American Journal of Dermatological Research and Reviews


Research Article of American Journal of Dermatological Research and Reviews Infantile acne is a medical problem that calls for therapy 1Khalifa E Sharquie, MD,PhD,FRCP Edin; 2Hamed A Al Farhan, MD,DD; 3Wisam S Najim, MD,FICM; 4Raed I Jabbar, MD ,CABD. 1Department of Dermatology, College of Medicine, University of Baghdad, Medical City Teaching Hospital,Baghdad ,Iraq. 2,3Deprtment of Dermatology, College of Medicine ,Tikrit University, Iraq. 4Department of Dermatology ,Fallujah Teaching Hospital ,Al-Anbar Health Directorate , Anbar , Iraq. Background: Acne vulgaris of infants is a well-recognized medical and cosmetic problem as it may cause severe scarring of the face. Hence medical treatment is essentially needed. Objective: To record all patients with infantile acne vulgaris and to do full demographic and clinical evaluation. Patients and methods:This is case series clinical descriptive study with interventional  therapeutic trial that included all patients with infantile acne vulgaris that were seen during the period from Jan 2021 – September 2021 years. All demographic and clinical features were recorded. The clinical  scoring of acne severity was done as follow:mild when the rash was mainly comedones,moderate mainly papules and pustules and severe mainly nodules and scarring. Any triggering factors were recorded including hormonal changes. Therapy was started by giving topical 2% clindamycin twice a day and oral trimethoprim-sulfamethoxazole suspension one teaspoonful twice a day for 1-2 months. Results: This study included 28 patients with infantile acne, with 19(67.86%) males and 9(32.14%) females with male to female ratio;2.1. The age of patients ranged from 1-24 months, with a mean 14.6 ±6.1.The duration of rash was ranged from 4-8 weeks. The commonest sites affected were cheeks in 27(96.4%) cases, followed by forehead in 8 (28.6%), then chin in 6 (23.1%), and nose 6 (23.1%) of the cases. Scoring of severity of acne showed moderate in 13(46.4%), followed by mild in 9 (32.1%), ...


Review Article of American Journal of Dermatological Research and Reviews The Effectiveness of Microneedling Therapy on The Severity of Acne Scars According to Goodman and Baron: A Systematic review and meta-analysis Oktavianus Nugroho*, Diah Adriani Malik, Retno Indar Widayati, Suhartono, Asih Budiastuti, Puguh Riyanto, Muslimin Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University / Dr. Kariadi Hospital, Dr. Sutomo street No. 16 Semarang-Indonesia. Background: The emergence of acne scars due to skin damage in the acne healing process and causes psychological effects. The management of acne scars can be done in several methods. Microneedling is a very simple, safe, effective, and minimally invasive therapeutic technique compared to other therapeutic modalities in acne scars. The resulting wound is micro-sized, and promotes the growth of growth factors and collagen production. We aimed to assess the effectiveness of using microneedling as an acne scar treatment option. A systematic review and meta-analysis were qualitatively and quantitatively conducted from RCTs, assessing the effectiveness of microneedling in reducing the severity of acne scars according to Goodman and Baron in the treatment of acne scars. Methods: Medline Pubmed, PMC, Scopus, Google Scholar, and JDC library, eligible search. Ten studies (n=514) were analyzed qualitatively with 2 studies (n=53 subjects) and quantitatively analyzed by 2 studies (n=90 subjects). Both analyzes were included in the meta-analysis. The mean age of the participants was 40.5 years. The application of microneedling intervention as monotherapy or a combination in patients with acne scarring was followed for at least 16 weeks, the results obtained were the mean reduction in the degree of acne scarring after microneedling. Result: The combination of microneedling treatment obtained a qualitative decrease in the degree of acne scars according to Goodman and Baron with a Z value (-4.299) and P=<0.001 lower than the control (PRP) with a significant difference. The ...


Review Article of American Journal of Dermatological Research and Reviews Topical treatments to reduce severity of radiation dermatitis in breast cancer patients-a systematic review Tania Nakra; Bunmi Ibrahim School of Allied Health Sciences. De Montfort University, Leicester. United Kingdom. Breast cancer (BC) patients are likely to undergo radiotherapy (RT) treatment which may lead to the development of the skin toxicity, radiodermatitis (RD). The purpose of this systematic review is to evaluate the effectiveness of topical interventions in reducing the severity of RD in females BC patients. Appropriate clinical studies were independently identified through a bibliographic search in PubMed and Nine randomised, controlled clinical trials (RCTs) which stated a clear inclusion and exclusion criteria, were included in this review. The studies included in this review were conducted in the last 10 years and researched the effectiveness of only topical therapies on female BC patients. The severity of RD starting at baseline 0 to endpoint was measured using the Radiation Therapy Oncology Group (RTOG) scale, and results show most patients experienced a RTOG score change of 0-1 or 0-2. A significant relationship between results obtained from 0-1 and 0-2 was shown (p < 0.00001). Results suggest Radioskin 1&2 cream is the most effective topical treatment for RD as 95% of patients experienced a RTOG score change of 0-1 compared to 5% experiencing 0-2. However, controlled treatments like general care and Aqua Cream seem to be the least effective, as 1.9% of patients administrating general care experienced a RTOG score change of 0-1 compared to 41.9% experiencing 0-2. Keywords: Breast cancer; Radiotherapy; Radiodermatitis; Topical Treatments ...


Research Article of American Journal of Dermatological Research and Reviews Stability of chemical UV filters in sunscreens exposed to vehicle cabin temperatures Leslie K. Dennis 1, 2, *, Alesia M. Jung1, Kelly A. Reynolds2,3, Chiu-Hsieh Hsu1, Leif Abrell 4,5 1Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.2University of Arizona’s Environmental Exposure Science and Risk Assessment Center (ESRAC), Tucson, AZ, USA.3 Department of Community, Environment & Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.  4Department of Chemistry and Biochemistry, College of Science, University of Arizona, Tucson, AZ, USA.5Department of Environmental Science, College of Agricultural and Life Sciences, University of Arizona, Tucson, AZ, USA. Background: Sunscreen companies recommend replacing your chemical sunscreen every year.  Consumer inquiries about product integrity under excessive exposure to heat prompted the FDA to add a requirement statement to sunscreen products indicating a need to protect stored sunscreen from excessive heat and direct sun. If heat exposure indeed affects chemical sunscreen stability, then in some areas, replacement may be warranted earlier than a year. Methods: We examined real-life scenarios related to the storage of sunscreen containers inside vehicles sitting in natural sunlight to provide information about the stability of sunscreen active ingredients under real-life storage conditions.  The active ingredients avobenzone, oxybenzone, homosalate, octinoxate, octisalate, and octocrylene in samples of sunscreens were examined after heat exposure over six months using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.  The calculated levels of each active ingredient were then compared between the non-heat exposed samples and the heat exposed samples using a paired t-test to look for decreases in active chemicals from heat exposure. Results: No important differences were seen for heat exposure in this study of 378 hours of temperatures above 37.8 °C, with ...

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American Journal of Dermatological Research and Reviews