International Journal of Neuroscience Research


The Effect of Nitrendipine and Levetiracetam in Pentylenetetrazole Kindled Rats

Research Article of International Journal of Neuroscience Research The Effect of Nitrendipine and Levetiracetam in Pentylenetetrazole Kindled Rats Meryem Dilek Karakurt1, Süleyman Emre Kocacan2, Cafer Marangoz3 1Ankara Yıldırım Beyazıt University Medical Faculty, Ankara, TURKEY 2Ondokuz Mayıs University Medical Faculty, Samsun, TURKEY 3Istanbul Medipol University Medical Faculty, Istanbul, TURKEY We aimed to investigate the efficacy of L-type voltage gated calcium channel blocker nitrendipine and levetiracetam in pentylenetetrazole (PTZ) kindled male rats. In order to establish kindling model, 35 mg/kg PTZ injected intraperitoneally (i.p.) to male wistar albino rats three days a week. Then, screw electrodes were placed in the skulls of the kindled rats. During the experiments, EEG activities and seizure behaviors of kindled rats were recorded. The kindled rats were divided into control (n=6), PTZ (n=6), nitrendipine (2.5 mg/kg (n=6), 5 mg/kg (n=6), 10 mg/kg (n=6)) and levetiracetam (10 mg/kg (n=6), 20 mg/kg (n=6), 40 mg/kg (n=6)) groups. Nitrendipine (5 mg/kg) and levetiracetam (20 mg/kg) were suppressed the spike frequency and the seizure score effectively (p<0.05). The effective doses of nitrendipine (5 mg/kg) and levetiracetam (20 mg/kg) were administered consecutively to the kindled animals (n=6). The co-administration of nitrendipine (5 mg/kg) and levetiracetam (20 mg/kg) did not effectively decrease the spike frequency and seizure score (p>0.05). The co-administration of nitrendipine and levetiracetam was not more effective than administration of nitrendipine or levetiracetam separately (p>0.05). Keywords: levetiracetam, nitrendipine, kindling model, voltage-gated calcium channels, rat ...

Extraction of dopamine, serotonin, and gamma-aminobutyric acid from lactobacillus.spp and yeast

Research Article of International Journal of Neuroscience Research Extraction of dopamine, serotonin, and gamma-aminobutyric acid from lactobacillus.spp and yeast Pragalya A and Priya Iyer* PG and Research Department of Biotechnology Women`s Christian College, Chennai -600006 Treating the neurological disease is a meticulous process with lots of uncertainties. There is been an increasing demand and improvement of treatments are being under process. Most challenging neurological diseases like Alzheimer’s disease, Parkinson’s diseases are still being under studies for the challenging reasons of their occurence.Also there is an increasing number of studies are going on with the Micro biome-gut-brain axis related findings to the neurological diseases. With such concept, it is significant to know the potentiality of the microbes which are commonly reside in our body to produce the metabolites i.e, Neurotranmitters related to the diseases. In this study focus is to find such microbes. Lactobacillus spp and the yeast commonly found in gut, shows the potentiality to produce the neurotransmitters with using simple laboratory conditions. Keywords: dopamine, serotonin,  gamma-aminobutyric acid, lactobacillus.spp, yeast ...

The experience of using the portfolio as a resource for follow-up of compulsory curricular traineeship in a specialized health college

Research Article of International Journal of Neuroscience Research The experience of using the portfolio as a resource for follow-up of compulsory curricular traineeship in a specialized health college Osório, M.O1, Albuquerque, E.N2, Accioly, C.C3, Pedrosa, A.P.A4, Melo, M.C.B5, Portella, R.B.C6 1,2,3,4,5,6Psicólogas do Instituto de Medicina Integral Professor Fernando Figueira - IMIP, tutoras do curso de Psicologia da Faculdade Pernambucana de Saúde - FPS, Introduction: The processes of acquisition, construction of knowledge and evaluation of student learning in undergraduate courses are constantly discussed in order to propose improvements in teaching and learning. The portfolio is a self-reflective educational resource, developing skills and expanding learning. Objective: report the experience of using the portfolio as a resource for follow-up of compulsory curricular traineeship in a specialized health college. Method: Experience report. Results and Discussion: When they enter the last year of the Psychology course, students are guided on the construction of the reflective portfolio, being an active and fundamental participant in their assembly, developing decision-making skills, analytical and critical in writing their experiences of stages, in the theoretical basis of its activities, which allow it to evaluate its investment, autonomy, possibilities and difficulties in the stage. Conclusion: The use of the portfolio allowed the development of critical thinking, reinventing and innovating the teaching and learning process in the compulsory curricular stage. Keywords: highereducation, psychology, portfolio ...

Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm

Research Article of International Journal of Neuroscience Research Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm Anthony T. Eduviere1, Osarume Omorogbe2 and Solomon Umukoro2* 1Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria 2Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria Passive avoidance task is a rodent model of memory in which the animal learnt to avoid an aversive stimulus precipitated by fear and it is always accompanied by inhibition of motor behavior. We have shown in our previous studies that methyl jasmonate (MJ), a bioactive compound isolated from Jasminum grandiflorum demonstrated memory enhancing effect in hippocampal-dependent memory tasks such as Y-maze and object recognition tests in mice. This present study was designed to investigate if MJ could ameliorate memory deficits associated majorly with the activation of the amygdala in response to an aversive stimulus in the passive avoidance paradigm. The present study also evaluated the effect of MJ on scopolamine (SC)- and lipopolysaccharide (LPS)-induced memory impairment in the passive avoidance paradigm. Mice were given intraperitoneal (i.p) injection of MJ (10-40 mg/kg), donepezil, DP (1 mg/kg) or vehicle daily for 7 days before testing for memory using passive avoidance step-down apparatus. In the interaction studies, the effects of SC (3 mg/kg, i.p.) or LPS (250 µg/kg, i.p.) given alone or with MJ (10, 20, 40 mg/kg) or DP (1 mg/kg) for 7 consecutive days were also evaluated. SC and LPS were injected 30 min after MJ or DP administration. The time it took (step-down latency) the mouse to step down from the elevated vibrating platform onto the grids (electrified stainless steel bars on the floor of the cage), which indicates memory function was recorded. Our findings revealed that MJ (10-40 mg/kg, i.p.) ameliorated memory deficits ...

Dr. Mohd Normani Zakaria
Chairman / Head of Hospital Unit / Assistant Professor, Audiology and Speech Pathology Programme, Universiti Sains Malaysia

Dr. Darshana Narayanan
Head of Research, pymetrics, New York NY

Dr. Ayanabha Chakraborti
Senior Researcher, Department of Surgery, THT-1066, University of Alabama at Birmingham

Dr. Richa Madan Lomash
Research Fellow, Receptor Biology Unit (NINDS), NIH, Bethesda (MD), USA

Dr. Mario Bernardo-Filho
Professor Titular, Universidade do Estado do Rio de Janeiro

Dr. Dhruba Pathak
The University of Tennessee Health Science Center

Dr. Narayanaswamy Venketasubramanian Ramani
Consultant Neurologist, Raffles Hospital, Singapore

Dr. Abdelrahman Y. Fouda
Vascular Biology Center, R.B. Caldwell lab, Augusta University

Dr. Igor Iskusnykh
University of Tennessee Health Science Center

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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