American Journal of Dermatological Research and Reviews


Research Article of American Journal of Dermatological Research and Reviews Necrotizing fasciitis at the extremities and its management Hatim ABID1*, Mohammed EL IDRISSI1, Abdelhalim EL IBRAHIMI1, Abdelmajid ELMRINI1, Nissrine AMRAOUI2, Sara ELLOUDI2, Hanane BAYBAY2, Fatima Zahra Mernissi2 1Department of osteoarticular surgery B4, HASSAN II teaching hospital, Fes, Morocco. 2Department of dermatology HASSAN II teaching hospital, Fes, Morocco. We report in the light of a literature review the results of 28 patients treated for Necrotizing Fasciitis (NF) at the extremities between 2012 and 2017 with a view to a prospective study with longer following up and a greater number of patients. Keywords: Necrotizing Fasciitis; extremities; treatment ...


Research Article of American Journal of Dermatological Research and Reviews Comparison of the efficacy of Subcision with Fractional Carbon Dioxide Laser versus Subcision with Microneedling Fractional Radiofrequency in the Treatment of Atrophic Post acne Scars Nabeel K. Al-Hamzawi Department of Dermatology, Al-Diwaniyah Teaching Hospital, Diwaniyah, Iraq Background: Many interventions have been used to treat post-acne scars, with various degrees of efficacy and adverse reactions. Multimodal approach can achieve better results for improving the physical appearance that even if minor may result in significant distress and reduced quality of life. Objective: To compare the efficacy of subcision with fractional carbon dioxide (CO2) laser and subcision with microneedling fractional radiofrequency (RF) in treating post-acne scars and to study their adverse effects. Methods: In this prospective, interventional clinical study, a total of 64 patients with post-acne scars were enrolled. The patients were randomly allocated into two groups of 32 patients each, in which group A was treated with subcision plus fractional carbon dioxide laser (CO2) and group B was treated with subcision plus microneedling fractional radiofrequency (RF) every 6 weeks for a total of four sittings. An objective score was calculated for each patient using the Goodman and Baron scale to evaluate the outcome every visit during treatment and then 3 months after completion of therapy. Results: In group A, the percentage reduction in the mean objective scores was found to be 64%. In group B, the percentage reduction in mean objective scores was found to be 42%. Most of the changes were seen in the boxcar and rolling types of scars. Conclusions: Subcision and fractional CO2 laser were considered superior over subcision with microneedling fractional (RF) technique for the treatment of post-acne scars. Boxcar and rolling types of scars showed a high response to treatment than icepick scars Keywords: Acne scar, Fractional ...


Research Article of American Journal of Dermatological Research and Reviews Chronic urticaria versus dermatomyositis in a case of T- cell large granular lymphocytic leukemia Floria Bertolini MD1*, Luigi Clauser, MD2 1Rovigo City Hospital-Dermatological Clinic Via G. Falcone, P. Borsellino, 69 45100 Rovigo, Italy. 2Istituto Stomatologico Italiano, Via Pace, 21-20122 Milano, Italy. Aim: The reported case involved a complicated diagnostic path, not only because of the usual difficulties specific to chronic urticaria but, also because the trigger was a T-cell large granular lymphocytic leukemia (T-LGLL), a rare type of leukemia with an indolent course whose etiology is still not well known. This leukemia is also known for its propensity to cause autoimmune diseases. The aim of this study was to identify whether the muscle damage was caused by dermatomyositis or by T-LGLL. Methods: After elevated muscle enzyme levels had been discovered magnetic resonance imaging (MRI) revealed muscle damage. Consequently, a muscle biopsy was performed in a targeted manner. In addition to muscle biopsy, transmission electron microscopy and anti-CN1A antibody testing were performed. Results: MRI of the lower limbs and pelvic girdle indicated moderate fibroadipose substitution in many muscles, moderate edema in others. No involvement of the shoulder girdle and upper limbs. Histological examination of the muscle fibers showed an “inflammatory myopathy with isolated phagocytotic fibers.” Inclusion-body myositis, which is known to be associated with chronic T-LGLL was excluded. On the same biopsy transmission electron microscopy confirmed inflammatory myopathy and anti-CN1A antibodies were positive. DNA extracted from the muscle of the micro-rearrangement for the y-chain of the TCR identified on the DNA extracted from peripheral blood was positive. Conclusions: Conclusions: Chronic urticaria was an indication of immunoproliferative disease. Myositis was the pathology due to T-LGLL, and dermatomyositis was excluded. Keywords: Chronic urticaria, myositis, immunoproliferative disease, T- cell large granular lymphocytic leukemia, muscular ...


Research Article of American Journal of Dermatological Research and Reviews Effectiveness of Hormone Based Therapies (Spironolactone and Combined Oral Contraceptives in the Management of Acne Vulgaris in Women: A Systematic review and meta-analysis Yulita Herdiana*, Asih Budiastuti, Puguh Riyanto, Diah Adriani Malik, Retno Indar Widayati, Muslimin, Hardian Department of Dermatovenereology, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Dr. Sutomo Street No. 16, Semarang, Indonesia. Department of Physiology, Faculty of Medicine, Diponegoro University Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous follicular unit that often occurs. Acne is a skin disorder that is not life-threatening but is mostly complained of because it is aesthetically disruptive, which can cause significant psychological problems for sufferers. The management of acne vulgaris in female patients has its challenges. There are many histories of failed therapy using conventional therapy, such as with antibiotics or isotretinoin, and female patients have a predisposition to the condition of androgen excess. Also, the increasing awareness about limiting the use of antibiotics to prevent resistance in dermatological cases, including acne vulgaris, encourages other treatment options in the female patient population, one of which is hormone-based therapy. A systematic review and meta-analysis were performed of randomized clinical trials assessing the effects of Hormone Based Therapies (Spironolactone and Combined Oral Contraceptives) in the management of Acne Vulgaris in Women. Methods: Medline Pubmed, Scopus, Cochrane Library, the reference list, conference proceedings, researchers in the field of eligible studies were searched. Ten studies (n=1906 sub-jects) were included in qualitative analysis, of which eight studies (n=1842 subjects) were included in the meta-analysis. The age of the participant was greater than 14 years old. Intervention using combined oral contraceptives (n=8) or oral spironolactone (n=2). Duration of intervention (minimum six months for COC and three months for SL) and outcomes of mean difference number ...

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American Journal of Dermatological Research and Reviews (ISSN:2638-1893; DOI:10.28933/AJODRR) is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Dermatological Research and Reviews (Indexing information).

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American Journal of Dermatological Research and Reviews