International Journal of Biomedical Engineering Research


Population Dietary Variation of Drosophila Melanogaster Associated with Different Yeasts

Research article of International Journal of Biomedical Engineering Research Population Dietary Variation of Drosophila Melanogaster Associated with Different Yeasts Matheus Alves Siqueira de Assunção1*, Marcos Vinícius da Silva Alves de Lima1, Maria Eduarda dos Santos Pereira De Oliveira1, Bruna Zirpoli Leite Parisi1, Natália Maria de Souza Castro1, Igor Cesar De Oliveira Cirilo1, Fálba Bernadete Ramos Anjos2 1Graduates of the Biological Sciences course - Bachelor's Degree, Biological Sciences Center, Federal University of Pernambuco (UFPE), 2Professor of the Federal University of Pernambuco (UFPE). Objective: To analyze the importance of the quality of the growth medium as to the development of Drosophila melanogaster grown in the laboratory, in order to assess changes in physical fitness and in the survival and fertility rates of the studied populations, both of the White and wild strains, according to the yeast. provided as a food resource. Method: To do this, different yeasts were used as food resources (Saccharomyces cerevisiae, Dekkera bruxelensis and Meyerozyma caribbica) in the standard medium and in order to evaluate the variables, the RING test and analysis of survival and fertility rates were performed. Results: Through the data, the growth medium with Saccharomyces cerevisiae was that with all analyzed rates were within the expected value and that the individuals were able to complete their life cycle, while the other resources did not obtain the expected values. Conclusion: The efficiency of Saccharomyces cerevisiae for maintenance medium is confirmed, in addition to this fact, with the intriguing result of the other two yeasts, it is necessary to add different evaluation methods so that the results become increasingly robust. Keywords: Drosophila melanogaster; growth medium; yeast; resource ...

Detailed Computation of Air-Conditioning Modality within Chimpanzee Nasal Airways

Research article of International Journal of Biomedical Engineering Research Detailed Computation of Air-Conditioning Modality within Chimpanzee Nasal Airways Kaouthar Samarat1,*, Sho Hanida2, Shigeru Ishikawa3, Kazunori Kotani4 and Teruo Matsuzawa4 1Ishikawa Resin Industry Co., Ltd., Ta 1-8 Utani, Kaga-shi, Ishikawa 922-0312, Japan; 2Kanazawa Institute of Technology, 7-1 Ohgigaoka, Nonoichi-shi, Ishikawa 921- 8501, Japan; 3Kanazawa Municipal Hospital, 3-7-3 Heiwamachi, Kanazawa-shi, Ishikawa 921-8105, Japan; 4Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi-shi, Ishikawa 923-1292, Japan Nasal cavity of primates and other animals has been reported in many research works. Lots of the previous studies focused on the nasal airflow but few of them considered the internal nasal air-conditioning phenomena. In this study, we investigated the air-conditioning modality within an anatomically accurate computer nasal airways model of a healthy female adult chimpanzee. The finite volumes method was used to compute a steady laminar inspiratory flow with physiological flow rate of 1.4 m/s, mimicking breathing at rest state. Detailed distributions of air-conditioning in lower, middle and upper airways of the left and right nasal cavities were investigated. The numerical simulation revealed that air-conditioning pattern inside the chimpanzee nasal cavity varies depending to the nasal topology. Keywords: Chimpanzee nasal cavity; Computational fluid dynamics; Nasal air-conditioning ...

Evaluation of antioxidant and gastroprotective activities of ethyl acetate extract of Avicennia schaueriana.

Research article of International Journal of Biomedical Engineering Research Evaluation of antioxidant and gastroprotective activities of ethyl acetate extract of Avicennia schaueriana. Borba A.D.L1; Barbosa J.A.P2; Santana M.A.N3; Coutinho L.L4; Farias L.O5; Silva T.G6 1Student of the Pharmacy Course - UFPE; 2,3,6Researchers of Department of Antibiotics- UFPE; 4,5Students of the Biomedicine Science Course- UFPE Introduction: Brazilian flora has a great biodiversity and some of these plants are used in folk medicine. Avicennia schaueriana, popularly known as black mangrove, is an endemic specie of mangrove vegetation belonging to the Acanthaceae family. The species of the genus Avicennia are widely used by traditional communities for the treatment of tumors, rheumatism, ulcers and wound healing. Objectives: To evaluate the antioxidant and gastroprotective properties of the ethyl acetate extract of Avicennia schaueriana. Methodology: The ethyl acetate extract of the leaves of A. schaueriana (As-AcEOt) was obtained by maceration, and afterwards the phytochemical prospecting was evaluated by thin layer chromatography (TCL). The antioxidant potential of the As-AcEOt was evaluated by free radical scavenging method ABTS+ (2,2-azobis - (3-ethylbenzthiazoline-6-sulfonate). The gastroprotective activity of As-AcEOt (50, 100 and 200 mg/kg) was analyzed by the ethanol-induced ulcer method in Wistar rats. The myeloperoxidase (MPO) levels and histopathological analysis were evaluated in gastric mucosa of the animals treated with As-AcEOt submitted to the model of ulcer induced by ethanol. Results and Discussion: Through TCL was observed the presence of terpenoids, flavonoids and tannins in the extract. The As-AcEOt exhibited antioxidant activity with 73.23% inhibition of the radical ABTS+. In the gastroprotective activity, the As-AcEOt reduced the ulcerative lesion index (ULI), with percentages of ULI of 83.8, 88.5 and 86.9% for the doses of 50, 100 and 200 mg/kg, respectively. The histological analysis showed that As-AcEOt preserved the gastric pits and it did not present hemorrhage and edema. Conclusion: This research ...

Metabolic and immunological modifications present in Alzheimer’s Disease

Review article of International Journal of Biomedical Engineering Research Metabolic and immunological modifications present in Alzheimer's Disease Gonçalves, A.L.N1, Souza, A.V.F2, Borges, B.Q.O.V3, Paiva, J.C.G4, Morais, L.A5, Souza, M.B.R6 1Estudante do Curso de Medicina – UNICAP; 2,3,4,5Estudante do Curso de Medicina – UNICAP; 6Docente do Curso de Medicina – UNICAP Introduction: Alzheimer’s Disease (AD) is classified as progressive neurodegenerative and represents one of the main causes of dementia in the elderly. Its symptomatology is characterized by loss of memory, neuronal destruction and reduction of brain volume. The literature reports a series of metabolic and immunological changes that contribute to the progression of the disease. Objective: To carry out a review of the literature on metabolic and immunological modifications present in Alzheimer’s Disease. Methodology: 34 articles, published between 2008 and 2017, were pre-selected in the SciELO database, using the descriptors: Inflammation + Alzheimer’s Disease; Hypotheses + Alzheimer + Etiology; Alzheimer’s Disease + Lymphocytes; Metabolism + Alzheimer’s. After analysis of the abstracts, 4 articles were analyzed in full. Results and Discussion: The following metabolic alterations were observed in patients with AD: folic acid reduction, arginine reduction and increase of calcium influx to cell. Serum folic acid concentration is reduced in AD patients compared to healthy elderly individuals and has an inverse relationship with the amino acid homocysteine, which can cause apoptosis and increased oxidative stress, leading to cognitive damages that characterize the progression of the disease. Changes in NMDA receptors have also been observed, so glutamate is not reuptake and accumulates in the extracellular environment causing toxicity. In addition, as a consequence, there is a high influx of calcium leading to toxicity and apoptosis of neuronal cells. In relation to the immunological alterations, were found reduction of lymphocytes, increase of interleukin and increase of microglia, which in high quantity produce neurotoxins that contribute ...

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International Journal of Biomedical Engineering Research

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