International Journal of Stem Cell Research

Biomedical Applications of Induced Pluripotent Stem Cells

Review Article of International Journal of Stem Cell Research Biomedical Applications of Induced Pluripotent Stem Cells Neveen A. Salem Biochemistry Department, Faculty of Science, University of Jeddah, Saudi Arabia Narcotics, Ergogenic Aids and Poisons Department, Medical Research Division, National Research Centre, Egypt Induced pluripotent stem cells (iPSCs) which are efficiently produced from somatic cells by the introduction of four transcription factors (Oct4, Sox2, Klf4, and c-Myc) in fibroblasts could circumvent the restrictions of multipotent stem cells that obligated to differentiate into only several lineage cells and also, the ethical argument about ESCs that causes oocytes and embryo destruction . In addition, iPSCs are powerful tools applicable in biomedicine, cell therapy, pharmacology and toxicology. Therefore, the use of iPSCs in stem cell therapy has immense prospects and offer remarkable applications in regenerative medicine.This review aimed to summarize the most recent findings on iPSCs and focus on their biomedical applications. Keywords: Biomedical Applications, Induced Pluripotent Stem Cells ...

The Advances in the Use of Stem Cells in Dentistry

Review Article of International Journal of Stem Cell Research The Advances in the Use of Stem Cells in Dentistry Asfora R. L. M1; Oliveira D.M.A2, Lima L.F.A3, Monteiro G.P4, Silva T.S.G5, Maia C.S6 1,2,3,4,5Estudante do Curso de Odontologia/UFPE 6Docente/Pesquisador do Departamento de Histologia e Embriologia/UFPE Stem cells can be used in several areas including dentistry for the formation and regeneration of tissues in the oral cavity. Dental pulp stem cells are able to differentiate into several types, such as fibroblasts, cementoblasts, osteoblasts and odontoblasts. They have great potential for repairing and renewing bone tissues, dentin and dental fixation elements. The reason to use them is becasue they have the ability to differentiate into several cell types according to the stimulus received. Although they have not routinely applied in the clinic, the use may represent a major advance for dentistry, which may help the structural restoration of dental tissues. This study aims to review the literature on the use of stem cells and clarify the potential use of these cells in dentistry. A review of the literature was performed in the virtual libraries VHL and SCIELO with the keywords of "Cells Tronco"; "Dentistry"; "Bioengineering". Following inclusion criteria, articles published from 2012 were established in the Portuguese and Spanish languages that relate the use of stem cells to dentistry. The search resulted in 55 related articles,but six articles met the inclusion criteria. It has been found that stomatognathic system is one of the richest sources of adult stem cells . There are many possibilities in using stem cell techniques in Dentistry, from the use of stem cells in dental losses due to periodontal diseases or cavities to prevent bone resorption. In studies, the mesenchymal stem cells mediated osteogenesis from two to 14 weeks post graft, reflecting the positive result of this application.The ...

Stem Cells in Future Dentistry: Possibility Or Utopia?

Review Article of International Journal of Stem Cell Research Stem Cells in Future Dentistry: Possibility Or Utopia? Santos M.R1; Santos R.C2; S.P.A3; Costa C.L4; Oliveira J.B5 1Estudante do Curso de Odontologia– 1,2,3,4,5 UFPE, Universidade Federal de Pernambuco; 2Estudante do Curso de Odontologia - UFPE.3Estudante do Curso de Fonoaudiologia - UFPE 4Estudante do Curso de Odontologia - UFPE. 5Docente/Pesquisador do Departamento de Anatomia do Centro de Biociências - UFPE. Teeth are organs that perform functions ranging from chewing, support and protection of soft tissues to help in the articulation of words and also an important factor in facial aesthetics. The dental support tissues include dental alveolus, periodontal ligament, cementum and gingiva, which protect and fix the teeth in the alveolar bone. When the teeth or any of supporting tissues were damaged, current techniques used to recover them in dental practice still fail to qualitatively and quantitatively restore all the lost structures. In this scenario, studies suggested that stem cells may stimulate these cells to differentiate in periodontal structures and even the formation of a biodent. A field of science that promotes studies with stem cells is tissue engineering with the objective of studying the possibility of functional and physiological restoration of damaged or lost tissues based on Engineering, Biology and Clinical Sciences.The interest of bioengineering in making dental structures is precisely the advantage of being accessible and not fundamental to life. Regardless of the technique used, three elements are essential in tissue engineering: stem cells, an extracellular matrix for transport of nutrients, oxygen and metabolite residues, and growth factors for coordinating dental morphogenesis. The objective of this study was to perform a literature review on the importance of stem cells in the development of Dentistry. Eleven articles both in Portuguese and English were slected with the search terms included: Dentistry, cells ...

Non-hodgkings Lymphoma

Review Article of International Journal of Stem Cell Research Non-hodgkings Lymphoma Effiong Edet Bassey Dept. of Applied Microbiology and Brewing Nnamdi Azikiwe University, Awka Nigeria Lymphoma is the general term for cancers that develop in the lymphatic system. Lymphoma originates in developing lymphocytes (B-cells and T-cells), which have undergone a malignant change. They multiply without any proper order, forming tumours, which are collections of cancer cells. These tumours cause swelling in the lymph nodes and other parts of the body. Over time, malignant lymphocytes (called lymphoma cells) crowd out normal lymphocytes and eventually the immune system becomes weakened and can no longer function properly. This lymphoma affects the lymph nodes first, and could also affect other lymphoid organs like spleen and bone marrow. The Non-Hodgkins lymphoma can be classified into 2, depending on how fast or slow these tumors grow within the body namely; Aggressive non-hodgkins lymphoma and Indolent non¬ hodgkins lymphoma. Non-hodgkins lymphoma can also be classified based on the type of cells they emanate from namely; B-cells lymphoma and T-cells lymphoma. B-cell lymphoma are lymphomas that arise from developing B-cells, while T-cell lymphoma are lymphomas that arise from T -cells. The causes of non-hodgkins lymphoma includes infection like the Epstein-Barr virus infection in patients from specific geographic regions, exposure to certain chemicals ingredients in herbicides and pesticides such as organochlorine and phenoxy acid can lead to lymphoma and also immunosuppression. The extent to which the lymphoma has spread in body is called the stage of the disease. In stages 1 and 2, lymphoma is limited to one or two areas of the body (early stage). In stages 3 and 4, the disease is more widespread in the body (advanced stage). It's signs and symptoms includes; enlarged lymph node in the neck, fever, excessive sweating, unexplained fatigue, loss of ...

Dr. Mahaboob Vali Shaik
Assistant Professor/Senior Scientist, Department of Genetics & stem cell Research, Narayana Medical College & Hospitals

Dr Shashi Kant Tiwari
Department of Pediatrics, University of California, San Diego (UCSD), School of Medicine, Biomedical Research Facility II (Health Sciences)

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1.Asfora R. L. M; Oliveira D.M.A, Lima L.F.A, Monteiro G.P, Silva T.S.G, Maia C.S. The Advances in the Use of Stem Cells in Dentistr.International Journal of Stem Cell Research. 2018, 1:6
2.Santos M.R; Santos R.C; S.P.A; Costa C.L; Oliveira J.B. Stem Cells in Future Dentistry: Possibility Or Utopia? . International Journal of Stem Cell Research. 2018, 1:5

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International Journal of Stem Cell Research is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in the area of stem cell research.

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International Journal of stem cell research