PUNICA GRANATUM Vrs COVID – 19 Fruit to Drug


PUNICA GRANATUM Vrs COVID – 19 Fruit to Drug


Deepak Bhattacharya1*, Dr. P K Mohanta. MD (Ay)2, Dr. Debasish Mishra3, Dr. K C Sethy4, Dr. Jyotsana Sharma5, Dr. P K Pradhan6, Dr. Vahideh Samadiyan7, Dr. Mahtab Pouyanfar8, Dr. Parisa Mohamadpour9, Prof. Ghassem Habibi Bibalani10

1Research & Nursing, At Fight-Cancer at Home, Sri Radha Krishna Raas Mandir, Kedar Gouri Road, Bhubaneswar–751002,Odisa, India. 2MD (Ay), Govt Drug Inspector; Registrar Ay Council; Principal. IGMMC & Hospital, H-2/58,SS Enclave, Khandagiri,Bhubaneswar-751030, Odisa. 3MBBS, Director, Model Blood Bank, Capital Hospital (Govt., Apex) – Bhubaneswar, Odisa, India. 4LLM, Ph.D, Advocate, District & Sessions Court, Bhubaneswar, Odisa, India. 5Ph.D; Director (Act) & Principal Scientist (Plant Pathology) ICAR-National Research Centre  on  Pomegranate, Solapur, Maharastra, India, 413255. 6BAMS, Medical Officer, Indian Red Cross Society Clinic (Ay), Koraput, Odisa, India. 7Ph.D, Lecturer, University of Applied Science and Technology, Shahid Sardari Branch, Tabriz, East Azerbaijan. 8Ph.D, Instructor, TVTO-Medicinal Plants, Teheran, Iran. 9Ph.D, Asst Prof. Forest & Rangeland Research & Watershed Management Dept; Gilan Agril & Natural Resources Research & Edu center; Rasht, Iran. 10Department of Natural Resources, Shabestar Branch, Islamic Azad University, Shabestar, Iran


Punica granatum is historically known worldwide as a versatile medicinal fruit. 2 major varieties are presented (i) indo Ayurvedic type (Punica Ayurvedica ?) that is small, harsh and yields no juice and (ii) the juice variety which is commercialised. Indo-Iranian joint effort presents a tome of textual data pertaining to the medicinal aspects of Punica. Gallagic group. Enantiomers. Antagoniostic. Ayurvedic texts and Occidental research modelled papers in tabulated form chronologically succinctly bringing out the evidence based historiography & medico-cultural heritage. On such platform a range of formulations; fruit-to-finished product are presented for the 1st time machine makeable and very specifically also by hand, at home. Poly pathology spectrum; versatile therapeutic range; medico-legal; lyophilisation; sterilisation; etc. aspects are also indicated. Includes Tablets; Suspensions for General to Geriatric case types. Ground breaking. Frank.


Keywords: Punica Granatum Formulation For Covid; Ellagic acid is Anti-virus; Ellaghitanins; Gallagic group

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How to cite this article:
Deepak Bhattacharya, P K Mohanta,Debasish Mishra,K C Sethy, Jyotsana Sharma, P K Pradhan, Vahideh Samadiyan, Mahtab Pouyanfar, Parisa Mohamadpour, Ghassem Habibi Bibalani. PUNICA GRANATUM Vrs COVID-19 Fruit to Drug. Research Journal of Pharmacology and Pharmacy, 2020; 4:9. DOI: 10.28933/rjpp-2020-08-0305


REFERENCES

1. Why a pomegranate? British Medical Journal 2000; 321 doi: https://doi.org/10.1136/bmj.321.7269.1153
2. Personal Communication of Dr. J Sharma, Di-rector, NRCP-ICAR.
3. http://nrcpomegranate.icar.gov.in/
4. https://www.iihr.res.in/
5. Bhattacharya, et.al, 11-5-2020. COVID–2019: In-dian Medicine Sources Drug Discovery Possibili-ties, Scholarly Community Encyclopedia, MDPI, https://encyclopedia.pub/1268
6. 6 – Bhattacharya Deepak, 2014. Select palm leaf manuscripts of Health Care Sciences, Indian Journal of History of Science, Indian National Science Academy, Vol. 49.3, pp. 294-97.
7. Director, https://nrcpomegranate.icar.gov.in/Contact .
8. Jorfi, Abdul Amir, 1994. ‘Iran and India: Age old Friendship’ by, India Quarterly – A Jor of Interna-tional Affairs, Vol. 50 Issue 4, pp. 65-92. https://doi.org/10.1177/097492849405000404
9. Vajpayee, Atal Bihari, 2001. India Greatly Values Its Relationship With Iran, Teheran Times, 10-4-2001, pp-Politics.https://www.tehrantimes.com/news/61466/India-Greatly-Values-Its-Relationship-With-Iran-Vajpayee & (preceded by J L Nehru Memorial Museum Library) https://www.nationalheraldindia.com/internation-al/iran-draws-inspiration-from-jawaharlal-neh-ru-as-us-sanctions-loom-over-ties-with-india (Both – PM of India).
10. Bhattacharya, Deepak & Unnati Bhattacharya, 2018. Anti Tumor Orient Experiment – ATOX, In-dian Journal of Natural Sciences, Vol.8 / Issue 48, pp. 13996 -14002.
12. Behera Jagdish & Deepak Bhattacharya, 4/2020. AVIR – Anti Virus India Research COVID-19: Drug Discovery Safe Sources, Indian Jor Of Natural Sciences, Vol.10 / Issue 59 / pp.18923 – 18929.
11. https://www.academia.edu/ 31709894/M_R_C.pdf AND https://www.researchgate.net/ publication/ 314229235_METASTASIS_REVERSAL_CENTRE
13. Behera Jagdish & Deepak Bhattacharya, 4/2020. Covid-19 Glossary, NIH-Figshare,https://figshare.com/articles/COVID_GLOSSARY/12091854
14. Peatey, C. L., D. Leroy, D. L. Gardiner and K. R Tren-holme, 2012. “Anti-Malarial Drugs: How Ef-fective Are They Against Plasmodium falciparum Gametocytes?” Malaria Journal, Vol. 11, p. 34. doi:10.1186/1475-2875-11-34
15. Soh P N, et al. 2009. In Vitro And In Vivo Proper-ties Of Ellagic Acid In Malaria Treatment, Antimi-crob Agents Chemotherapy. 2009;53(3):1100 -1106.doi:10.1128/AAC.01175-08.
16. Dell’ Agli M, et.al., 2010. Ellagitannins of the fruit rind of pomegranate (Punica granatum) antago-nize in vitro the host inflammatory response mechanisms involved in the onset of malaria. Malaria Journal, 2010;9:208. doi:10.1186/1475-2875-9-208.
17. Lekana-Douki, Deepak Bhattacharya, et.al., In-ternational Journal of Clinical Medicine, 2012; 3(1):1-8. Doi:10.4236/ijcm. 2012.31001.
18. Prato M, Giribaldi G. Matrix Metalloproteinase-9 and Hemozoin: Wedding Rings for Human Host and Pf Parasite in Complicated Malaria. Journal of Tropical Medicine. 2011;1-11. (special ref., p.6). doi:10.1155/2011/628438.
19. Bhattacharya Deepak (2012) Relevance Of Eco-nomic Field Microscope In Remote Rural Regions For Concurrent Observation Of Malaria & In-flammation, Advances In Infectious Diseases, Vol. 2, pp.13-18. doi:10.4236/aid.2012.21003.
20. Deepak Bhattacharya, “Fight Malaria at Home: Therapeutic & Prophylaxis Clinical Data,” Asian Pacific Journal of Tropical Disease, Vol. 1, No. 2, 2011, pp. 142-149.
21. Deepak Bhattacharya, 2017. Fight Malaria at Home: Ghare Maro Malaria Social Service to Drug Discovery – Bottom Up Model: A Review, Air Water Borne Diseases, 2017, Vol.6:1 DOI: 10.4172/2167-7719.1000135
22. 22 – Bhattacharya D. Punica granatum’s dermis indicates prophylaxis against malaria & wide spectrum anti-viral property in human use. Amer-ican Journal of Tropical Medicine & Hygiene, Oct. 2004. Abstract No. 968, 171(4), 288. http://www.ajtmh.org/content/71/4_suppl/225.full.pdf+html.
23. https://figshare.com/account/home { Login: oddisilab1@dataone.in & Password : Kedar-Gouri123* ).
24. Sharma J. Ashis Maity, 2010. Fruit Vegitable & Cereal Sciences and Biotechnology, 4 (spl issue 2), pp.56-76.
25. Patil, P.G., Jamma, S.M., Singh, N.V. et al. 2020. Assessment of genetic diversity and population structure in pomegranate (Punica granatum L.) using hypervariable SSR markers. Physiol Mol Biol Plants. https://doi.org/10.1007/s12298-020-00825-y
26. Seeram NP, et.al., 2008. Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. Jor of Medicinal Food 2008, 11:390-394. ALSO SEE same 1st author, Jor of Nutr 2006,136: 2481-2485 AND again Clin Chim Acta 2004, 348:63-68.
27. Reddy, M.K., et.al., 2007. Antioxidant, antimalarial and antimicrobial activities of tannin-rich frac-tions, ellagitannins and phenolic acids from Punica granatum L. Planta Medica, 73, 461–467.
28. Dell’ Agli M, et.al., 2009. Antiplasmodial activity of Punica granatum L. fruit rind, Journal of Eth-nopharmacology, Vol. No. 125 pp. 279–285. doi:10.1016/j.jep.2009.06.025
29. Opcit. Ref No 17.
30. Bhattacharya, Deepak, 2017. Nano Tech Tablet: A Concept. Novel Approaches in Drug Designing & Development, Vol. 2(2): 555582.
31. http://www.fao.org/3/a-au112e.pdf
32. Opcit. Ref No 19.
33. Longtin, R 2003 The Pomegranate: Nature’s Power Fruit ? Journal of National Cancer Institute Vol.95:346–8.
34. Paul E. Bock, K. R. Srinivasan, and Joseph D. Shore, 1981. Activation Of Intrinsic Blood Coag-ulation By Ellagic Acid: Insoluble Ellagic Ac-id-Metal Ion Complexes Are The Activating Spe-cies, Biochemistry, Vol.20 (25), 7258-7266. DOI: 10.1021/bi00528a032
35. (i)https://www.academia.edu/31560111/Effect_of_Plant_ Extract_R_Sol_on_Blood(ii)https://www.researchgate.net / publication/313839561_R_-_Sol_Magic_Effect_on_Blood
36. Collectorate of Korpaut, Official Letter dycolemkpt@nic.in (dt. 21-5-2020), Official Site: koraput.nic.in/new/right/section.htm
37. Bhattacharya, Deepak, 2017. Nursing Defeats Cancer ?, J Complement Med Alt Healthcare, Vol. 5 Issue 3 – November 2017. DOI:10.19080/ JOJNHC.2017.05.555662
38. Ameh SJ, et.al., 2011. Medical Herbalism And Herbal Clinical Research: A Global Perspective. British Journal of Pharmaceutical Research. 1.4:99-123.
39. https://www.nhp.gov.in/NHPfiles/185-C_2019_LS_Eng.pdf
40. The Samaja, Odia Daily, Koraput, Ed 27-3-2020, page-7. https://samajaepaper.in/indexnext.php?pagedate=2020-3-27&edcode=79&subcode=79&mod=1&pgnum=1&type=a
41. The Samaja, Odia Daily, Koraput, Ed 17-5-2020, page -7. https://samajaepaper.in/in dexnext.php?pagedate=2020-5-17&edcode=79&subcode=79&mod=1&pgnum=1&type=a
42. Bhattacharya Deepak, et.al., 2013 Transmission Blocking of Year Round Resistant Malaria in Koraput (India) by OMARIA – A New Antimalarial Phytotherapy, British Journal of Pharmaceutical Research, Vol. 3, No. 1, pp. 54-77, 2013
43. Badam Lalita, Annual Report 2002-03, National Institute of Virology, Pune, India, Screening of AVIR, Other Viruses, No.6-a, p.126.
44. Indian Express, J Roy-Chowdhury, 01-10-2019. “….Gandhiji thought instead of concentrating on mass production, we need to concentrate on production by the masses, where jobs are created so that demand too could be created…” Dr. Satya Narayan Sahu, Gandhian thinker.
45. Gandhi M K. An Autobiography (The story of my experiments with truth). 1st Ed. Navjivan Trust, Ahmedabad; 1927. www.myweb.tiscali.co.uk/kenanderson/histemp/whitemansgrave.html.
46. https://encyclopedia.pub/1490