Antiparasitary Activity Of The Juglone Compound: A Narrative Review

Antiparasitary Activity Of The Juglone Compound: A Narrative Review

Paulo Henrique Valença Nunes1,2*, José Rafael da Silva Araújo2, Victor Hugo Barbosa dos Santos1,2, Renan Andrade Fernandes de Souza1,2, André de Lima Aires1,2, Mônica Camelo Pessoa de Azevedo Albuquerque1,2

1Laboratorio de Imunopatologia Keizo Asami; 2Universidade Federal de Pernambuco;

Objective: To report, based on the literature, the action of the compound 5-hydroxy-1,4-naphthoquinone against parasites (protozoa and helminths) that affect humans.

Methods: This is a narrative review that used Pubmed and Google Scholar as a data tool. This work included articles published until September 2020 that were directly related to the use of the compound juglone in antiparasitic trials.

Results: The compound juglone demonstrated promising effects as a human and animal antiparasitic substance. In protozoa, the Apicomplexo Toxoplasma gondii parasite showed a high mortality rate in concentrations of juglone in the nanomolar range. The juglone showed an average inhibitory concentration (IC50) of 1.62 µM, >100 µM, and 2.02 µM µM for Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani, respectively. Also, the juglone showed antihelmintic activity on Hymenolepis nana in mice, and on adult worms of Schistosoma mansoni (LE strain) with IC50 34.16 µM, 32.14 µM, and 25 µM in the 24h, 48h, and 72 h, respectively.

Conclusion: The results published so far show the in vitro antiparasitic potential of juglone, and the need for further studies on the specific mode of action that interacts with parasites. Besides, the literature is still limited to studies that evaluate in vivo the compound juglone, requiring better information on its interaction with living organisms.

Keywords: natural compounds, antirapasite, pharmacology activity

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Paulo Henrique Valença Nunes, José Rafael da Silva Araújo, Victor Hugo Barbosa dos Santos, Renan Andrade Fernandes de Souza, André de Lima Aires, Mônica Camelo Pessoa de Azevedo Albuquerque.Antiparasitary Activity Of The Juglone Compound: A Narrative Review. Research Journal of Pharmacology and Pharmacy, 2021, 5:13. DOI: 10.28933/rjpp-2021-06-1805


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