Journal of Pharmaceutical Research and Reviews


Review Article of Journal of Pharmaceutical Research and Reviews PAST, PRESENT AND FUTURE OF REMDESIVIR—OVERVIEW OF A MOST POPULAR ANTIVIRAL IN RECENT TIMES DWAIPAYAN SARATHI CHAKRABORTY*, SHOUVIK CHOUDHURY REGISTRAR, DEPARTMENT OF CARDIOLOGY, BELLE VUE CLINIC Recent international epidemics of coronavirus-associated illnesses underscore the urgent medical and public health need for vaccine development and regulatory body approved therapies. In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human life. Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. Currently available evidence about the antiviral effects of remdesivir against to accumulate before the clinical trials are concluded. It is imperative for public health practitioners and the One Health community to stay up to date on the most promising potential therapeutic options that are under investigation. Thus, the purpose of this review is to synthesize the knowledge to date about remdesivir as a therapeutic option for coronaviruses, with a special focus on information relevant to the One Health community Keywords: REMDESIVIR, COVID-19, Review ...

Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats

Research Article of Journal of Pharmaceutical Research and Reviews Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats Odinga, T.1,2, Nwaokezi, C.O.1 1Department of Biochemistry, Rivers state university. Nigeria; 2Department of Biochemistry, University of Port Harcourt, Rivers state, Nigeria. This study evaluated the potentials of the seed extract of Ricinodendron heudelotii on the oxidative stress biomarkers of diabetic albino rats of the wistar strain. Diabetes mellitus was induced via intraperitoneal administration of 160 mg/ kg bodyweight Alloxan monohydrate in normal saline and confirmed after 120 hours of blood glucose level above 300mg/dl. Blood samples were collected from the animals and analyzed for Malondialdehyde, Catalase, Reduced Glutathione, Glutathione-S-transferase, Glutathione peroxidase, and Superoxide dismutase activities as biomarkers of oxidative stress. The result revealed a significant decrease at P≤0.05 in blood glucose concentration of diabetic rats with increase in the seed extract concentration, Malondialdehyde (MDA) decreased significantly in the diabetic rats while Catalase increased significantly at P≤0.05 as the extract concentration increased. Variations in Glutathione-S-transferase, Glutathione Peroxidase, Superoxide dismutase and Reduced Glutathione in comparison with control was observed.  The results therefore suggests that the aqueous seed extract of Ricinodendron heudelotii has the potency to reduce glucose level and act as antioxidants against oxidative stress, hence its use therapeutically. Keywords: Ricinodendron heudelotii, Alloxan monohydrate, Antioxidant biomarkers, Diabetes mellitus, oxidative stress ...

Different Methodology for Preparation of NLCs – A Review

Review Article of Journal of Pharmaceutical Research and Reviews Different Methodology for Preparation of NLCs - A Review R.C.Doijad , S.V.Salve, Patil Anup KIMSDTU's Krishna Institute of Pharmacy, Karad, Maharashtra, India Nanotechnology in the formulation developed exponentially, the main objective or the basic aim has been on therapeutic undertaking, particularly for targetted drug therapy. Nanocarriers are at forefront of the rapidly developing field of nanotechnology with several potential applications in novel drug delivery, also in clinical medicines and research. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in medicinal formulation and other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutic effect. The incorporation of drugs into nanocarriers offers a new prototype in drug delivery that could be used for different levels of drug targeting. Nanostructure lipid carriers have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceutical consignment. Today’s new generation of nanostructured lipid carriers (NLCs) consisting of a lipid matrix with a special nanostructured has been developed. This nanostructure improves drug loading and firmly incorporates the drug during storage. The present review gives insights on the definitions and different techniques of preparation of NLCs. Keywords: Nanotechnology, Solid lipid nanoparticles, Nanocarriers, nanostructured lipid carriers, novel drug delivery ...

Progress in the application of LOV2 domain in protein interaction

Review Article of Journal of Pharmaceutical Research and Reviews Progress in the application of LOV2 domain in protein interaction Xiao Shao College of Medical , China Three Gorges University, Yichang, 443002, China. Protein-protein interactions (PPIs) and protein complexes formed by interactions are the main accomplishers of various functions of cells. As an important component of biological networks, protein interaction plays an important role in determining life processes such as signal transduction in cells. Although the experimental methods for studying protein interactions are endless, there are still many shortcomings and gaps in the research on the interaction of precisely regulated protein molecules. LOV (Light Oxygen Voltage) is a light-sensitive protein domain originally discovered in the photo of plants for receiving blue light stimulation, transmitting signals, and causing a series of reactions in plants. The LOV domain belongs to a member of the PAS (Per-Arnt-Sim) superfamily and contains two subunits, LOV1 and LOV2. LOV2 is thought to cause a conformational change after receiving light stimulation, primarily responsible for activating the kinase domain. It plays an important role in intracellular signal transduction. In view of the light control and sensitivity of LOV2, which can be used as a research tool in protein interaction processes, the mechanism of action and structural advantages of signal transduction in LOV2 domain in protein interactions are reviewed. Keywords: Protein interaction; LOV2 domain; Optogenetics; Light-sensitive protein; Photon ...

Dr. Rakesh Kumar Dixit
Professor, Department of Pharmacology & Therapeutics, King George’s Medical University Lucknow

Dr. Mahavir Chhajed
M. Pharm. (Pharm. Chemistry), Associate Professor

Dr Yusra Habib Khan
University Sains Malaysia

Dr. Tauqeer Hussain Mallhi
School Of Pharmaceutical Sciences, Usm, Penang, Malaysia

Lecturer in Pharmacy, Department of Basic Medical Sciences, Faculty of Pharmacy, Hajvery University

Dr Viraj H Mankar
Assistant Professor, Lovely Professional University

Dr. Dhananjay Kumar Singh
Molecular Bio-prospection Department, CSIR-CIMAP

Dr. Theophine Akunne 
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria

Dr Yassine MAHDI
Laboratory of Pharmaceutical Engineering, University of Sciences and Technology Houari Boumediene

Dr. Hamzah Maswadeh
Associate Prof. Head of Department of Pharmaceutics, College of Pharmacy – Qassim University -KSA

Dr. Vandna Kukshal
Department of Internal medicine, Washington University School of Medicine

M Nurul Amin
Department of Pharmacy, Atish Dipankar University of Science and Technology

Dr. Marwa A. Fouad
Associate Professor, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Journal of Pharmaceutical Research and Reviews is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Pharmaceutical Research (indexing details).

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Journal of Pharmaceutical Research and Reviews