International Journal of Hospital Pharmacy

Research Article of International Journal of Hospital Pharmacy Development and Validation of Analytical Methods to Determine the Prolonged in-use Stability of Anticancer Monoclonal Antibodies in Clinical Practice A. Hedvig Arnamo1, Dick Pluim1, Alwin D.R. Huitema1,2,3, Bastiaan Nuijen1, Jos H. Beijnen1,4 1.Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek hospital - Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; 2. Department of Clinical Pharmacy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands; 3. Department of Pharmacology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;  4. Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, David de Wied building, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands Background/purpose: Personalized dosing of monoclonal antibodies (mAbs) based on body weight and surface area may result in leftovers that need to be discarded due to the absence of stability data. After manufacturing, these mAbs undergo extensive quality control with a panel of methods. With some of these similar methods, these mAbs could be tested to see if stability is maintained after the opening of the pharmaceutical product vial and dilution for administration in a daily clinical setting. Prolonged in-use stability may reduce unnecessary waste and minimize the financial loss of these expensive drugs. Methods: Previously, based on extensive literature research, a complementary panel of methods was selected including visual inspection colour, apparency and, clarity (CAC), size exclusion chromatography (SEC), enzyme-linked immunosorbent assay (ELISA), dynamic light scattering (DLS), thermal denaturation (Tm), and aggregation (Tagg) determination, pH and dye ingress method. We evaluated, developed, and validated these methods with respect to the accuracy, precision, reproducibility, stability-indicating capability, carry-over, limit of quantification (LOQ) and limit of detection (LOD) for nivolumab and pembrolizumab as prototype anticancer mAbs. Results: Analytical results show that stability can be determined from a ...

Review Article of International Journal of Hospital Pharmacy Summary of the Clinical Pharmacist’s Role in the Management of Acute Pancreatitis: A Clinical Review Jad El Tom1, Alisar Serhan2, Tarek Safi3, Wissam K Kabbara4 1School of Pharmacy, Lebanese American University (LAU), Byblos, Lebanon; 2Hospital Pharmacist, Saint George Hospital University Medical Center, Beirut, Lebanon;3Saarland University Medical Center, Homburg, Germany; 4Clinical Associate Professor, Department of Pharmacy Practice, School of Pharmacy, Lebanese American University (LAU), Byblos, Lebanon. Introduction: The role of the clinical pharmacist in the management of acute pancreatitis has not been researched extensively, and only a few published studies on the topic can be found. This clinical review presents all pertinent published data and serves as a guide for clinical pharmacists who participate in the management of patients with acute pancreatitis. Methods: An extensive literature search was conducted on PubMed from 1990 to 2021 to retrieve relevant studies focusing on the role of the clinical pharmacist in the treatment of acute pancreatitis. Results: An analysis of the medications that are associated with acute pancreatitis is presented, highlighting the responsibility of the pharmacist to conduct a thorough medication investigation in order to identify a possible drug-induced acute pancreatitis. Medical management of acute pancreatitis, mainly fluid therapy, is an area where a clinical pharmacist can appropriately intervene. Proper choice of fluid therapy and its rate, nutritional considerations, pain management and antibiotic use, are all important to consider for a successful treatment with minimal adverse effects. It is well documented in the literature that clinical pharmacists can decrease hospital costs. Discharge counseling performed by a clinical pharmacist has been shown to increase patient compliance and decrease both readmission rates and follow-up physician visits. Conclusion: The clinical pharmacist, as the primary drug expert, can identify medication-induced pancreatitis, diminish the use of unnecessary antibiotics, improve patient care ...

Research Article of International Journal of Hospital Pharmacy Antibotics Which Distrbuted in the Hospital of Al Wahda (Derna, Libya) by Medical Supply Ward for 3 Months and Their Relations With Number of Patients Admitted and Compare These Antibiotics With Bacterial Culture Results Done by Laboratory Mahmoud El Mabri1, Abduljaleel el-shalwi2, Bilal B Rafadi3 1Medical Supply Ward Wahda Hospital, Faculty of Pharmacy. Benghazi University, Derna Libya; 2Medical Supply Ward Wahda Hospital, Faculty of Pharmacy. Omar Elmokhtar University; 3Benghazi University, Derna Libya Antimicrobial resistance (and particularly antibiotic resistance) is spreading now, and there are few prospects for the development of new classes of antibiotics in the short term. However, there is today considerable awareness of the need for, and political support for, action to combat Antimicrobial resistance1. Surveillance of antimicrobial use tracks how and why antimicrobials are being used and misused by patients and healthcare providers. Monitoring antimicrobial prescription and consumption behavior provides insights and tools needed to inform therapy decisions, to assess the public health consequences of antimicrobial misuse, and to evaluate the impact resistance containment interventions2. And all reports from WHO tell us about post antibiotics era that will be start if we don’t work quickly on antibiotics resistance by all efforts and due to situations of my country in Libya now need a lot of studies to decrease corruption in budgets put for health sector. Experimental methods: Study made by pilot method and we depend on data collected from dispensing papers of medical supply ward in Al Wahda hospital. *medical statistics office of Al Wahda hospital *Al Wahda hospital laboratory. *data collected to 3 months and 477 in- patient of wahda hospital. Results and discussion: After collect data from dispensing paper that based on treatment chart, we covered 477 patients for 3 months by 2169 ceftri-702 gent-1360 aug-547 cefot-23amik ...

Review Article of International Journal of Hospital Pharmacy PASS Protocol Fever as basis of COVID-19 testing in Patient- A Union Therapy Initiative Kanishk Kala, Rupinder Kaur Sodhi IK Gujral PTU Fever is the sole symptomatic measurement modality for Covid-19 screening which could be implemented easily all over the globe in with optimal utilization of resources. Being easy economical and easily reproducible, this has a potential to be a gold standard as well as simplicity of the procedure could help in its monitoring by patients itself and would operate an important element of patient involvement in treatment and would help in adherence in countries where health care staff are short and patient burden is high. This protocol will extend helping hands to health care worker and will involve patient participation in the treatment also. Keywords:COVID -19 , fever , Union Therapy , PASS protocol , Sayojya Chikitsa ...