International Journal of Bioscience and Medicine


Review Article of International Journal of Bioscience and Medicine Antioxidant Activity and Hemotoxicity of Medicinal Plant of the Caatinga Domain: Amburana Cearensis (Fabaceae) João Victor de Oliveira Alves1*, Francisco Henrique da Silva1, Maria Victoria dos Santos Alves Evaristo2, Janderson Weydson Lopes Menezes da Silva3, Paloma Maria da Silva1, Larissa Gomes de Arruda1, Irivânia Fidelis da Silva Aguiar1, Saulo Almeida de Menezes1, Fálba Bernadete Ramos dos Anjos4, Márcia Vanusa da Silva1 1Biochemistry Department, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil; 2Graduated in Biological Sciences, Institute of Biological Cienicas, Campus Santo Amaro, Universidade de Pernambuco; 3Aggeu Magalhães Institute (IAM) - FIOCRUZ/PE, Brazil. 4Department of Histology and Embryology, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil Amburana cearensis is a medicinal species popularly known as “cherry” or “aroma amburana” that has wide distribution in South America, being characteristic of Seasonal Forests. It also occurs in Semideciduous Seasonal Forest, restricted to rocky or limestone outcrops; in Submontane Deciduous SubmontanaSeasonalForest; in Dense Ombrophilous Forest (Atlantic Forest) and even in caatinga/dry forest. Taking into account the growing interest in the search for agents that act in the face of oxidative stress, without causing toxic effects to biological systems, the present study aimed to investigate the phytochemical composition and evaluate the antioxidant and hemotoxic activities in vitro of the aqueous extract obtained from the shells of Amburana cearensis (EAAc). Hemaglutination wasevaluated for human erythrocytes collected from people with the presence of O+ blood. In the face of the tests, Amburana cearensis presented significant results for antioxidant activity without causing erythrocyte hemolysis, highlighting the importance of the species as a source of antioxidant agents, which are recognized for blocking the evolution and acting to combat symptoms triggered by diseases associated with oxidative stress. Keywords: Caatinga. Aqueousextract. Erythrocytes. Free radicals ...


Review Article of International Journal of Bioscience and Medicine EXECUTIVE FUNCTION: COGNITIVE DEVELOPMENT, ADOLESCENCE AND DRUG ABUSE Aparecido Jonanthan Mandú de Araújo¹*, Caio Matheus Santos da Silva Calado¹, Danielle Dutra Pereira¹, Juliana Marina Campelo² e Jennifer Hellen Melo Sobral². ¹ Universidade Federal de Pernambuco.² Centro Universitário Maurício de Nassau. Introduction: Neuroscience brings advances and revelations of specificities and functionalities of the nervous system, contributing to the understanding of the exposure influences of neuroanatomic structures in various physiological and behavioral factors. Given this, it is known that executive functions are modeled as the most diverse forms of social interaction and are closely linked to the prefrontal lobe. These skills are consolidated only in adulthood. In this sense, the nervous system in adolescence is subject to changes in its development for social and cultural reasons. Objective: In this sense, the aim of this study is to analyze the use and abuse of recreational drugs that act on the nervous system and their influence on executive functions and cognitive development during adolescence. Methodology: The methodology used was a literature review of the integrative type in the PUBMED and ScieELO databases published in the last 10 years. Results and discussions: The use of alcohol, marijuana and inhalants are causative agents of cognitive impairment, especially in processing speed and response and working memory during adolescence, but results are still controversial as information such as dosage is lacking. , time of use and time of abstinence of users. Final Considerations: The results showed controversies in the performance of these substances in neurobiological bases and their long term damages; Therefore, further longitudinal studies are needed to monitor the cognitive development of these diseases and cognitive impairment and its consequences in adulthood. Keywords: Neurophychology. Cognitive Desenveloped. Executive System. Drug ...


Research Article of International Journal of Bioscience and Medicine EVALUATION OF PERIODONTAL DISEASE IN RATS SUBMITTED TO THE ADMINISTRATION OF CYTHOCBACTERIA ARTHROSPIRA SP. ("SPIRULINA SP.") AS A FUNCTIONAL SUPPLEMENT Ana Luiza Batista de Lima1, Carina Scanoni Maia2, Luciana Maria Silva de Seixas Maia3, Danielli Matias de Macêdo Dantas4, José de Castro Neto Júnior5,Juliana Pinto de Medeiros*6 1,2,3,6Universidade Federal de Pernambuco, Departamento de Histologia e Embriologia. 4Unidade Acadêmica de Serra Talhada da UFRPE, 5Universidade Federal do Rio Grande do Norte. Objective: To evaluate the therapeutic effect of cyanobacteria Arthrospira sp. in the evolution of periodontal disease. Methods: Eight rats, aged 90 days weighing 280 ± 300g, were used from the Animal Experimentation Center Animal Hospital of the Department of Pharmaceutical Sciences of the Federal University of Pernambuco. After an adaptation period of 10 days, the animals were randomly divided into three groups, namely: Group I - Control Rats, without administration of cyanobacteria; Group II - Rats with periodontal disease without administration of cyanobacteria; Group III - Rats with periodontal disease with cyanobacteria administration. All animals were induced to periodontitis, which was made by ligature with cotton thread, and this wire was placed around the gingival sulcus of the left upper first molar, with this application there was accumulation of residues, causing the formation of dental biofilm. Results: After the morphological analysis of the experimental groups, we observed that there was a significant effect among the studied groups, where the periodontal ligament was preserved (treated group) or showed absence of tissue integrity (untreated group). Conclusion: The administration of Arthrospira sp. in rats with periodontal disease, suggests to be an important ally in the fight against the progression of periodontitis, thus acting in the control of this disease. Keywords:periodontal disease, rats, spirulina, functional supplement ...

Phytochemical profile and cytotoxic activitys of Zanthoxylum tingoassuiba A. St. Hil extract

Research Article of International Journal of Bioscience and Medicine Phytochemical profile and cytotoxic activitys of Zanthoxylum tingoassuiba A. St. Hil extract Francisco Henrique da Silva1 *, Amanda Virgínia Barbosa1, João Ricardhis Saturnino de Oliveira1, Matheus Alves Siqueira de Assunção2, Fálba Bernadete Ramos dos Anjos2, Márcia Vanusa da Silva1 1Biochemistry Department, Federal University of Pernambuco, Recife, Pernambuco, Brazil. 2Department of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil The Caatinga phytogeographic domain represents 11 % of the Brazilian territory and presents a plant singularity that is not described anywhere else in the world. From this perspective, this study aimed to evaluate the phytochemical and cytotoxic profile of the aqueous extract of the plant species Zanthoxylum tingoassuiba A. ST. Hil, in addition to the evaluation of the photoprotective activity. The methodology used for these analyzes consisted of the collection and determination of secondary compounds of the species, by thin layer chromatography, in addition to the evaluation of the cytotoxic activity by different methods, as well as the evaluation of the photoprotective activity by spectrometry. As a result, it was noticed that the extract did not present erythrocyte hemolysis, as well as cytotoxicity by MTT in relation to the controls. Keywords: Caatinga; Cytotoxic; Evaluation ...

Dr Charles Fokunang
Professor&Director of Student’ Affairs, The University of Bamenda; Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1.

Dr. Moustafa M. Zeitoun
Professor, Department of Animal Production, Faculty of Agriculture, University of Alexandria, El-Shatby, Alexandria, Egypt; Department of Animal Production and Breeding, College of Agriculture and Veterinary Medicine, Qassim University

Professor, Department Of Chemistry, Sri Vidya Nikethan Engineering College.Tirupathi ,INDIA

Dr Viraj H Mankar
Assistant Professor, Lovely Professional University

Dr Kasim S. Abass
Assistant Professor, College of Nursing, University of Kirkuk

Dr Shriram Kunjam
Assistant Professor, Department of Botany, Government V.Y.T. P.G. Autonomous College

Dr. Mario Bernardo-Filho
Professor Titular, Universidade do Estado do Rio de Janeiro

Dr. Pongsak Rattanachaikunsopon
Associate Professor, Department of Biological Science, Faculty of Science, Ubon Ratchathani University

Dr. Dhananjay Kumar Singh
Molecular Bio-prospection Department, CSIR-CIMAP

Dr Mohammad Hadi Dehghani
Professor, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences

Dr. Parichat Phumkhachorn
Assistant Professor, Department of Biological Science, Faculty of Science, Ubon Ratchathani University

Dr. Vandna Kukshal
Department of Internal medicine, Washington University School of Medicine

Dr. Ritika Das 
Skirball Institue for Biomolecular Science at NYU Langone Medical Center

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1.Kaouthar Samarat, Sho Hanida, Shigeru Ishikawa, Kazunori Kotani, Teruo Matsuzawa. Computational Fluid Dynamics Simulations of Chimpanzee Nasal Airflow for Different Respiratory Modes. International Journal of Bioscience and Medicine, 2018; 2:8. DOI: 10.28933/ijbm-2018-06-2001.
2.Feng HE, Mi-mi ZHANG, Li-hong ZHANG and Qing-ping HU. Response surface methodology for the optimization of chlorpyrifos-degrading conditions by Pseudomonas stutzeri ZH-1. International Journal of Bioscience and Medicine, 2018; 2:7. DOI: 10.28933/ijbm-2018-01-0801

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International Journal of Bioscience and Medicine