International Journal of Case Reports


Surgical difficulties with a giant carcinoid in the anterior mediastinum

Case Report of International Journal of Case Reports Surgical difficulties with a giant carcinoid in the anterior mediastinum Miklos Boros MD1*, Ulf Hermansson MD1, Ingemar Vanhanen PhD1 1Department of Cardiothoracic Surgery, University of Linköping, Linköping, Sweden. Atypical carcinoid in the anterior mediastinum is a rare neoplasm. In our case the huge mediastinal carcinoid was treated with surgery using a median sternotomy and clamshell incision because of the extension of the tumor. We describe our difficulties under the surgery and take a look at the literature. Abbreviations: GP – general practitioner  PET - positron emission tomography CT- computed tomography MDT – multidisciplinary team Keywords: anterior mediastinum, giant carcinoid, surgery ...

A rare case of Hepatic Sinusoidal obstruction syndrome due to a drug use

Case Report of International Journal of Case Reports A rare case of Hepatic Sinusoidal obstruction syndrome due to a drug use Melike Ruşen Metin1,  Hasan Aydın2 1Specialist, TC.SB. Ankara Bilkent City hospital Radiology Department, ANKARA-TURKEY Tlf: 0090-312-5526000. 2Associate Professor, University of Health Sciences, TC.SB. Ankara Oncology Research hospital Radiology Department, ANKARA-TURKEY. Here, we report a case of hepatic sinusoidal obstruction syndrome(HSOS) of a 30 years old female patient with Ulcerative colitis(UC) who was being treated by mesalazine. The patient was admitted to the emergency unit by harsh and cramping abdominal pain, she had increased AST-ALT-Bilirubine and GGT levels in the blood laboratory analysis. In the Portal venous Doppler US; Splenomegaly and coarse granular appearance in liver parenchymal echogenecity were observed. In the abdominal CT, Splenomegaly was confirmed. In the Dynamic Abdominal MRI, pathognomonic liver finding which was the patchy contrast-enhancing reticular appearance, was visualized and the exact diagnosis was handled by true-cut biopsy. The aid of Dynamic Abdominal MRI to the early diagnosis of HSOS was also demonstrated in this case. Keywords: Hepatic; Veno-occlusive; Diseases; MRI; Mesalazine ...

15q11.2 Deletion Syndrome: Expanding the Phenotype

Case Report of International Journal of Case Reports 15q11.2 Deletion Syndrome: Expanding the Phenotype Luis F. Escobar1*, Rebecca Carr1, 2, Lauren Bogue1 1Medical Genetics and Neurodevelopmental Center. 2Peyton Manning Children’s Hospital at St. Vincent, Indianapolis, In 46260.  Purdue University, Lafayette, In 47907. Background: Although multiple reports exist in the literature of patients with 15q11.2 deletion syndrome, the variability of the phenotype has made clinical delineation difficult. Neuro-developmental scores have not been previously reported. We present clinical findings in a group of 16 patients referred to our center for evaluation and management of neurodevelopmental difficulties. Methods: All patients were seen in our center between 2005 and 2016. They were seen by a clinical geneticist and their diagnosis of 15q11.2 deletion syndrome was confirmed by a microarray analysis. Bayley Scales of Infant Development was done and provided a mental developmental index and a motor developmental index. The data collected was then compared to previous reports in the literature of patients with 15q11.2 deletion syndrome. Results: The reviewed group consisted of 10 males and 6 female patients between the ages of 3 and 15 years. The most common clinical findings included developmental delay (94%),  hypotonia (88%), ADHD (75%), anxiety (50%), feeding difficulties (44%), autism (31%), dolichocephaly (25%), 2-3 toe syndactyly (19%), seizure activity (19%), and congenital heart disease (13%).  Additional findings included prominence of the metopic suture, epicanthal folds, micrognathia, ankle torsion, incontinence, and sleeping difficulties.  Our developmental evaluation by the Bayley Scales of Infant Development indicated an average Mental Developmental Index of 75 (NL = >85) and Motor Developmental Index of 75 (NL = >85) in the patients less than 3 years old.  Close to 43% of patients had an occipitofrontal circumference (OFC) greater than or equal to the 97th. Conclusion: The data provided here intends to expand the phenotype of the 15q11.2 ...

A severe case of toxic epidermal necrolysis which started with agep-like features: Does a new clinical type of drug eruption?

Case Report of International Journal of Case Reports A severe case of toxic epidermal necrolysis which started with AGEP-like features: Does a new clinical type of drug eruption? Sevil Alan Akdeniz University School of Medicine Department of Dermatology and Venereology. Acute generalized exanthematous pustulosis (AGEP) and toxic epidermal necrolysis (TEN) are adverse cutaneous reactions. Despite the fact that these 2 cutaneous reactions differ in presentation, prognosis, pathologic features, and treatment, overlap can exist between them, creating a diagnostic challenge. It has rarely been reported that AGEP overlaps or mimics TEN, while TEN which starting by multıple pustules like AGEP has not been reported. The present study reports a rare case of a 14-year-old male patient with the clinical manifestations of multiple purulent bullae caused by amoxycillin ingestion. On 3. day dermatological examination revealed flaccid bullae and epidermal splitting with positive Nikolsky’s sign on right pectoral area, erosions on oral and anogenital mucosa. Histopathologic examination showed a massive inflammatory infiltration and epidermal necrosis indicated Steven Johnson syndrome. Later on added systemic symptoms with haemodynamic, respiratory imbalance and the patient was exitus. The case is discussed to reveal whether a new clinical pattern of drug eruption has been identified. We describe a patient with TEN who presented initially with clinical features of acute generalized exanthematous pustulosis (AGEP). To the best of our knowledge, one report drug eruption with purulent bulla and epidermal necrolysis has previously been documented, and therefore the present study is the second case report of its kind. Because the initial presentation of such adverse drug reactions may vary, diagnosis is difficult and dermatologists must careful the possibility of mimics among adverse cutaneous reactions. Keywords:  toxic epidermal necrolysis, AGEP-like features, case report ...

COVID-19 infection In Beta Thalassemia Major: Case series

Case Report of International Journal of Case Reports COVID-19 infection In Beta Thalassemia Major: Case series Lina Okar1*, Maya Aldeeb1, Rita Ahmad1, Mohamed A. Yassin2 1Department of Medical Education, Hamad Medical Corporation, Doha, Qatar. 2Department of Medical Oncology, Hematology Section, National Center for Cancer Care & Research, Hamad Medical Corporation, Doha, Qatar. COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pneumonia of unknown pathogen. Unfortunately, this novel virus continues spreading causing a pandemic. Thalassemia considered one of the most common hemoglobinopathies. Beta thalassemia is the commonest type with a variety in clinical picture due to the deference in homozygous. A lot of vulnerable categories were at high risk of getting infected with the coronavirus and more even its complication. Despite the conflicting data and ongoing research on this topic, thalassemia patients were categorized among the high-risk population. Here we present a case series describing the clinical progression of two splenectomised patients who has transfusion dependent beta thalassemia major. Keywords: COVID-19; Beta Thalassemia Major; Haemoglobinopathies; Splenectomy; blood transfusion ...

Dr. Xiaoning Luo
Professor, Department of Otorhinolarygology-Head and Neck Surgery, Guangdong General Hospital, Guangzhou, China

Dr. N.S. NEKI
Professor & Head, Dept.of Medicine, Govt. Medical College, Amritsar, India

Dr. Jitesh K. Kar
Clinical assistant professor, Department of Internal Medicine – Neurology, University of Alabama at Birmingham, Huntsville Regional Campus

Dr. Nisar Haider Zaidi
MBBS, MS, MRCS (Glasgow), FICS, FACS. Department of surgery, King Abdulaziz University Hospital , POBox-80215 Jeddah 21589 , Saudi Arabia

Dr. Giuseppe Lanza
Consultant Neurologist and Clinical Researcher, Department of Neurology IC of the “Oasi” Institute for Research on Mental Retardation and Brain Aging

Dr. Yousif Mohamed Y. Abdallah
Professor (Assistant), Radiological Science and Medical Imaging Department, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia

Dr. Karol Szyluk
District Hospital of Orthopedics and Trauma Surgery

Dr. Mohd Normani Zakaria
Chairman / Head of Hospital Unit / Assistant Professor / Consultant Audiologist, Audiology and Speech Pathology Programme, School of Health Sciences,, Universiti Sains Malaysia 

Dr. Dennis J. Mazur
Senior Scholar, Center for Ethics in Health Care, and Professor of Medicine, Oregon Health and Science University, Portland, Oregon USA

Dr. Marcos Roberto Tovani Palone
Department of Pathology and Legal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

Dr. Begum Sertyesilisik
Assoc. Prof. at the Istanbul Technical University

Dr. Jamunarani Veeraraghavan
Baylor College of Medicine, One Baylor Plaza, Houston, Texas 

Dr. Rajinder Pal Singh Bajwa
Niagara Falls Mem Med Center, Division of Infectious Diseases, 621 Tenth Street, Niagara Falls, NY

Dr. Can SARICA
Adiyaman University School Of Medicine, Department Of Neurosurgery, Adiyaman

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Aims
International Journal of Case Reports (ISSN:2572-8776; DOI:10.28933/IJCR) is a peer reviewed open access journal publishing case reports in all kinds of diseases of all medical fields. Our aim is to provide a platform for authors from all countries to encourages publication of most recent case reports in all specialties. 

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Peer Review help ensure the quality of the publications. Manuscripts of International Journal of Case Reports will be peer-reviewed by invited experts in the field. The decisions of editors will be made based on the comments of the reviewers.

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International Journal of Case Reports (ISSN:2572-8776; DOI:10.28933/IJCR) is a journal to support Open Access initiative

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Scope: (Case reports from all medical fields.)

  • Allergy and Its Subspecialties
  • Anesthesiology and Its Subspecialties
  • Physical Medicine and Rehabilitation and Its Subspecialties
  • Urology and Its Subspecialties
  • Emergency Medicine and Its Subspecialties
  • Dermatology and Its Subspecialties
  • Medical Genetics and Its Subspecialties
  • Internal Medicine and Its Subspecialties
  • Diagnostic Radiology and Its Subspecialties
  • Neurology and Its Subspecialties
  • Psychiatry and Its Subspecialties
  • Obstetrics and Gynecology and Its Subspecialties
  • Ophthalmology and Its Subspecialties
  • Surgery and Its Subspecialties
  • Pediatrics and Its Subspecialties
  • Nuclear Medicine and Its Subspecialties
  • Preventive Medicine and Its Subspecialties
  • Radiation Oncology and Its Subspecialties
  • Pathology and Its Subspecialties
  • Family Medicine and Its Subspecialties
  • Immunology and Its Subspecialties

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