American Journal of Dermatological Research and Reviews


Research Article of American Journal of Dermatological Research and Reviews The Effectivity of pH 4 Emulsion on Skin Barrier Function in The Elderly: A Systematic review and meta-analysis Milka Wulansari Hartono*, Diah Adriani Malik, Retno Indar Widayati, Asih Budiastuti, Puguh Riyanto, Muslimin Department of Dermatovenereology, Faculty of Medicine, Diponegoro University / Dr. Kariadi Hospital, Jalan Dr. Sutomo No. 16 Semarang, Indonesia. Background: The pH of the skin surface is elevated in the elderly therefore it may cause impaired barrier function manifest as various cutaneous abnormalities, including xerosis, pruritus, dermatitis, and skin infections. Consequently, skin care products for the elderly should contain moisturizing ingredients which are formulated to normalize the skin surface pH. Application of pH 4 emulsion is potentially beneficial to improve barrier function in the elderly and promoting skin health. We aimed to determine the difference of effectiveness of pH 4 emulsion compared to identical non pH 4 emulsion on decreasing TEWL in the elderly. A systematic review and meta-analysis was performed of randomized clinical trials assessing the effects of pH 4 emulsion on skin barrier function in the elderly. Methods: Medline Pubmed, Scopus, ProQuest, Cochrane library,, the reference list, conference proceedings, researchers in the field of eligible studies were searched. Four studies (n=98 subjects) were included in qualitative analysis of which two studies (n=45 subjects) were included in the meta-analysis. The mean age of the participants was 71.1 years old. Interventions use the application of pH 4 water in oil emulsion (n=2) and pH 4 oil in water emulsion (n=2). Duration of intervention (24 hours-7 weeks) and outcomes of interest varied among included studies. Results: Pooling of data using random-effects model found lower TEWL score in the pH 4 emulsion than in non pH 4 emulsion, with no significant difference (overall effect mean difference -0.068, 95% confidence ...


Review Article of American Journal of Dermatological Research and Reviews Fall from GRASE: The Sunsetting of the Sunscreen Innovation Act Joseph C DiNardo, MS1*, Craig A Downs, PhD2 1Retired Personal Care Products Industry Toxicologist; Vesuvius, Virginia, USA 2Executive Director; Haereticus Environmental Laboratory, Virginia, USA. The 2020 Coronavirus Aid, Relief, and Economic Security (CARES) Act terminated the Sunscreen Innovation Act (SIA) that the Food & Drug Administration (FDA) uses to determine sunscreen actives as safe and effective for human use. The Act also nullified a recent FDA proposal that reclassified 14 organic sunscreen actives as either not safe for human use or requires more data before being used in humans. Most sunscreen actives were approved in 1978; since that time the FDA has determined that over the last 20 years several changes have occurred leading to a substantial increase in sunscreen usage and exposure that increases the potential health risks associated with their use. Based on the scientific literature for the actives reviewed, it is clear that the SIA is needed to assure that sunscreen and other over-the-counter drugs are safe and efficacious for human use prior to entering the marketplace. #Haereticus Environmental Laboratory has received funding from the U.S. Environmental Protection Agency and the U.S. Department of Interior, but this funding did not contribute and is no way associated with this study. Keywords: GRASE, Sunscreen Innovation Act ...


Research Article of American Journal of Dermatological Research and Reviews Assessment of efficacy and tolerability of fractional CO2 laser in the treatment of axillary hyperpigmentation Nevine A. Dorgham, Dina A. Dorgham Dermatology Department, Kasr Al Ainy Hospital, Cairo University,Egypt Background: Axillary hyperpigmentation is a common and troublesome complaint especially among dark-skinned women. It is believed to be a form of post-inflammatory hyperpigmentation and so far, there is no universally accepted treatment for the disorder. Objective: The aim of this study is to assess the efficacy of fractional CO2 laser in the treatment of axillary hyperpigmentation Patients and methods: Thirty Egyptian females with axillary hyperpigmentation were recruited. The severity of the condition was estimated by both self-assessment and expert dermatologist before treatment. Four sessions of fractional CO2 laser were done. Both the efficacy and complications were assessed by the patient and the dermatologist six month after the last session. Results: There was a statistically significant difference of percentage of improvement of pigmentation before compared to one month after treatment as detected by self-assessment (p value= 0.002) and the observer’s assessment (p value= 0.001). Conclusion: Fractional CO2 laser, in properly chosen parameters, is an effective method for the treatment of axillary hyperpigmentation. Keywords: Axillary hyperpigmentation, fractional CO2 laser ...


Research Article of American Journal of Dermatological Research and Reviews Combining 308-monochromatic excimer phototherapy with monthly IM triamcinolone acetonide for the treatment of resistant alopecia totalis Nabeel K. Alhamzawi Department of Dermatology, Diwaniyah Teaching Hospital, Diwaniyah, Iraq Background:   Treatment of resistant alopecia totalis AT is a major problem in general practice.  Some studies reported the use of either excimer-308 or intra-muscular triamcinolone acetonide as a monotherapy, with conflicting results. Objective: To evaluate the therapeutic effect of combining 308-excimer phototherapy and intramuscular triamcinolone acetonide for the treatment of alopecia totalis. Methods and Material: Ten patients with alopecia totalis were evaluated in this prospective interventional study. All patients were assigned to receive the thera-peutic regimen that includes monthly IM triamcinolone acetonide (TAC) for a maximum of six pulses and twice-weekly excimer phototherapy for 24 sessions. Results:  The overall response rate for this regimen was 90%, with four patients 40% achieving complete regrowth of hair (100%). Three patients have exhibited a satisfactory response (>70% regrowth). Unsatisfactory response ( >10-< 70% regrowth) was reported in two patients . Younger patients responded better, as did those with a shorter history of the disease P < 0.05.  At follow-up, which continued for 8–12 months, recurrence was noted in two (22.2%) of the nine responders. Conclusions:  Combining excimer phototherapy with triamcinolone acetonide showed a promising effect on resistant AT. This treatment modality was effective and well tolerated particularly in young patients. Keywords: Alopecia totalis, excimer light, Triamcinolone acetonide, Combined treatment ...

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American Journal of Dermatological Research and Reviews (ISSN:2638-1893; DOI:10.28933/AJODRR) is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Dermatological Research and Reviews (Indexing information).

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American Journal of Dermatological Research and Reviews