Journal of Herbal Medicine Research


Hydroethanolic extract of Theobroma cacao beans is non toxic and attenuates oxydative stress induced by Naphtalene in Wistar rats

Research Article of Journal of Herbal Medicine Research Hydroethanolic extract of Theobroma cacao beans is non toxic and attenuates oxydative stress induced by Naphtalene in Wistar rats Feudjio A.F.1, Biapa N.P.1,2*, Kodjio. N3,Yembeau N.L.1, Kengne F.C.1, Nkwikeu N.P.1, Pieme C.A.2 Telefo P.B.1 1Research Unit of Medicinal Plant Biochemistry, Food Science and Nutrition, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67 Dschang - Cameroon. 2Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I – Cameroon, P.O. Box 1364 Yaoundé–Cameroon. 3Research Unit of Microbiology Research and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67 Dschang - Cameroon. Background: Oxidative stress is a situation where the cell no longer controls the excessive presence of toxic oxygen radicals. Many human diseases have a strong relationship with oxidative stress due to an imbalance between antioxidants and pro-oxidants. The objective of this study is to evaluate the in vivo antioxidant capacity of Theobroma cacao (T.cacao) beans extract and its acute toxicity. Methods: T. cacao beans were collected in the Obala locality (Center Cameroon) and then subjected to hydroethanolic extraction (70:30) at pH 3. The in vivo oxidative stress induction was done using naphthalene at 110 mg / kg and different doses of extracts (50 mg / kg, 100 mg / kg, and 200 mg / kg) were orally administered to rats. Some oxidative stress parameters helped to evaluate the antioxidant potential of the extract (superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA)). In addition, the acute toxicity of T. cacao was evaluated by the methods recommended by the ODCE. Test groups received respectively the extract at different doses (5000 mg / kg and 2000 mg / kg) against 10% of DMSO and distilled water as neutral controls ...

Anti-bacterial Activity of Aqueous and Methanolic Root Extracts of Medicinal Plant Heteropogon contortus

Research Article of Journal of Herbal Medicine Research Anti-bacterial Activity of Aqueous and Methanolic Root Extracts of Medicinal Plant Heteropogon contortus Ruvani Gamagea, Buddhika Hasanthia,*, Rajith Silvab, Daya Ratnasooriyab, Ranjith Pathiranab, Sujeewa Hettihewac, a National Science Foundation, Maitland Place, Colombo 7, Sri Lanka; b Department of Basic Sciences, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University, Werahera, Sri Lanka; cDepartment of Pharmacy, Faculty of Medicine, University of Ruhuna, Karapitiya, Sri Lanka Synthetic drugs available for the treatment of chronic and infectious diseases are very expensive and some of them have become less effective due to the emergence of antibiotic resistance. Researchers are now focused on natural sources including plants and plant parts for the development of novel therapeutic agents. Therefore, this study evaluated in vitro anti-bacterial activity and phytochemical composition of aqueous and methanolic root extracts of Sri Lankan medicinal plant Heteropogon contortus against clinically significant pathogens, Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923). Agar well diffusion method and standard chemical tests were performed to evaluate anti-bacterial effect and phytochemical profile of the root extracts, respectively. The results revealed that each crude root extract exhibited anti-bacterial activity against both E. coli and S. aureus. The largest zones of inhibition against both E. coli and S. aureus were detected from the methanolic root extract at a concentration of 200 mg/mL and this is a novel finding. Phytochemical analysis of roots revealed the presence of bioactive constituents that account for the anti-bacterial potential, such as alkaloids, phenols and flavonoids. Thereby, root of H. contortus is a reliable source to develop potent, cheap and natural anti-bacterial agents. Future research focusing on high concentrations of different root extracts is recommended to further understand the anti-bacterial capability of H. contortus. Keywords: Heteropogon contortus, medicinal plant, root, anti-bacterial activity ...

ANTITUMOR ACTIVITY of EXTRACTS of Caulerpa taxifolia in the SARCOMA 180 TUMOR TREATMENT

Research Article of Journal of Herbal Medicine Research ANTITUMOR ACTIVITY of EXTRACTS of Caulerpa taxifolia in the SARCOMA 180 TUMOR TREATMENT Evandro Valentim da Silva1,2, Livia Nara Eugênio Pereira², Gabriela Cavalcante da Silva²; José Ferreira Silva Neto3, George Chaves Jimenez3, Fálba Bernadete Ramos dos Anjos1, Ivone Antonia de Souza2 1Department of Hstology and Embryology Universidad Federal of Pernambuco, Brazil; 2Department of Antibiotics Universidad Federal of Pernambuco, Brazil; 3Fisiology and Pharmacology Animal of Universidad Federal Rural of Pernambuco, Brazil; Cancer is a disease characterized by the multiplication and spread out of control in the form of anomalous cells. A normal cell becomes cancerous cells as a result of one or more mutations of DNA. Marine algae are a rich source of bioactive compounds, some of which are precursors of pharmacological tools and potentially useful substances for the development of new drugs. The present study aims to evaluate the antitumor activity of Caulerpa taxifolia front of Sarcoma 180 in albino mice (Mus musculus). The transplanted animals with sarcoma 180 (n = 24), were divided into four groups (n = 6) treated with two extracts: the MeOH extract (T1) and from hydroalcoholic C. taxifolia (T2) at a dose of 50 mg/kg ip. The control group (S1) received saline for the same route of administration. The default group (S2) received the reference drug to the tumor lineage. The data revealed that the S3 and S4 group responded to treatment with reduction of 63.6 and 42, 0 % respectively, as compared to EN/PA, when compared with the control group. The activities of extracts were higher than those of the reference drug for the Sarcoma 180. Keywords:phytotherapy, bioassay, bioactivity ...

Secondary Metabolism and Therapeutic Efficacy of Medicinal Plants

Review Article of Journal of Herbal Medicine Research Secondary Metabolism and Therapeutic Efficacy of Medicinal Plants AK MOHIUDDIN Faculty of Pharmacy, World University of Bangladesh Medicinal plants constitute main resource base of almost all the traditional healthcare systems. Most of the herbal drugs produced currently in majority of the developing countries lack proper quality specification and standards. Herbal drugs used in traditional medicine may contain a single herb or combinations of several different herbs believed to have complementary and/or synergistic effects. Both the raw drugs and the finished herbal products manufactured contain complex mixtures of organic compounds, such as fatty acids, sterols, alkaloids, flavonoids, polyphenols, glycosides, saponins, tannins, terpenes etc. The quality of the finished product is based on the quality of the raw materials. As many as 35% of the medicinal plants used in Indian systems of medicine are highly cross pollinated which indicate the existence of a wide range of genetic variability in the populations of these medicinal plant species which in turn reflected in the variations in the composition of secondary metabolites. Ecological and edaphic as well as seasonal variations also cause changes in the chemical composition of medicinal plants. These facts have to be considered while developing quality parameters! standards of medicinal plants and their finished products.Purpose of the study: An illustrated review of factors that influence secondary metabolism of plants and their impacts on therapeutic efficacy.Findings: Traditional plants are used from ancient time for various human well-being, both as life-saving and lifestyle drugs. A careful observation may explore facts behind therapeutic efficacy of these plants.Materials and Methods: A comprehensive literature review, consulting books, technical newsletters, herb magazines, journals, and many other sources. Health professionals like qualified doctors, herbal specialists, folk healers, alternative medicine specialists given their valuable suggestions. Research limitations: The limitation lies with the ...

Editor-in-chief: 

Dr. Juei-Tang Cheng 
 Chair-Professor, Institute of Medical Research, Chang Jung Christian University, Taiwan.

Editors

Dr.  George Perry
Dean and Professor of Biology and Chemistry and Semmes Foundation Distinguished University Chair in Neurobiology, College of Sciences, University of Texas at San Antonio, USA.

Dr. Abimbola Farinde
Professor, Columbia Southern University, Orange Beach, AL, USA.

Dr. Gianni Sacchetti 
Professor, Department of Life Sciences and Biotechnology, Corso Ercole I d’Este 32, 44121 Ferrara, Italy.

Dr. Pongsak Rattanachaikunsopon
Professor, Department of Biological Science, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.

Dr. Atanas Pavlov
Professor, Department Industrial Microbiology, Laboratory of Applied Biotechnologies, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Bulgaria.

Dr. Parveen Bansal
Joint Director, University Centre of Excellence in Research, Baba Farid University of Health Sciences, Faridkot-151203 (Punjab), India.

Dr. Peter A. Akah
Professor, Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria.

Dr. Petropoulos Spyridon
Department of Agriculture, Crop Production and Rural Environment, School of Agricultural Sciences, University of Thessaly, Magnissia, Greece.

Dr.Rabin Chandra Paramanik
AL-Falah Group of Institutions, behind kalya Gate, Ramanagara District, Magadi - 562120, Karnataka, India.

Dr. Snehangsu Sinha
College of Veterinary Science, AAU, Guwahati, Assam

Dr. Bajpayee Kaptain Kishor
Assistant Professor &HOD in the Botany Department, DR.RML P.G. COLLEGE (C.S.J.M. UNIVERSITY), HARDOI 241001 INDIA.

Dr. Sidharth Mehan
Associate Professor, Department Of Pharmacology, Rajendra Institute Of Technology & Sciences (Rits), Doping Control Officer (Nada), Ministory Of Youth Affairs And Sports, Government Of India.

Dr. Manisha H.Vite.
Associate Professor, Shivajirao Jondhle college of pharmacy, Asangaon, Mumbai.

Dr. Mayuri C. Rathod

Assistant Professor, Biotechnology Department, C.R.C. Building, Veer  Narmad  South Gujarat university,

Dr Ranjeet Satyawan Sawant
Assistant Professor, Dept. of Rasashastra & BK, KGMP Ayurvedic Mahavidyalaya, Charni Road, Mumbai.

Dr Jiban Shrestha
Scientist (Plant Breeding & Genetics), Nepal Agricultural Research Council, National Maize Research Program, Rampur, Chitwan, Nepal

Dr. K.S. Kanwal
Scientist-C, G.B. Pant National Institute of Himalayan Environment and Sustainable Development, North East Unit, Vivek Vihar, Itanagar-791113, Arunachal Pradesh, India

Dr. Swapnil Sabgonda Patil
Assistant Professor of Dept. of Rognidan Avum Vikrutividnyan and Working as a Pathologist in Dhanwantari Hospital, Ashta, Dist. Sangli.

Dr. Rozbeh Farhoudi
Head, Department of Agronomy and Plant Breeding, College of Agriculture, Islamic Azad University, Shoshtar Branch, Shoshtar, Iran.

Dr. Ayub Khan
Chairman & Professor, Department of Agricultural Sciences, University of Haripur, Khyber Pakhtunkhwa, Pakistan.

Dr. Muhammad Hamayun 
Associate Professor & Chairman, Department of Botany, Abdul Wali Khan University Mardan (AWKUM), Khyber Pakhtunkhwa, Pakistan.

Dr. Amit R. Nampalliwar
Assistant Professor, Smt. K.G. Mittal Ayurved Medical College & Hospital, N.S. Road, Charni Road Station(West), MUMBAI-400002, India.

Dr. Fahmy Abd El-Rahman Sadek Hassan

Professor of Medicinal & Ornamental plants, Faculty of Agriculture, Tanta University, Egypt.

Dr. Kaptain Kishor Bajpayee
Assistant Professor & Head Deptt. of botany, Dr. RML degree college (C.S.J.M. University), Hardoi up241001, india.

Dr. Majid Sharifi-Rad
Department of Range and Watershed Management, Faculty of Natural Resources, University of Zabol,  Iran.

Dr. Devendra Kumar Patel
Assistant Professor, Rural Technology Department, Guru Ghasidas Vishwavidyalaya, (A Central University), Bilaspur (Chhattisgarh), India.

Dr.  Shyamapada Mandal
Associate Professor and Head, Department of Zoology, Laboratory of Microbiology and Experimental Medicine, University of Gour Banga, Malda-732 103, India

Dr. Abhishek J. Joshi
Chair of Ayurveda, Fakultas Ayurweda, Universitas Hindu Indonesia(UNHI), Denpasar, Bali, Republic of Indonesia.

Dr.  Datta Asaram Dhale
Assistant Professor, Post-Graduate Department of Botany, S.S.V.P.S.’S, L.K. Dr. P. R. Ghogrey Science College, Dhule, Maharashtra, India.

Dr. Ravi Shankar khatri
Assistant professor, Dep’t of Kaumarbhritya, A & U Tibbia College and hospital, karol bagh, India.

Dr. Shahin Gavanji
Chairman of “WAMS National Council of Iran at World Academy of Medical Sciences (WAMS), Chairman WAMS Oncology Research Group of Iran, Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Khorasgan, Isfahan, Iran, Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.

Dr. Munesh Kumar
Assistant Professor, Department of Forestry, HNB Garhwal University, Srinagar Garhwal, Uttarakhand-249161, India

Dr. Shicheng Guo
Department of Bioengineering, The University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA, USA.

Dr. Mario Bernardo-Filho
Professor Titular, Universidade do Estado do Rio de Janeiro

Dr. Parichat Phumkhachorn
Assistant Professor, Faculty of Science, Ubon Ratchathani University

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1. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Journal of Herbal Medicine Research is a peer reviewed open access journal publishing research manuscripts, review articles, case reports, editorials, letters to the editor in Herbal Medicine (indexing details).

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