultant Pediatric Intensivist/ Head PICU (A)/ Assistant Professor, Dept. of Pediatrics. Ministry National Guard Health Affairs Riyadh, Saudi Arabia

Dr Toru Ishikawa
Gastroenterology, Saiseikai Niigata Daini Hospital

Dr. George Paraskevas
Associate Professor of Anatomy Orthopedic Surgeon, Department of AnatomyMedical School, Aristotle University of Thessaloniki, Post Box: 300, Post Code: 54124, Thessaloniki, Greece

Dr. Mahaboob Vali Shaik
Assistant Professor/Senior Scientist, Department of Genetics & stem cell Research, Narayana Medical College & Hospitals

Dr. Ifeadike Chigozie Ozoemena
Associate Professor, Department of Community Medicine, Faculty of Medicine, Nnamdi Azikiwe University

Dr. Eduardo de Moura GH
Professor, niversity of São Paulo School of Medicine, São Paulo, Brazil

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