American Journal of Dermatological Research and Reviews


Dermatological adverse events of immune checkpoint inhibitors

Review Article of American Journal of Dermatological Research and Reviews Dermatological adverse events of immune checkpoint inhibitors Kevin Yang1, Khurram Yusuf2 1Dermatology, UAB School of Medicine, Birmingham, AL 35294 2Kendriya Vidyalaya, Jabalpur, MP 482004, India Treatment with immune checkpoint inhibitors is a landmark in the treatment of melanoma and other cancers. These treatments have been very effective and have increased the survival of cancer patients. The promise of immunotherapy also comes with a variety of adverse events. One of the common sites of immune related adverse events (irAEs) is skin. The cutaneous irAEs present a unique challenge to the success of immunotherapy. It is important to diagnose and understand the mechanism related to these cutaneous irAEs to increase the effectiveness of immune checkpoint inhibitor therapy. In this review, we have characterized the various cutaneous irAEs associated with immune checkpoint inhibitor therapies and their possible mechanisms. Keywords:checkpoint inhibitors, immunotherapy, adverse events ...

The Cutaneous Manifestations Associated with COVID-19: A review

Review Article of American Journal of Dermatological Research and Reviews The Cutaneous Manifestations Associated with COVID-19: A review Ahmed, H MD, Yusuf, N PhD, MSPH University of Alabama at Birmingham, Department of Dermatology Importance: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic spreads, increasing cases of dermatologic manifestations of the disease continue to be reported. Observations: In this general review of the case reports, case series, and other systematic reviews on this subject, several patterns of cutaneous lesions have been compiled. These include viral exanthems, papulovesicular, pernio-like, vasculopathy-related, and other miscellaneous rashes. Conclusions and Relevance: While clinical observations and subjective cases of rashes associated with SARS-CoV-2 are important to furthering our research and study of this viral disease, we as clinicians must be cautious in attributing causation with correlation. Continued research and study are needed before we can attribute a source for these dermatologic manifestations. Funding: This research was partially support by IMPACT funds to NY from the School of Medicine, University of Alabama at Birmingham. Keywords: Dermatology, Rash, Cutaneous, morbilliform, viral exanthem, pernio, chilblains, urticaria, varicelliform, SARS-CoV-2, COVID-19, Coronavirus Disease 19 ...

Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil

Research Article of American Journal of Dermatological Research and Reviews Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil 1Professor Adil A. Noaimi MD, DDV, FICMS., 2Douaa S. Ahmed MD. 1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq. Background: Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa in the general population. Multifactorial etiopathogenesis has been suggested to explain the cause of RAS but the exact etiology and pathogenesis still unknown. Its therapy whether topical or systemic can induce clearance but the relapse rate is high. Objective: To evaluate the efficacy and prophylactic effects of topical Sesame seed oil in comparison with Pumpkin seed oil in the management of recurrent aphthous stomatitis. Patients and Methods: This is a single, blinded, clinical, therapeutic, comparative study where 35 patients with early onset RAS were examined in Center of Dermatology -Baghdad Teaching Hospital, Medical City ,Baghdad, Iraq from April 2018-October 2019. All socio-demographic data related to the disease was obtained from each patient, in addition to clinical examination was performed for each patient. Patients were divided into 2 groups: Group A (15 patients) used crude Sesame seed oil twice daily. Group B (20 patients) was instructed to use Pumpkin seed oil in a similar way to Group A. Short term assessment of each patient of  both groups was done to evaluate the therapeutic effect of drug by using oral clinical manifestation index (OCMI). A long term assessment was done for each patient to assess the prophylactic effect of drug by using OCMI before, after 1, 2 and 3 months of therapy. They were ...

Topical Therapy of Vitiligo Using Sunlight Exposure with Lactic Acid Cream (10%) Versus Methoxsalene Solution

Research Article of American Journal of Dermatological Research and Reviews Topical Therapy of Vitiligo Using Sunlight Exposure with Lactic Acid Cream (10%) Versus Methoxsalene Solution 1Khalifa E. Sharquie, 2Wesal K. Aljanabi, 3Tamara Qais Al-Mohammedi 1Professor, MD; PhD., Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2MD; FIBMS. Dermatology Center; Medical City, Baghdad, Iraq. 3MBChB, Dermatology Center; Medical City, Baghdad, Iraq. Background Vitiligo is a common autoimmune disease to which multiple therapies have been used. Lactic acid in different modes of preparation like 15% topical solution and 1% intralesional injection has been tried effectively in treatment of vitiligo. Objectives to test the efficacy of lactic acid cream10% with sunlight exposure in treatment of vitiligo, and to be compared with topical methoxsalene solution with sunlight exposure. Materials and Methods This is an interventional, therapeutic, single blinded, comparative study that was conducted in the Center of Dermatology, Medical City, Baghdad, Iraq, between April 2018 and June 2019. Patients with generalized and localized vitiligo were included. The diagnosis of vitiligo was based on clinical characteristic loss of skin pigmentation and supported by woods light examination. The demographic features were recorded. Physical examination was done to determine the site and number of patches per patient. The patients were divided into two groups: group A patients, were treated with lactic acid 10% cream followed by sunlight exposure. While in group B, the patients were treated with topical methoxsalene solution followed by sunlight exposure. All patients were assessed, and the surface area of each patch was measured before starting the treatment and every month for 3 months of treatment. The side effects were also recorded. A follow up visit after 3 months was done. A reduction rate in the surface area ...

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American Journal of Dermatological Research and Reviews (ISSN:2638-1893; DOI:10.28933/AJODRR) is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Dermatological Research and Reviews (Indexing information).

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American Journal of Dermatological Research and Reviews

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