Journal of Herbal Medicine Research

Use of medicinal plants in the diabetes treatment

Review Article of Journal of Herbal Medicine Research Use of medicinal plants in the diabetes treatment Aparecido Jonanthan Mandú de Araújo1,2, Amanda Virgínia Barbosa2, Francisco Henrique da Silva1, Rafael Artur Queiroz Cavalcanti de Sá2, Sivoneide Maria da Silva2, Bárbara de Azevedo Ramos3, Matheus Alves Siqueira de Assunção4, Márcia Vanuza da Silva1, Maria Tereza dos Santos Correia1 1Department of Pharmacy, Federal University of Pernambuco, Recife, Pernambuco, Brazil 2Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil 3Department of Antibiotics, Federal University of Pernambuco,  Recife, Pernambuco, Brazil 4Department of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil Medicinal plants have been used by the population since the beginning as a tool to prevent and fight diseases. In addition, to strengthening local culture and offering cheaper labor, this practice is an alternative to conventional therapies. The use of these plants in metabolic disorders has been studied worldwide. It has shown promising results in reducing glycemic levels and profiles related to diabetes, such as LDL lipid profile, total cholesterol, triglycerides, and glycated hemoglobin (HbA1c). These results can be potential sources for pharmacological treatments, through the production of medicines, as well as the implementation of these plants in the diet, dispensing with the use of commercialized drugs. Keywords: Phytotherapy, diabetes, dyslipidemia ...

Local Understanding of Microbial Infections and the Implication on Care of Coronavirus and Disease

Research Article of Journal of Herbal Medicine Research Local Understanding of Microbial Infections and the Implication on Care of Coronavirus and Disease Aderemi Suleiman Ajala, Kayode Akinsete, Idayat T. Gbadamosi, Sam.K, Olaleye University of Ibadan Local categorization of illness and disease can form insight on the understanding of people’s behaviour and attitudes towards microbial infections and how such implicates Coronavirus and disease COVID-19. Relying on data generated through rapid research approach in some Yorùbá cities of southwestern Nigeria, where phoning, WhatsApp, Facebook, quick in-depth interviews, ethnobotanical survey/analysis of some anti-microbial herbs and case analysis were held. The study reveals local understanding of microbial infection and the opposing and contrasting perceptions of COVID-19, which informs different regimes of care and prevention. Such includes non-categorization of microbial infections into viral, bacterial and fungi; biomedical against preternatural causation and utilization of local herbs versus globalised western health care strategies. The study therefore suggests that within the context of globalised health culture accommodation of local traditions is imperative in proper understanding and invention of care and preventive strategies against COVID-19. Keywords: COVID-19; Yorùbá of southwest Nigeria; Local perception; globalised health behaviours; biomedical and preternatural causation ...

Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans

Research Article of Journal of Herbal Medicine Research Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans María Dolores Jimenez1, Laura López-Ríos2*, Rubén Pérez-Machín2, Ricardo Chirino3, Barbara Davis4, Elena Talero1#, Virginia Motilva1# 1Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain; 2Nektium Pharma SL, Las Palmas, Spain; 3Department of Biochemistry, Molecular Biology and Physiology, Faculty of Health Science, University of Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain; 4PLT Health Solutions, Inc., Morristown, New Jersey, USA Xanthigen® is a nutraceutical combination of two well-known natural products, brown seaweed extract (rich in fucoxanthin) and pomegranate seed oil (rich in punicic acid), and it has been designed to use in weight management, in conjunction with a calorie restricted diet. In the nematode Caenorhabditis elegans Xanthigen® treatment caused a significant reduction in lipid deposition in wild-type N2 (WT-N2) animals but not in sirt-2.1-deficient strain, which raises the possibility that the prolipolytic or anti-lipogenic effect of Xanthigen® in these animals is mediated through Sirtuin 2.1 activation. This response has been well described for Xanthigen® in cell cultures and other animal models. In addition, Xanthigen® treatment conferred to both strains an increased resistance to thermal and oxidative stress, which opens the possibility that the effects of Xanthigen® are not mediated solely by Sirtuin 2.1 activation. We therefore explored whether Xanthigen® could activate diverse defence mechanisms such as DAF-16 activation, or GST induction in response to xenobiotics, by using the strains TJ356, CL2070 and CL2166, stably expressing Pdaf-16::GFP, Phsp-16.2::GFP and Pgst-4::GFP, respectively. Xanthigen® treatment provoked neither DAF-16 translocation to the nucleus nor increased expression of HSP16.2 and GST4, which opens the possibility that different mechanisms other than DAF-16 and those involved in xenobiotic responses, are activated by Xanthigen® and are capable of conferring to the nematode an increased resistance to thermal ...


Research Article of Journal of Herbal Medicine Research CLINICAL STUDY OF SAHADEVI (Vernonia cineria Less.) KSHARA IN PERSPECTIVE OF GRANTHI W.S.R. CANCER Vimla Kumari1 and Kamini Kaushal2 1PG Department of Dravyaguna, UAC, Dehradun. 2H.O.D., PG Department of Dravyaguna, MMM Govt. Ayurved College, Udaipur (Raj) INTRODUCTION-Cancer’ is not directly mentioned in Ayurvedic text as one disease. Many diseases, which are described in Ayurvedic text, show similarities with Cancer. Also etiology (Nidan), pathogenesis (Samprapti), treatment(Chikitsa) of cancer can be described by considering the basic principles of Ayurved. Granthi is a term for a tumour, lump or nodule. Granthi may be benign or malignant. In Ayurvedic literature, a detailed description is given of various types of tumors. Terms such as gulma, granthi, utseda and arbuda are used for specific tumor conditions. AIMS & OBJECTIVES-1.Conceptual and clinical studies on Granthi. 2.To evaluate safety and efficacy of Sahadevi Panchang Kshara in management of Granthi. MATERIALS & METHODS-The study was conducted on 30 clinically diagnosed and confirmed patients of Granthi from OPD/IPD of Rajvaidhya Premshankar Sharma Govt. Ayurvedic Hospital, Udaipur. Group A- 15 Patients of simple granthi (Benign tumour) were treated by 500mg capsule Sahadevi kshara two times a day with normal water for 60 days. Group B- 15 Patients of malignant granthi were treated by 500mg capsule Sahadevi kshara two times a day with normal water for 60 days. The patients will be diagnosed with the help of various subjective parameters. RESULT-Pain, tenderness, fatigue, size of lump symptoms were significant In Group A and Pain, Tenderness, Size of lump, Nausea, fatigue,, Constipation, Gas in Abdomen, Heaviness in Chest symptoms were significant in group B. Pain was improved in both groups. CONCLUSION-Sahadevi Kshara proved to be an effective, safe, promising and cost effective in the management of cancer. Keywords: Granthi, cancer, sahadevi kshara, malignant ...

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