American Journal of Dermatological Research and Reviews

Review Article of American Journal of Dermatological Research and Reviews The Effectiveness of Ozone Therapy on Diabetic Ulcer Repair: A Systematic Review and Meta-analysis: Study of Changes in Wound Size Marissa Gondo Suwito1*, Retno Indar1, Puguh Riyanto1, Asih Budiastuti1, Diah Adriani Malik1, Muslimin1, and Suhartono2 1Dermatology, Venereology, and Aesthetic Department, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center, Dr. Sutomo Street No. 16, 50244, Semarang, Indonesia. 2Environmental Health Department, Faculty of Public Health, Diponegoro University, Prof. Soedarto Street, Tembalang, 50275, Semarang, Indonesia. Introduction: Diabetic foot ulcer (DFU) is a typical dermatological complication often found in patients with diabetes mellitus (DM). Chronic hyperglycemia state causes microvascular impairment that leads to loss of peripheral sensory, motor, and autonomous functions. The current diabetic ulcer therapy has not yet provided a satisfactory reduction of the ulcer area; thus, several adjuvant therapies were tried, such as using ozone therapy, either systematically or topically. Ozone increases the cell membrane permeability to glucose, increases oxygen metabolism, improves oxidative preconditioning, stimulates endogenous antioxidant systems, and has anti-inflammatory and antibacterial effects. Methods: This study was an analytic observational study, with systematic review and meta-analysis. Data searching were conducted online at Pubmed-MEDLINE, Scopus, EBSCOhost, ProQuest, Cochrane library, ClinicalTrials.gov, and Google Scholar, as well as hand-searching from libraries in Indonesia. Five most relevant articles included in the qualitative (systematic review) (n = 449) and three of those five articles included in the quantitative analysis (meta-analysis) (n = 211). Reduction of ulcer area was assessed. Results: The meta-analysis of effectiveness of ozone intervention group compared to the control group showed a homogeneity in data (Q=95.547, df=2; p=0.000, Tau2=5.276). Meta-analysis showed the value of Q statistic was z value = -9.478; (p=0.000). This shows that the overall administration of ozone can significantly improve the diabetic ulcer repair. The overall standardized ...

Review Article of American Journal of Dermatological Research and Reviews The Effectiveness of Oral Fish Collagen Supplementation on Skin Aging: A Systematic Review and Meta-analysis of Skin Hydration, Skin Elasticity, and Skin Wrinkles Imelda Gunawan1*, Retno Indar Widayati1, Puguh Riyanto1, Asih Budiastuti1, Diah Adriani Malik1, Muslimin1, Widyawati1, and Suhartono2 1Department of Dermatology, Venereology, and Aesthetic, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital Medical Center, Dr. Sutomo Street No. 16, 50244, Semarang, Indonesia.2Department of Environmental Health, Faculty of Public Health, Diponegoro University, Prof. Soedarto Street, Tembalang, 50275, Semarang, Indonesia. Introduction: Skin aging is a complex biological process with cumulative structural and physiological changes, progressive changes in each layer of the skin, and changes in the appearance of the skin. Human skin undergoes 2 types of skin aging, that are intrinsic and extrinsic skin aging. Skin aging is characterized by a decrease in skin hydration and elasticity, as well as an increase in skin wrinkles. Anti-aging strategies are still being developed. A new anti-aging therapy modality that has been widely used is nutraceutical supplementation, such as fish collagen. Fish collagen is a new alternative source of collagen with a high degree of homology to human collagen structure and high bioavailability. The aim of this study was to assess the efficacy of oral fish collagen supplementation on skin aging. Methods: This study was an analytic observational study, with systematic review and meta-analysis. Data searching was conducted online at Pubmed-MEDLINE, EBSCO (CINAHL), Scopus, SpringerLink, ProQuest, Cochrane Library, ClinicalTrials.gov, Cambridge Core, and Google Scholar, as well as hand searching from libraries in Indonesia. Twelve studies were included in the qualitative analysis (systematic review) (n=753 subjects) and 6 of them were included in the quantitative analysis (meta-analysis) (n=426 subjects). Results: The results of the meta-analysis showed that the increase in skin hydration in the group ...

Research Article of American Journal of Dermatological Research and Reviews Micro-nevi in peri-tumoral skin of cutaneous melanoma and basal cell carcinoma Denise Malki1, MD. Martin Andersson1, MD. Britta Krynitz1,2, MD, PhD. Bernt Lindelöf3,MD, PhD. 1Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden; 2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; 3Department of Medicine, Dermatology and Venerology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. Background: Harboring many melanocytic nevi is a risk factor for melanoma. The prevalence of micro-nevi, melanocytic nevi that can only be detected microscopically, has been studied scarcely and the significance is unknown. Objectives: To systematically analyze the presence of micro-nevi in cutaneous excisions from cutaneous melanoma and basal cell carcinoma to achieve an insight in the density of micro-nevi per mm peri-tumoral skin. Also to speculate in the relevance and significance of micro-nevi for evolving melanoma at the same anatomical site. Methods: We re-examined histologically peri-tumoral skin of primary and re-excised melanomas and primary excisions of basal cell carcinomas for comparison. The size of a micro-nevus was defined to a diameter < 2 mm, of either a junctional, compound or intradermal nevus. Results: 104 melanoma and 208 basal cell carcinoma cases were microscopically re-examined. In the melanoma group 6 micro-nevi were found. The sum of the peri-tumoral skin was 1768 mm, giving a density of 1 nevus per 295 mm. In the basal cell carcinoma group 5 micro-nevi were found. The sum of the peri-tumoral skin was 1370 mm, giving a density of 1 nevus per 274 mm. No difference in the density of micro-nevi in the two groups of skin cancer was found. Conclusions: The significance of these micro-nevi remains unclear. The aim with this study is to draw attention to the existence of micro-nevi and further studies are needed to determine the ...

Review Article of American Journal of Dermatological Research and Reviews Adverse Drug Reactions Awareness Among Sample of People in Northern Region, Saudi Arabia Fawwaz Freih Alshammarie [1] , Yasmeen Ali Muraizeq [2] , Rahaf Turki Aldhaban [2] , Asma Mohammed Almutairi [2] , Monerah Thaar Alshammari [2] [1]Assistant Professor, Department of Dermatology, College of Medicine, University of Hail, Hail, Saudi Arabia. [2]-Medical student, College of Medicine, University of Hail, Hail, Saudi Arabia. Background: Drug reactions are a fundamental issue in many branches of medicine. Adverse drug reactions result in high mortality and morbidity globally. There is always the risk of unwanted side effects associated with the use of any substance that has a therapeutic effect. The safe use of drugs remains a critical issue for all health care professionals. Objective: The current study investigates the level of drug reaction awareness among the public in northern Saudi Arabia. Materials/methods: This was a questionnaire-based cross-sectional study. Data were collected using Google Forms, which were coded and processed using Microsoft Excel and SPSS version 23. Results: Altogether 475 people participated in this study including 382 women [80.4%] and 93 men [19.6%]. Of the 475 participants, 83.6% were aware of drug reactions, 40.4% believed drug reactions are hereditary, 50.9% had received a previous skin allergy test, and 21.3% had received a previous blood test for an allergy.   Conclusion: The public in northern Saudi Arabia are aware of drug reactions. We found that only half of the participants in our study had received a skin allergy test. It is the responsibility of physicians to provide the community with a valuable database of information on the adverse effects of drugs. We recommend that health care  institutions carry out more studies with a larger sample to improve the understanding and awareness of drug reactions. Keywords: Adverse ...