Research Article of Research Journal of Pharmacology and Pharmacy
Anti-inflammatory Activity of Saccharum Officinarum Linn (Poaceae) Juice in Animal Models
Agbaje Esther Oluwatoyin, Ayinla Adebola Christina, **Ujomo Tejumade
Department Of Pharmacology, Therapeutics & Toxicology, College Of Medicine, University Of Lagos; **Department Of Pharmacology And Therapeutic, University Of Ibadan, Oyo State, Nigeria.
Saccharum officcinarum (SOC) juice has been used for treatment and management of several conditions including urinary tract infection, diabetes, constipation, tooth decay and bad breath according to folklore. This study was carried out to explore the anti-inflammatory effects of the juice of Saccharum officinarum in doses of 2.5, 5.0, 10.0 and 20.0 mL/kg using the following models in rats – carrageenan, histamine, serotonin, formalin-induced paw oedema, and cotton-pellet granuloma. Also employing the following models in mice – castor oil-induced diarrhea and xylene-induced ear oedema. Animals were pretreated with aspirin (100 mg/kg; p.o), cyproheptadine (10 mg/kg; p.o.), atropine (1 mg/kg p.o), dexamethasone (5 mg/kg; p.o.) and celecoxib (20 mg/kg p.o.). Oral administration of SOC juice significantly (p<0.001) reduced the right hind paw circumference induced by carrageenan, histamine, serotonin and formalin compared to control group. Furthermore, it inhibited xylene-induced ear oedema with peak effect at 20 mL/kg, as well as castor oil-induced diarrhea and cotton pellet granuloma with peak effect at 10 mL/kg. The anti-inflammatory activities of SOC were significant (p<0.05) when compared with aspirin, cyproheptadine and dexamethasone. The study revealed the potent anti-inflammatory activities of the juice of S. officinarum.
Keywords: Saccharum officinarum, anti-inflammatory, carrageenan, aspirin, histamine, rat
How to cite this article:
Agbaje Esther Oluwatoyin, Ayinla Adebola Christina, Ujomo Tejumade. Anti-inflammatory Activity of Saccharum Officinarum Linn (Poaceae) Juice in Animal Models.Research Journal of Pharmacology and Pharmacy, 2019, 3:7. DOI: 10.28933/rjpp-2019-09-2205
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