Toxicity of Indigenous plant Ambrosia maritima was investigated. Twenty fore, 6-8 month old, 12 female and 12 male of Sudanese Nubian goats were used. Dried Leaves powder of Ambrosia maritima was mixed with water and given orally by drench to the animals at a dose of 1000 or 2000mg/kg/day for 126 days. Two females drenched the plant at a dose of 1000mg/kg/day, were died at day 8 and 9 post treatment and one female drenched the plant at a dose of 2000/kg/day died at day 13. The results revealed that goats drenched the plant for 126 days, showed chronic toxicity evident by clinical symptoms, pathological and biochemical changes. The main symptoms were watery diarrhea, inappetance, respiratory distress and depression. Later these symptoms disappeared and the animals appeared healthy. The most evident pathological features were hydrothorax, hydropretonium, hydropericardium, and enlargement of the liver. Histopathological changes were exemplified by degeneration and necrosis of the hepatic cells. Focal necrosis, congestion and haemorrhag of proximal convoluted tubules. Necrosis of intestinal vili with severe infelteration of inflammatory cells. Congestion of alveolar capillaries and pancreatic hyperplasia. These changes were correlated to the activity of Asparate Aminotransferase (AST), Alkaline phosphate (ALP), the concentration of cholesterol, sodium and potassium in the serum, and with the hematological values. The effect of the plant on males was less marked compared to that on female goats. There was gradual increase in mean body-weight of both sexes.