American Journal of Dermatological Research and Reviews


TOPICAL TREATMENTS TO REDUCE SEVERITY OF RADIATION DERMATITIS IN BREAST CANCER PATIENTS-A SYSTEMATIC REVIEW

Review Article of American Journal of Dermatological Research and Reviews Topical treatments to reduce severity of radiation dermatitis in breast cancer patients-a systematic review Tania Nakra; Bunmi Ibrahim School of Allied Health Sciences. De Montfort University, Leicester. United Kingdom. Breast cancer (BC) patients are likely to undergo radiotherapy (RT) treatment which may lead to the development of the skin toxicity, radiodermatitis (RD). The purpose of this systematic review is to evaluate the effectiveness of topical interventions in reducing the severity of RD in females BC patients. Appropriate clinical studies were independently identified through a bibliographic search in PubMed and clinicaltrials.gov. Nine randomised, controlled clinical trials (RCTs) which stated a clear inclusion and exclusion criteria, were included in this review. The studies included in this review were conducted in the last 10 years and researched the effectiveness of only topical therapies on female BC patients. The severity of RD starting at baseline 0 to endpoint was measured using the Radiation Therapy Oncology Group (RTOG) scale, and results show most patients experienced a RTOG score change of 0-1 or 0-2. A significant relationship between results obtained from 0-1 and 0-2 was shown (p < 0.00001). Results suggest Radioskin 1&2 cream is the most effective topical treatment for RD as 95% of patients experienced a RTOG score change of 0-1 compared to 5% experiencing 0-2. However, controlled treatments like general care and Aqua Cream seem to be the least effective, as 1.9% of patients administrating general care experienced a RTOG score change of 0-1 compared to 41.9% experiencing 0-2. Keywords: Breast cancer; Radiotherapy; Radiodermatitis; Topical Treatments ...

STABILITY OF CHEMICAL UV FILTERS IN SUNSCREENS EXPOSED TO VEHICLE CABIN TEMPERATURES

Research Article of American Journal of Dermatological Research and Reviews Stability of chemical UV filters in sunscreens exposed to vehicle cabin temperatures Leslie K. Dennis 1, 2, *, Alesia M. Jung1, Kelly A. Reynolds2,3, Chiu-Hsieh Hsu1, Leif Abrell 4,5 1Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.2University of Arizona’s Environmental Exposure Science and Risk Assessment Center (ESRAC), Tucson, AZ, USA.3 Department of Community, Environment & Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.  4Department of Chemistry and Biochemistry, College of Science, University of Arizona, Tucson, AZ, USA.5Department of Environmental Science, College of Agricultural and Life Sciences, University of Arizona, Tucson, AZ, USA. Background: Sunscreen companies recommend replacing your chemical sunscreen every year.  Consumer inquiries about product integrity under excessive exposure to heat prompted the FDA to add a requirement statement to sunscreen products indicating a need to protect stored sunscreen from excessive heat and direct sun. If heat exposure indeed affects chemical sunscreen stability, then in some areas, replacement may be warranted earlier than a year. Methods: We examined real-life scenarios related to the storage of sunscreen containers inside vehicles sitting in natural sunlight to provide information about the stability of sunscreen active ingredients under real-life storage conditions.  The active ingredients avobenzone, oxybenzone, homosalate, octinoxate, octisalate, and octocrylene in samples of sunscreens were examined after heat exposure over six months using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.  The calculated levels of each active ingredient were then compared between the non-heat exposed samples and the heat exposed samples using a paired t-test to look for decreases in active chemicals from heat exposure. Results: No important differences were seen for heat exposure in this study of 378 hours of temperatures above 37.8 °C, with ...

NECROTIZING FASCIITIS AT THE EXTREMITIES AND ITS MANAGEMENT

Research Article of American Journal of Dermatological Research and Reviews Necrotizing fasciitis at the extremities and its management Hatim ABID1*, Mohammed EL IDRISSI1, Abdelhalim EL IBRAHIMI1, Abdelmajid ELMRINI1, Nissrine AMRAOUI2, Sara ELLOUDI2, Hanane BAYBAY2, Fatima Zahra Mernissi2 1Department of osteoarticular surgery B4, HASSAN II teaching hospital, Fes, Morocco. 2Department of dermatology HASSAN II teaching hospital, Fes, Morocco. We report in the light of a literature review the results of 28 patients treated for Necrotizing Fasciitis (NF) at the extremities between 2012 and 2017 with a view to a prospective study with longer following up and a greater number of patients. Keywords: Necrotizing Fasciitis; extremities; treatment ...

COMPARISON OF THE EFFICACY OF SUBCISION WITH FRACTIONAL CARBON DIOXIDE LASER VERSUS SUBCISION WITH MICRONEEDLING FRACTIONAL RADIOFREQUENCY IN THE TREATMENT OF ATROPHIC POST ACNE SCARS

Research Article of American Journal of Dermatological Research and Reviews Comparison of the efficacy of Subcision with Fractional Carbon Dioxide Laser versus Subcision with Microneedling Fractional Radiofrequency in the Treatment of Atrophic Post acne Scars Nabeel K. Al-Hamzawi Department of Dermatology, Al-Diwaniyah Teaching Hospital, Diwaniyah, Iraq Background: Many interventions have been used to treat post-acne scars, with various degrees of efficacy and adverse reactions. Multimodal approach can achieve better results for improving the physical appearance that even if minor may result in significant distress and reduced quality of life. Objective: To compare the efficacy of subcision with fractional carbon dioxide (CO2) laser and subcision with microneedling fractional radiofrequency (RF) in treating post-acne scars and to study their adverse effects. Methods: In this prospective, interventional clinical study, a total of 64 patients with post-acne scars were enrolled. The patients were randomly allocated into two groups of 32 patients each, in which group A was treated with subcision plus fractional carbon dioxide laser (CO2) and group B was treated with subcision plus microneedling fractional radiofrequency (RF) every 6 weeks for a total of four sittings. An objective score was calculated for each patient using the Goodman and Baron scale to evaluate the outcome every visit during treatment and then 3 months after completion of therapy. Results: In group A, the percentage reduction in the mean objective scores was found to be 64%. In group B, the percentage reduction in mean objective scores was found to be 42%. Most of the changes were seen in the boxcar and rolling types of scars. Conclusions: Subcision and fractional CO2 laser were considered superior over subcision with microneedling fractional (RF) technique for the treatment of post-acne scars. Boxcar and rolling types of scars showed a high response to treatment than icepick scars Keywords: Acne scar, Fractional ...

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American Journal of Dermatological Research and Reviews

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