Recent Articles

Concern has been expressed worldwide about the rising prevalence of HCV induced acute hepatitis and chronic liver diseases with associated cirrhosis and liver cancers. However, the available synthetic drugs are ineffective for all the HCV genotypes especially in genotype-1 patients with about 40% viral response rates and numerous side effects. Besides, the availability of veritable bioinformatics tools which includes molecular docking and virtual screening studies have shown that computational generated models nowadays assists in modern drug design and development of novel and more potent inhibitors through the understanding of protein (receptors) -ligand (drugs) interaction mechanisms. Non-structural proteins especially the 5B (NS5B) is an RNA-dependent RNA polymerase implicated in the synthesis and replication of the HCV RNA; and has been a potential target for its inhibitory activities. Due to the paucity of knowledge, we aimed to determine the differential inhibitory activity of essential oils present in the crude Sesame leaves extracts on HCV-NS5B RNA dependent RNA polymerase. Using in-silico studies- a Microsoft pharmacophore-based virtual screening and molecular docking tools on the iGEMDOCK vs 2.0 software was used to dock the essential oil ligands on the generated HCV NS5B (PDB ID: 4EO6) RNA-dependent RNA polymerase protein. GC-MS of the leaves confirmed carboxylic acids and phenolic groups in the essential oils especially some potent antioxidants like alpha-linolenic acid, linoleic acid, oleic acid, etc. Moreover, Alpha-Linolenic acid/ALA (-102.2/-103.4 kcal/mol) and Linoleic acid/LA (-94.8/-109.8 kcal/mol) showed higher inhibitory impacts among the six top different docked ligands, selected based on their high differential binding affinity and pharmacological interaction energy profiles against HCV NS5B RNA polymerase activities, by forming more H-bond interactions than the NS5B co-crystallized ligand. ADMET showed that ALA is well tolerated without any apparent toxicity in the body. Hence, ALA having the highest inhibitory impacts against the HCV NS5B goes to confirm the beneficial…

Posterior Reversible Encephalopathy Syndrome (PRES) is a clinico-radiographic syndrome characterized clinically by new onset neurological manifestations as well as neuroimaging findings of reversible cerebral edema. We report a case of PRES in the setting of systemic lupus erythematosus (SLE) with new-onset Class IV Nephritis treated with pulse corticosteroids, plasma exchange, intravenous immunoglobulin (IVIG) and cyclophosphamide. We also present a brief review of the associations between PRES and SLE.

In this study the effect of four treatments of phosphate fertilizers (NS, RP, SP & RP inoculated with PSF (A. niger & A. fumigatus) using three doses (RD, 1/2 RD&2RD) on TN, OC and MC of Nile delta clay soil and its impact on some growth parameters of phasoleous vulgaris was monitored. The Results indicated that OC content of clay soil was positively affected by the amendment of soil with inoculated RP. Inoculation of RP with A.niger culture increased the OC content of the soil by 4.91%, 18.28%, 14.38% and 19.61% comparing to A.fumigatus, NS, RP and SP respectively. the highest soil organic carbon content obtained when soil was amended with inoculated RP in 1/2RD it increased by 1.02% and 7.232% comparing to the amendment of with RD and 2RD. RP inoculated with A.niger culture clay soil showed the highest TN content when amended with 2RD the presence of phasloeus vulgaris plant it was 19.19%. Different phosphate treatments affected MC in clay soil to reach the highest count when inoculated rock phosphate with the RD as a fertilizer it increased by5.66% & 20.75% case of A.fumigatus & A.niger respectively comparing to NS. The lowest count obtained when SP was used as a fertilizer, it decreased by 26.4% comparing to NS.

Introduction Population aging is one of the greatest challenges in contemporary public health. Thus, one of the consequences of this dynamic is a greater demand for health services. The aim of the present research consists in explaining the main topics that justify the fact that the increase of population-aging worldwide influences public health strategies applied. Materials and methods To carry out this review article the search strategies included electronic databases, such as PubMed, Cochrane Library and Science Direct, reference lists of articles, and selected textbooks. Articles and textbooks used in this study were mainly reached by using the following keywords: “Public health”; “Population-ageing “; “Global Aging”; “Elderly” and “Health”. Selection criteria included articles published from 1985 to the present year of 2018. At the end of the search, 11 scientific articles were selected. Results and Discussion The physical / biological, psychological and social changes associated with the elderly leads to decrease of health, withdrawal from the labor market and several unfavorable situations, which cannot be controlled. In this context, the elderly seek to find support in the family, neighborhood, friends and institutions that will influence their quality of life. Therefore, the path of Public Health has three essential points: first, health promotion and primary prevention, which requires a lot of health education to develop healthy living habits and improve understanding of the aging process; secondly, appropriate health treatments, including professionals trained in Geriatrics and Gerontology, aiming at early diagnosis and interdisciplinary administration of diseases, seeking to preserve functional capacity; and finally, the rehabilitation of the functions committed, aiming at functional independence and mental autonomy, in any type of incapacity or limitation. Conclusions Aging is a challenge to be integrated by Public Health and the vulnerability inherent in the elderly should never be seen in a unique way. Thus, we believe…

A theoretical model of a nonlinear network that outlines the general aspects of mole-rat resistance to age-related diseases, such as cancer and the action of ROS was elaborated. According to our conjecture, it was shown that the protection is established because hyaluronic acid of high molecular mass forms a non-linear network of interactions. That network leads to self-organization away from the thermodynamical equilibrium, which appears through a “first order” phase transition as a supercritical bifurcation of Andronov-Hopf type. Finally, it is shown how the rate of entropy production is a Lyapunov function of the dynamics of the process.

Alkaloids are a chemically heterogenous group of natural substances and comprises more than 6000 basic nitrogen containing organic compounds which occur in about 15 percent of all vascular terrestrial plants and in more than 150 different plants families. The alkaloids exhibit diversity of structures and also show an extraordinary spectrum of pharmacological activities. Because of these characters, they are important for chemical, physiological, taxonomic and biogenetic studies.

Myxoma is a rare, benign mesenchymal tumor composed of undifferentiated stellate cells within a myxoid stromaresembling that of the umbilical cord . Apart from cardiac locations, skeletalmuscle involvement is commonly seen around thigh muscles, although other muscles could be affected with intermuscular, para-articular and even subcutaneous subsets. The authors intend to highlight the diagnostic challenge that could arise in the management of what is a benign tumor through a case report and review of relevant literature.