Recent Articles

Peer-to-peer (P2P) lending is a new mode of alternative finance, allowing borrowers and lenders to transact through Internet platform without traditional intermediaries. This review focus on reviewing the P2P lending’s business models, risks and regulation.

Exposure to acute anoxic stress produces deleterious effects on the brain through the formation of oxidant molecules like reactive oxygen species. Thus, compounds with antioxidant property might demonstrate protective effect against the damaging effects of anoxic stress on brain cells. This study was carried out to evaluate the protective effect of Cymbopogon citratus, a medicinal plant with antioxidant property on convulsions induced by anoxic stress in mice. Male Swiss mice (20-22 g) were given C. citratus (25, 50 and 100 mg/kg, p.o), Panax ginseng (50 mg/kg, p.o) or vehicle (10 mL/kg p.o). Thirty minutes later, the animals were exposed to anoxic stress and the latency (s) to convulsion (anoxic tolerance time) was measured. Thereafter, the blood glucose level was measured using glucometer. The levels of malondialdehyde (MDA) and glutathione (GSH) were also determined in the brain homogenates of mice subjected to anoxic stress. C. citratus (25, 50 and 100 mg/kg, p.o) did not significantly (p > 0.05) delay the latency to anoxic convulsion and also failed to alter the brain concentrations of MDA and GSH in mice exposed to anoxic stress. However, C. citratus (25, 50 and 100 mg/kg, p.o) caused a significant and dose-dependent reduction in the blood glucose levels in anoxic stressed mice. These findings suggest that C. citratus has neither protective effect against convulsive episodes nor alter oxidative stress parameters induced by acute anoxic stress in mice. The decrease in blood glucose produced by C. citratus in anoxic condition may be unconnected with normalization of deregulation of plasma glucose level during stress responses.

Dominant-Intermediate Charcot-Marie-Tooth disease is one of the most common inherited disorders affecting the peripheral nervous system. Pleckstrin homology domain mutations in dynamin 2 cause dominant-intermediate Charcot Marie Tooth Syndrome. Autophagy in normal cells helps to maintain homeostasis and degrade damaged or old organelles and proteins. Here we link the pleckstrin homology domain mutants and the disease state to autophagy. Cells over-expressing the K558E mutation in the pleckstrin homology domain of dynamin 2 have shown an increase in expression of ER stress and autophagy markers. Although the exact link between autophagy and peripheral neurodegeneration has yet to be fully elucidated, these results set the foundation for further research into the interactions between dynamin 2 mutations, autophagy, and Dominant-Intermediate Charcot-Marie-Tooth.

In this review article the author argues that complete presentation of various Indian diet can reduce the stress and related mental and physical illnesses like Stress anxiety, depression etc.. Life is neither Possible to overcome safely.