American Journal of Orthopedic Research and Reviews


Single-cell transcriptome analyses profile tissue macrophages in the human osteoarthritis

Research Article of American Journal of Orthopedic Research and Reviews Single-cell transcriptome analyses profile tissue macrophages in the human osteoarthritis Jingbin Zhou1,2, Zhihong Zhao3, Chen He1, Feng Gao1, Yu Guo3, Feng Qu4, Yujie Liu1 1Medical School of Chinese PLA, Beijing 100853, China. 2Chinese National Institute of Sports Medicine, Beijing 100061, China. 3Department of Orthopedics, Beijing Second Hospital, Beijing 100031, China. 4Beijing Tongren Hospital, Capital University of Medicine, Beijing 100730, China. Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and in relatively low-grade, mainly mediated by the innate immune system, especially macrophages. However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition. Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages. We also compared the gene expression profiles of macrophages in healthy people and OA patients, and found the characteristic changes of special macrophages in the OA knee. We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies. Keywords: Single-cell transcriptome analyses, tissue macrophages, human osteoarthritis ...

INTEREST OF THE FEMORALE FIXATION USING THE ULTRABOUTON IN THE ARTHROSCOPIC RECONSTRUCTION OF THE ACL (Anterior cruciate ligament) TECHNIQUE DIDT

Research Article of American Journal of Orthopedic Research and Reviews INTEREST OF THE FEMORALE FIXATION USING THE ULTRABOUTON IN THE ARTHROSCOPIC RECONSTRUCTION OF THE ACL (Anterior cruciate ligament) TECHNIQUE DIDT J.Amghar, M. Yahyaoui, M. Benhammou, S. Aharram, O. Agoumi, A. Daoudi Orthopedic Trauma Department A, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Mohammed Premier University, Oujda, Morocco. The previous chronic instability of the knee is a secondary progressive disease in the break of the previous crossed ligament (LCA) hiring the functional forecast of the lower and compromising limb sports activity. The objective of our job is to assess the clinical results of the surgical treatment of the breaks of LCA according to the Technology of DIDT under arthroscopie with a femoral fixing by the system of the ultrabutton and to analyse the interest of this last in international series and magazine of literature We report a series of 17 patients who introduced a previous chronic laxity, performed by arthroplasty of the hamstrings tendon (right internal DIDT - half tendon) arthroscopy of ACL, collected over a period of 12 months. Femoral fixation was provided by the endobutton system. After a medium detachment of 8 months, and according to the score of objective International Knee Material Committee (IKDC) the total score of IKDC showed 91 % of our patients belonging to the group A, 7 % in the group B, 2 % to the group C and 0 % to the group D. Keywords: Reconstruction of the previous crossed ligament; sinews DIDT; femoral Fixing; Endobouton, Ultrabutton ...

PURE INTERNAL SUBTALAR DISLOCATION: ABOUT A CASE

Case Report of American Journal of Orthopedic Research and Reviews PURE INTERNAL SUBTALAR DISLOCATION: ABOUT A CASE J.Amghar, M. Yahyaoui, M. Benhammou, S. Aharram, O. Agoumi, A. Daoudi Service de chirurgie orthopédique et traumatologique A, CHU Mohammed VI-Oujda Subtalar dislocations are uncommon limb lesion representing 1% of all dislocations that occurs in polytraumatism context. We here report the case of a young patient presenting with sports-related internal astragalo-scapho-calcaneal dislocation. The patient underwent orthopedic treatment with good clinical and radiological outcome Keywords: Internal subtalar dislocation, pure, sport accident ...

BIOPHYSICAL AND BIOCHEMICAL MODULATORS ASSOCIATED WITH HEALING OF THE OSSEOUS TISSUE

Review Article of American Journal of Orthopedic Research and Reviews BIOPHYSICAL AND BIOCHEMICAL MODULATORS ASSOCIATED WITH HEALING OF THE OSSEOUS TISSUE Mateus Porfírio Rodrigues 1*, Ingrid Larissa da Silva Laurindo2, Adalgiza Suellen da Silva Prado3, José Carlos Nogueira Nóbrega Júnior4, Jéssica Andréia Pereira Barbosa5, Marllon Alex Nascimento Santana6 1,2,3 Estudantes do curso de Bacharelado em Fisioterapia – FACOTTUR, 4,5,6 Docente/Pesquisador do Curso de Fisioterapia – FACOTTUR Introduction: Fracture is a bone loss that can be discovered by pathological factors, congenital diseases, avitaminosis or even surgeries, and the cicatricial process as recovery of tissue stability. We have the possibility of assisting in the healing of the bone tissue of biochemical and biophysical modulators, from the use of hydroxyapathy, chitosone, ultrasound and cryotherapy. Objective: This literature review aimed to discuss the characteristics of bone tissue, its regeneration and the main biochemical and biophysical treatments without the use of auxiliary agents in the cicatricial process. Methodology: A research of data on PubMed, SciELO, LILACS, Journal of Cell Science and the Ministério da saúde was done through the keywords “Bone healing”, “Modulators” and its components in Portuguese and English, in the last 10 years. 92 articles were found, with 43 articles selected. Results: According to the studies of literary bases, the biochemical and biochemical ones were constituted and are great auxiliaries in the cicatricial process of the bone tissue. Conclusion: Evidence in the literature has shown that modulators can reduce the time of regeneration of bone tissue. Keywords: Bone Histogenesis, Healing, Cicatricial Modulators ...

Dr. Karol Szyluk
District Hospital of Orthopedics and Trauma Surgery. b41-940 Piekary Śląskie, Bytomska 62 str. POLAND

Dr. RAÚL GONZÁLEZ-GARCÍA
Department of Oral and Maxillofacial-Head and Neck Surgery, University Hospital Infanta Cristina, Avenida de Elvas s/n, 06080, Badajoz (Spain)

Dr. Maher SALAMOON
Department of Medical Oncology Al Bairouni University Hospital, Ex-specialist in Lyon-sud Hospital Department of Hematology Lyon-france

Dr. P. ShnamugaRaju
Assoc.Professor & I/C Head, Department of Physical Medicine & Rehabilitation, Chalmeda AnandRao Institute of Medical Sciences, Karimnagar-505001 Telangana, India.

Dr. Yousif Mohamed Y. Abdallah
Professor (Assistant), Radiological Science and Medical Imaging Department, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia

Dr. Can SARICA
Adiyaman University School Of Medicine, Department Of Neurosurgery, Adiyaman

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1.SENHAJI Said; ABDULRAZAK Saeed; KACIMI ALAOUI Mehdi ; EL IDRISSI Mohamed ; EL IBRAHIMI Abdelhalim ; EL MRINI Abdelmajid Intramuscular myxoma of the thigh: a rare case report.American Journal of Orthopedic Research and Reviews, 2018, 1:6. DOI:10.28933/ajorr-2018-06-2401 
2.Melo, M.C.F, Macêdo, T.S, Oliveira, J.C, Araújo, M.G.C, Vidal, A.K.L.Interrelationship Between Rheumatoid Arthritis and Periodontitis.American Journal of Orthopedic Research and Reviews, 2018, 1:4 

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American Journal of Orthopedic Research and Reviews is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Orthopedic Research and Reviews  (Indexing information).

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American Journal of Orthopedic Research and Reviews

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