International Journal of Biomedical Engineering Research


Detailed Computation of Air-Conditioning Modality within Chimpanzee Nasal Airways

Research article of International Journal of Biomedical Engineering Research Detailed Computation of Air-Conditioning Modality within Chimpanzee Nasal Airways Kaouthar Samarat1,*, Sho Hanida2, Shigeru Ishikawa3, Kazunori Kotani4 and Teruo Matsuzawa4 1Ishikawa Resin Industry Co., Ltd., Ta 1-8 Utani, Kaga-shi, Ishikawa 922-0312, Japan; 2Kanazawa Institute of Technology, 7-1 Ohgigaoka, Nonoichi-shi, Ishikawa 921- 8501, Japan; 3Kanazawa Municipal Hospital, 3-7-3 Heiwamachi, Kanazawa-shi, Ishikawa 921-8105, Japan; 4Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi-shi, Ishikawa 923-1292, Japan Nasal cavity of primates and other animals has been reported in many research works. Lots of the previous studies focused on the nasal airflow but few of them considered the internal nasal air-conditioning phenomena. In this study, we investigated the air-conditioning modality within an anatomically accurate computer nasal airways model of a healthy female adult chimpanzee. The finite volumes method was used to compute a steady laminar inspiratory flow with physiological flow rate of 1.4 m/s, mimicking breathing at rest state. Detailed distributions of air-conditioning in lower, middle and upper airways of the left and right nasal cavities were investigated. The numerical simulation revealed that air-conditioning pattern inside the chimpanzee nasal cavity varies depending to the nasal topology. Keywords: Chimpanzee nasal cavity; Computational fluid dynamics; Nasal air-conditioning ...

Evaluation of antioxidant and gastroprotective activities of ethyl acetate extract of Avicennia schaueriana.

Research article of International Journal of Biomedical Engineering Research Evaluation of antioxidant and gastroprotective activities of ethyl acetate extract of Avicennia schaueriana. Borba A.D.L1; Barbosa J.A.P2; Santana M.A.N3; Coutinho L.L4; Farias L.O5; Silva T.G6 1Student of the Pharmacy Course - UFPE; 2,3,6Researchers of Department of Antibiotics- UFPE; 4,5Students of the Biomedicine Science Course- UFPE Introduction: Brazilian flora has a great biodiversity and some of these plants are used in folk medicine. Avicennia schaueriana, popularly known as black mangrove, is an endemic specie of mangrove vegetation belonging to the Acanthaceae family. The species of the genus Avicennia are widely used by traditional communities for the treatment of tumors, rheumatism, ulcers and wound healing. Objectives: To evaluate the antioxidant and gastroprotective properties of the ethyl acetate extract of Avicennia schaueriana. Methodology: The ethyl acetate extract of the leaves of A. schaueriana (As-AcEOt) was obtained by maceration, and afterwards the phytochemical prospecting was evaluated by thin layer chromatography (TCL). The antioxidant potential of the As-AcEOt was evaluated by free radical scavenging method ABTS+ (2,2-azobis - (3-ethylbenzthiazoline-6-sulfonate). The gastroprotective activity of As-AcEOt (50, 100 and 200 mg/kg) was analyzed by the ethanol-induced ulcer method in Wistar rats. The myeloperoxidase (MPO) levels and histopathological analysis were evaluated in gastric mucosa of the animals treated with As-AcEOt submitted to the model of ulcer induced by ethanol. Results and Discussion: Through TCL was observed the presence of terpenoids, flavonoids and tannins in the extract. The As-AcEOt exhibited antioxidant activity with 73.23% inhibition of the radical ABTS+. In the gastroprotective activity, the As-AcEOt reduced the ulcerative lesion index (ULI), with percentages of ULI of 83.8, 88.5 and 86.9% for the doses of 50, 100 and 200 mg/kg, respectively. The histological analysis showed that As-AcEOt preserved the gastric pits and it did not present hemorrhage and edema. Conclusion: This research ...

Metabolic and immunological modifications present in Alzheimer’s Disease

Review article of International Journal of Biomedical Engineering Research Metabolic and immunological modifications present in Alzheimer's Disease Gonçalves, A.L.N1, Souza, A.V.F2, Borges, B.Q.O.V3, Paiva, J.C.G4, Morais, L.A5, Souza, M.B.R6 1Estudante do Curso de Medicina – UNICAP; 2,3,4,5Estudante do Curso de Medicina – UNICAP; 6Docente do Curso de Medicina – UNICAP Introduction: Alzheimer’s Disease (AD) is classified as progressive neurodegenerative and represents one of the main causes of dementia in the elderly. Its symptomatology is characterized by loss of memory, neuronal destruction and reduction of brain volume. The literature reports a series of metabolic and immunological changes that contribute to the progression of the disease. Objective: To carry out a review of the literature on metabolic and immunological modifications present in Alzheimer’s Disease. Methodology: 34 articles, published between 2008 and 2017, were pre-selected in the SciELO database, using the descriptors: Inflammation + Alzheimer’s Disease; Hypotheses + Alzheimer + Etiology; Alzheimer’s Disease + Lymphocytes; Metabolism + Alzheimer’s. After analysis of the abstracts, 4 articles were analyzed in full. Results and Discussion: The following metabolic alterations were observed in patients with AD: folic acid reduction, arginine reduction and increase of calcium influx to cell. Serum folic acid concentration is reduced in AD patients compared to healthy elderly individuals and has an inverse relationship with the amino acid homocysteine, which can cause apoptosis and increased oxidative stress, leading to cognitive damages that characterize the progression of the disease. Changes in NMDA receptors have also been observed, so glutamate is not reuptake and accumulates in the extracellular environment causing toxicity. In addition, as a consequence, there is a high influx of calcium leading to toxicity and apoptosis of neuronal cells. In relation to the immunological alterations, were found reduction of lymphocytes, increase of interleukin and increase of microglia, which in high quantity produce neurotoxins that contribute ...

Evaluation of lectin extracted from Canavalia brasiliensis on the neuropsychomotor system of murine

Research article of International Journal of Biomedical Engineering Research Evaluation of lectin extracted from Canavalia brasiliensis on the neuropsychomotor system of murine Gonçalves, A.L.N1, Souza, A.V.F2, Borges, B.Q.O.V3, Paiva, J.C.G4, Morais, L.A5, Souza, M.B.R6 1Estudante do Curso de Medicina – UNICAP; 2,3,4,5Estudante do Curso de Medicina – UNICAP; 6Docente do Curso de Medicina – UNICAP Introduction: Lectins are a class of proteins extracted from the seeds of Canavalia brasiliensis (Lectin ConBr). Its anti-neoplastic activity has been studied in experimental models. Aim: To evaluate the neuropsychomotor effect of Lectin ConBr in vivo in murine. Methods: Thirty Swiss mice were divided into three groups: GCcontrol (n = 10) administered saline solution; G1experimental (n = 10) 50mg/kg and G2experimental (n = 10) 300mg/kg of Lectin ConBr. The neuropsychomotor analysis was performed by The Open Field Test, 4 and 24 hours after treatment. The statistic was performed by Student’s t-test. Results and Discussion: In the CG, the results obtained after 4h were: ambulation 55.4 ± 16.8; self-cleaning 4.8 ± 1.3; lifting 21.5 ± 3.41 and defecation 0.6 ± 0.5. G1: ambulation 43.4 ± 29.11; self-cleaning 3.4 ± 1.6; lifting 8.0 ± 8.1 and defecation 0.2 ± 0.44. G2: ambulation 63.0 ± 14.58; self-cleaning 1.0 ± 0.7; lifting 12.8 ± 3.1 and defecation 0.2 ± 0.44. The results obtained after 24 hours were: GC: ambulation 62.2 ± 27.9; self-cleaning 2.6 ± 1.5; lifting 15.3 ± 5.8 and defecation 1.4 ± 0.5. G1: ambulation 32.0 ± 15.7; self-cleaning 1.8 ± 1.7; lifting 6.0 ± 6.0; defecation 0.6 ± 0.5. G2: ambulation 62.0 ± 30.1; self-cleaning 0.6 ± 0.5; lifting 16.8 ± 7.3 and defecation 0.4 ± 0.5*. ConBr did not alter the spontaneous movement of the mice after 4 hours, however, the self-cleaning act and the total number of lifting in the treated groups decreased. After 24 ...

Dr.Prakash.MMS.Kinthada
Professor, Department Of Chemistry, Sri Vidya Nikethan Engineering College.Tirupathi ,INDIA

Dr. Kshitij Shinghal
Associate Professor and Dean Academics, MIT Mordabad, Uttar Pradesh

Dr. Shahin Gavanji
Chairman of “WAMS National Council of Iran at World Academy of Medical Sciences (WAMS), Chairman WAMS Oncology Research Group of Iran, Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Khorasgan, Isfahan, Iran, Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran

Dr. Ashish Kumar
Associate Professor ,Department of Chemistry, HOD-Chemistry-School of Civil Engineering, HOD-Chemistry-School of Mechanical Engineering, HOD-Chemical Engineering and CHM-Petroleum Engineering, School of Chemical engineering and Physical Sciences, Lovely Faculty of Technology and Sciences, Lovely Professional University

Dr. Praveen Kumar Sharma
Associate Professor, Department of Chemistry, Lovely Professional University

Dr. Siamak Hoseinzadeh
West Tehran Branch, Islamic Azad University, Tehran, Iran

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1.Kaouthar Samarat, Sho Hanida, Shigeru Ishikawa, Kazunori Kotani, Teruo Matsuzawa.Detailed Computation of Air-Conditioning Modality within Chimpanzee Nasal Airways.International Journal of Biomedical Engineering Research, 2018, 2:6. DOI: 10.28933/ijber-2018-06-1901 
2.Borba A.D.L; Barbosa J.A.P; Santana M.A.N; Coutinho L.L; Farias L.O; Silva T.G. Evaluation of antioxidant and gastroprotective activities of ethyl acetate extract of Avicennia schaueriana.International Journal of Biomedical Engineering Research, 2018, 1:5. DOI: 10.28933/ijber-2018-05-1805

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International Journal of Biomedical Engineering Research (ISSN:2637-6563; DOI:10.28933/IJBER) is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Biomedical Engineering Research.

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