American Journal of Histology and Cytology


Case Report of American Journal of Histology and Cytology  “Two in One”- A rare case of neoplastic collision tumor Vanessa Fonseca-Ferrer*, MD; Alba Rivera-Diaz, MD; Luis-Gerena-Montano, MD; Christian Castillo-Latorre MD; Sulimar Morales-Colon, MD;Andres Velazquez-Garcia, MD; William Rodriguez-Cintron, MD. “Pulmonary and Critical Care Fellowship Program” VA Caribbean Health care System, San Juan, Puerto Rico. Collision tumors are a rare group of tumoral pathologies characterized by their composition, which is based by the presence of two or more tumor types affecting the same anatomical site and separated by distinct tumor borders. These tumors may be a combination of either malignant or benign tumors [1]. Collision tumors are classified as independently coexisting neoplasms which have different genetic, behavioral, and histological features separated by a distinct demarcated border but coexist within the same organ [2]. These tumors tend to have distant immunohistochemical and morphological differences which aid in diagnosis, but can lead to confounding imaging findings, which in times, make diagnosis more challenging. According to literature this tumor tends to grow simultaneously or following each other in sequence of less than 2 months apart [3]. Accurate classification and diagnosis of these tumors is important for proper treatment options, as well as better patient outcomes. Here will be discussed a case of a rare form of collision tumor, compose of a primary lung adenocarcinoma with a mucosa-associated lymphoid tissue (MALT) lymphoma. Keywords: Collision tumor, lung adenocarcinoma, lymphoma, combined tumor ...


Case Report of American Journal of Histology and Cytology Pathological Approach to Pleural Malignant Mesothelioma Vanessa Fonseca-Ferrer, MD; Luis Gerena-Montano, MD , Héctor A. Nieves Figueroa, MD; William Rodriguez-Cintrón, MD VA Caribbean Healthcare System, San Juan P.R; Pulmonary and Critical Care Medicine Exposure to asbestos can lead to asbestosis or malignancy 10-40 years after initial exposure [1]. Although its use has been banned in multiple countries, past occupational exposure leads to most cases that we see in present time.  Malignant mesothelioma is an insidious and rare neoplasm that can arise from mesothelial surface cells, being Malignant Pleural Mesothelioma (MPM) the most common type. Lifetime risk of developing mesothelioma among asbestos workers can be as high as 10 percent and latency period is approximately 30-40 years since time of exposure to development of disease [2]. Annual incidence in the united states is approximately 3,300 cases per year [3]. Median overall survival of patients with advanced unresectable disease is approximately 12 months [4]. Clinical suspicion should arise in patients with previous exposure to asbestos who present with pleural thickening and/or effusion with associated respiratory symptoms. Most symptoms are nonspecific such as chest pain, dyspnea, cough and night sweats. Initial evaluation includes chest x-ray, contrast enhanced CT of the chest to find pleural abnormalities, thoracentesis and closed pleural biopsy. However, difficulties establishing diagnosis have been illustrated on studies where thoracentesis and pleural fluid cytology only yields diagnosis in 26% of cases. The diagnosis, then, is established by morphologic and immunohistochemistry findings of cytologic and surgical specimens. Keywords: Pathological Approach; Pleural Malignant Mesothelioma ...


Research Article of American Journal of Histology and Cytology Pathological Changes In The Rats’ Eyes After The Administration Of Oil Machinery Fluid Through Stereotaxic Surgery Martha Lilia Tena-Suck1*, Alma Ortiz-Plata2, Joaquín Manjarrez3, Wilhelm Moreno4, Carmen Rubio4 , Francisca Fernández-Valverde2 1Instituto Nacional de Neurología y Neurocirugía. Departamento de Neuropatología. Ciudad de México. 2Instituto Nacional de Neurología y Neurocirugía. Laboratorio de Neuropatología experimental Ciudad de México. 3Instituto Nacional de Neurología y Neurocirugía. Laboratorio de formación Reticular. Ciudad de México. 4Instituto Nacional de Neurología y Neurocirugía.  Departamento de Neurofisiología Ciudad de México. Purpose: To achieve a relationship between oil machinery fluid (OMF) and the damage this fluid produces in several eye structures. In neuro-oncology patients, we know there are several parasellar tumors; one of them is the craniopharyngiomas that can produce a cystic structure containing an oily material. It has been denominated as an oil machinery fluid (OMF); this fluid has not yet been widely studied. It is a widely held view that it produces toxic effects in the brain and other structures. This paper aims to see the toxicity of the OMF when administered directly in the brain and the changes produced in the rats’ eyes. Methods: 30 Wistar rats were divided into three groups, control, sham and experimental; the oil machinery fluid was obtained directly from human patients during surgery. The oil machinery fluid was administered to the rat thalamus by stereotaxic surgery. The subjects were under observation after the surgery for five weeks and sacrificed once the observation period ended. Finally, immunohistochemistry was performed on tissue recovered from the eyes. Results: We observed that in the experimental group, there was an increase in glucose levels, the coloration of the eyes changed to a pinkish color, the lenses changed opacity, there were histological changes in the retina, and a reduction of ...


Research Article of American Journal of Histology and Cytology Expression of transcription factors (STAT 2, 3, 4, and 6, HDAC1, HDAC2) in craniopharyngioma Martha Lilia Tena-Suck. M.D.1*, Wilhem Moreno. M.D.2, Sergio Zavala-Vega. PhD3 , Carmen Rubio. PhD4* 1Departamento de Neuropatología. Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez. Ciudad de México. 2Laboratorio de Neurofisiología. Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez. Ciudad de México. México. 3Department of Neuropathology. National Institute of Neurology and Neurosurgery. México City, México. 4Laboratorio de Neurofisiología.  Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez.  Ciudad de México. Background: Craniopharyngioma is a benign tumor of the sellar region that is typically characterized by a maldevelopment tumor with a high recurrence rate, as well as substantial morbidity and mortality in the long term. Signal transducers and transcription activators have been identified as critical components of cytokine signaling pathways that have previously been documented in craniopharyngioma-related literature. Purpose: The primary goal of this investigation is to examine transcription factor expression in craniopharyngiomas. In addition, a clinical-pathological and immunohistochemistry correlation will be sought. The current study enlisted the participation of forty patients. AdaCPs exhibited: β-catenin STAT2, STAT3, STAT6, and HDAC1 expression. While, STAT4, HDAC2, and GATA 3 were all negative. TTF1 was found in proteinaceous substances within the cyst formation (OMF). β-FGR, DPGR, TNFa, and Nrf2 were found to be associated with inflammation, OMF presence, and finger protrusion in brain surrounding tissue or brain invasion. Conclusions: Tumor recurrence was associated with increased expression of STAT3, STAT6, HDAC, β-catenin, and TNFα in WLA when compared to no recurrence. Coexpression of β-catenin, STAT2, STAT3, and STAT6 with TNFα was also shown using double fluorescence merge stains. There was no association between HDAC1 and HDAC2 coexpression and β-catenin, notably in the WLAs. Discussion: Histologically complicated features include cystic and ...

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American Journal of Histology and Cytology1