Osteosarcoma’s STAT-3 Vrs Kaempferia parviflora’s Compounds : Possible Drug Candidates

Osteosarcoma’s STAT-3 Vrs Kaempferia parviflora’s Compounds : Possible Drug Candidates

Chandra Sekhar Tripathy¹, Anil Kumar², Santosh Kumar Panda³, Santosh Kumar Behera⁴, Gaurav Giri⁵, Asadollah Asadi⁶, Santanu Kumar Budhia⁷, Arash Abdolmaleki⁸, Easter Khura⁹, P K Mohanta¹⁰, Muhammad Akram¹¹, Deepak Bhattacharya¹²*

¹M.Sc., Regional Medical Research Centre, Bhubaneswar, Odisha, India; ²Principal Scientist & Head, Division of Design of Experiments I.C.A.R-I.A.S.R.I., Library Avenue, New Delhi, India, PIN- 110012; ³ MS, ENT Surgeon, Capital Hospital; Govt., Bhubaneswar, Odisa, India; ⁴Ph.D., Scientist Grade II, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat,India; ⁵BAMS,  Govt Drug Inspector, AYUSH, Govt of Odisha, Bhubaneswar, India; ⁶Associate Professor, Department of Biology, University of Mohaghegh Ardabili,  Iran; ⁷BA; Traditional Ayurvedacharya, Nagharen Temple Rd, Baabajee Padaa, Balangir, Odisha,India PIN – 767025; ⁸Assistant Professor, Animal Physiology, University of Mohaghegh Ardabili, Faculty of Advanced Technologies. Department of Biology; ⁹M Sc (nursing), Vice Principal, School of Nursing, Raxaul, Bihar, India – 845305; ¹⁰MD (Ay), Govt Drug Inspector; Registrar Ay Council; Principal. IGMMC & Hospital, H-2/58,SS Enclave,Khandagiri,Bhubaneswar-751030, Odisha; ¹¹BEMS, M.Phil, Ph.D, Chairperson, Dept. of Eastern Medicine, Government Collage University, Faisalabad, Pakistan; ¹²Ph.D., Policy, Nursing, At Fight-Cancer at Home, Medicinal Toxicology & QC, At : Sri Radha Krishna Raas Mandir, KedarGouri Road, Bhubaneswar–751002, Odisa, India.

Osteosarcoma is a dominant type of bone cancer, associated with osteophytes (bone cells). Afflicts all age groups; generally manifesting in long bones of human physiology(also other parts; including fine joints). Chemotherapy, surgery and radiation are the current therapeutics – with uncertain results; often associated with high degree of failure; swift relapse; rebound aggression and above all with debilitating post treatment out come conditions. In this investigation in silico drug designing procedures have been used to predict natural compounds from Kaempferia parviflora (black ginger) as possible drug candidates for osteosarcoma. 8 of its phyto-compounds (PCs) are found to be non-toxic and also pass the Lipinski’s rule of 5 (@ 100%) vis-à-vis  the over expressed Signal Transducer And Activator Of Transcription 3(STAT3) protein of the dreaded osteosarcoma.  All the 8 PCs indicate better binding affinity (greater likeness) than the current best popular allopathic drug Zoledronic acid (Toxic). All the 8 offer good-excellent likeness. Alpha- Copaene (non Toxic) emerges as the Champion.

Keywords: Phytochemicals, STAT3, bone cancer, Sarcoma, In silico, molecular docking.

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How to cite this article:
Chandra Sekhar Tripathy, Anil Kumar, Santosh Kumar Panda, Santosh Kumar Behera, Gaurav Giri, Asadollah Asadi, Santanu Kumar Budhia, Arash Abdolmaleki, Easter Khura, P K Mohanta, Muhammad Akram, Deepak Bhattacharya.Osteosarcoma’s STAT-3 Vrs Kaempferia parviflora’s Compounds :Possible Drug Candidates.Research Journal of Pharmacology and Pharmacy, 2022, 6:15. DOI: 10.28933/rjpp-2022-01-1805

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