Research Article of Scientific Research and Reviews
RISK FACTORS FOR MULTI DRUG-RESISTANT TUBERCULOSIS AMONG TUBERCULOSIS PATIENTS OF NEKEMTE REFERRAL HOSPITAL, OROMIA REGIONAL STATE, WESTERN ETHIOPIA, 2017
ZalalemKaba Babure1*,KassahunTegegne Bidu2, FekaduAssefa Jiru3, TesfayeDagne Weldemarium4,and AkliluFikadu Tufa5.
1Quality officer at East Wollega Zonal Health Office, Nekemte, Oromia, Western Ethiopia,
2Program Officer at USAID/JSI Transform: Primary HealthCare Project, East Wollega Zone, Nekemte, Western Ethiopia
3High Quality Clinical Care Technical Advisor Oromia Regional Health Bureau, Addis Ababa, Ethiopia
4Department of health economics, management and policy, College of Health Sciences, Jimma University
5Program Officer at USAID/JSI Transform: Primary HealthCare Project, East Wollega Zone, Nekemte, Western Ethiopia
Multidrug-Resistance Tuberculosis (MDR-TB) is tuberculosis (TB) that is resistant to two first-line drugs; both isoniazid and rifampicin. Globally in 2015, there were an estimated 480, 000 new cases of multidrug-resistant TB. According to the anti-tuberculosis drug resistance survey conducted nationwide in Ethiopia in 2012 among 804 newly diagnosed TB cases 1.6 % were found to be infected with MDR-TB. The continuous challenge in the occurrence and management of Multidrug-Resistant Tuberculosis (MDR-TB) in the country in general and Nekemte Referral hospital in particular prompted this study which seeks-to investigate the risk factors for MDR-TB.Unmatched case control study design was conducted to identify the risk factors for multi-drug resistant tuberculosis among tuberculosis patients of Nekemte Referral Hospital. All MDR-TB (21 cases) and Non-MDR-TB (44 controls) patients’ registered from September 2016to August 2017 in this Hospital were included in the study. Face-to-face interview and Patient medical records review were used to collect the data. In bivariate analysis; variables which had P-value <=0.25 wereentered into multi-variate logistic regression model. P-value <0.05 taken as statistically significant. A total of 65 tuberculosis patients (21 cases and 44 controls) included in this study; response rate 100 %. Previous tuberculosis treatment (AOR = 0.975, 95 % CI = 0.957 – 0.994), history of defaulter (AOR=0.055, 95 % CI=0.008-0.391), history of Smoking (AOR=74.833, 95 % CI=1.563-36.248), number of rooms in the house (AOR=5.410,95 % CI=1.579-18.536) and presence of HIV/infection (AOR=0.232,95 % CI=0.065-0.823) were statistically significant predictors of having multidrug-resistance tuberculosis.History of- previous tuberculosis treatment; defaulter and smoking, number of rooms in the house, and presence of human immune virus infection were significant predictors in this study.Health education on adherence to anti-tuberculosis drugs and risky behaviorshould be given a special attention.
Keywords: Multidrug-resistant, Tuberculosis, Nekemte, Risk factor, Case-control.
How to cite this article:
ZalalemKaba Babure,KassahunTegegne Bidu, FekaduAssefa Jiru, TesfayeDagne Weldemarium,and AkliluFikadu Tufa.RISK FACTORS FOR MULTI DRUG-RESISTANT TUBERCULOSIS AMONG TUBERCULOSIS PATIENTS OF NEKEMTE REFERRAL HOSPITAL, OROMIA REGIONAL STATE, WESTERN ETHIOPIA, 2017. .Scientific Research and Reviews, 2019, 12:102
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