International Research Journal of Diabetes and Metabolism


SYNTHETIC MOLECULES APPLIED IN THE TREATMENT OF TYPE 2 DIABETES

Review Article of International Research Journal of Diabetes and Metabolism Synthetic molecules applied in the treatment of type 2 diabetes João Alberto Lins de Lima1, 2, Rafael Artur Queiroz Cavalcanti de Sá3, Viviane Ramos Bandeira3, Francisco Henrique da Silva3, Matheus Alves Siqueira de Assunção4, Fálba Bernadete Ramos dos Anjos4, Bárbara de Azevedo Ramos2 1Departent of Chemistry, Rural Federal University of Pernambuco; 2Department of Antibiotics, Federal University of Pernambuco,  Recife, Pernambuco, Brazil; 3Department of Biochemistry, Federal University of Pernambuco,  Recife, Pernambuco, Brazil; 4Department of Histology and Embryology, Federal University of Pernambuco,  Recife, Pernambuco, Brazil Diabetes is considered a multifactorial disease that afflicts populations of the most diverse classes worldwide, being among the main health problems today. Among the types of diabetes, type 2 diabetes mellitus (DM-2) is considered the most prevalent pathology. This is due to the direct relationship between the cause of this disease and people’s eating behavior. These factors justify the growing search for the development of drugs for DM-2, given that current drugs act on targets that are not very efficient for the treatment. Therefore, the objective of this review is to evaluate the progress of research related to the search for new synthetic drugs for a more selective treatment for DM-2. The researches were searched in the main academic databases (National Center for Biotechnology Information (NCBI), Science Direct and Google Scholar), and research tools such as Drug Bank and Clinical Trials. Seventy articles were selected that were causally related to the descriptors used. According to the survey, about 60 compounds of synthetic origin were found and present in the various phases of the study and some molecules already approved for use. A variety of strategies and new therapies related to DM-2 grows each year, as new targets involved are elucidated. Therefore, it is possible to envision a ...

DIABETES CLASSIFICATION

Review Article of International Research Journal of Diabetes and Metabolism Diabetes classification Francisco Henrique da Silva1, Matheus Alves Siqueira de Assunção2, João Carlos de Oliveira Pinto1, Alamisne Gomes da Silva3, Aline Fernanda Carneiro Cardoso3, Fálba Bernadete Ramos dos Anjos2 1Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil 2Department of Histology and Embryology, Federal University of Pernambuco,Recife, Pernambuco, Brazil 3Pharmaceuticalpela Federal University of Pernambuco, Recife, Pernambuco, Brazil The therapeutic approach established for diabetes control varies according to its classification. Understanding the differences between each type is possible a complete and distinct treatment for the individual. This chapter will address the classification of diabetes types as well as their main differences. Keywords:  LADA, MODY, Other types of diabetes ...

ANALYSIS OF THE KNOWLEDGE FROM DIABETICS ABOUT SAFETY OF ADMINISTRATION, PACKAGING AND DISPOSAL OF INSULIN IN THE OUTPATIENT PHARMACY AT A PHILANTHROPIC HOSPITAL IN RECIFE, STATE OF PERNAMBUCO

Research Article of International Research Journal of Diabetes and Metabolism ANALYSIS OF THE KNOWLEDGE FROM DIABETICS ABOUT SAFETY OF ADMINISTRATION, PACKAGING AND DISPOSAL OF INSULIN IN THE OUTPATIENT PHARMACY AT A PHILANTHROPIC HOSPITAL IN RECIFE, STATE OF PERNAMBUCO Flávia Patrícia Morais de Medeiros1 *, Maria Nelly Sobreira de Carvalho Barreto2, Ítala Morgânia Farias da Nóbrega2, Jesse José da Silva3, Wellington Claudino da Silva4, e Dayana Maria da Silva4 1Farmacêutica – Coordenadora do Curso de Farmácia da Faculdade Pernambucana de Saúde (FPS), 2Tutora do Curso de Farmácia da FPS, 3Egresso do Curso de Farmácia da FPS e Estudante PIBIC-CNPq IMIP (2015-2016) e, 4Egresso do Curso de Farmácia da FPS Objective: In order to analysis some aspects about the knowledge from diabetics patients related to therapy with insulin it was performed an observational, descriptive and cross-sectional study in the outpatient pharmacy at a hospital in Recife. Methods: This study was between February and May 2016, and involved 60 diabetics patients that were interviewed by a semi-structured questionnaire. Results: Some positive results included: self-monitoring of blood glucose, handling and application method, however there was little knowledge about sharpener disposal. Conclusion: This study provided subsidies to identify some of the main user needs in order to guide orientations regarding the accomplishment of educational activities in the service. Keywords:  Diabetes Mellitus; Patient Safety; Insulin; Needles; Syringes ...

ANXIETY AND DEPRESSION IN DIABETICS: A COMPARATIVE ANALYSIS BY GENDER

Research Article of International Research Journal of Diabetes and Metabolism ANXIETY AND DEPRESSION IN DIABETICS: A COMPARATIVE ANALYSIS BY GENDER Mateus Nunes Macedo1*, Gabriela de Oliveira Teles2, Lucas Raphael Bento e Silva3, Vitor Alves Marques4, Márcia Verônica Ertel5, Ana Cristina Silva Rebelo6 1ICB-UFG, 2FEFD-UFG, 3FEFD-UFG, 4FEFD-UFG, 5ICB-UFG, 6ICB-UFG INTRODUCTION: Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and/or action. Studies indicate that type 2 Diabetes Mellitus is related to the increased prevalence of mental health problems, especially depression and anxiety. Diagnosis is associated with an approximately 27% increase on the risk of developing depression, when compared with undiagnosed cases. OBJECTIVES: The objective of this study was to evaluate the prevalence of anxiety and depression in diabetics patients, to compare and correlate these aspects between men and women. METHODOLOGY: Participants were recruited at the Mutirão Diabetes, na event promoted in 2018 by the Municipal Health Secretariat of Goiânia/GO. After this first contact, volunteers were invited through phone calls for a blood exams and interviews. Patients with age between 40 and 60 years of both sexes were selected for the study. Symptoms related to depression were assessed by the Beck Depression Inventory (BDI), which discriminates the presence or absence of depressive behaviour. Anxiety was assessed by the State-Trait Anxiety Inventory (IDATE), which assesses symptoms related to anxiety. Blood glucose was measured and the adopted reference value was ≤99 mg/dL. Mean tests, standard deviation, Student’s t-test and Mann-Whitney tests were performed to compare means between groups and Pearson and Spearman bivariate correlation. RESULTS: The sample consisted of 96 individuals, with a mean age of 56.2 ± 9.6 years, 55.3% female and 42.7% male, and with a mean time of disease (diabetes) of 10.0 ± 7.6 years. The results showed that most of the subjects ...

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Open Access

International Research Journal of Diabetes and Metabolism (ISSN:2637-6717;10.28933/IRJDM) is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Diabetes and Metabolism.

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International Research Journal of Diabetes and Metabolism

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