International Journal of Traditional and Complementary Medicine



Erythropoietic and hepatocurative profile of Yoyo Bitters® – A pilot study

Research Article of International Journal of Traditional and Complementary Medicine Erythropoietic and hepatocurative profile of Yoyo Bitters® - A pilot study Innocent U. Okagu1., Chinelo C. Nkwocha1., Adaeze Obi1., Nkiruka C. Ugochukwu1., Chukwudi Odo1., Christian C. Chibuogwu2*., Joseph C. Ndefo3., Victor N. Ogugua1., Sabinus I. Ofoefule2. and Benjamin C. Ozumba4 1Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria. 2Institute for Drug-Herbal Medicine-Excipient Research and Development, University of Nigeria, Nsukka, Enugu State, Nigeria.3Department of Science Laboratory Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.4Department of Obstetrics and Gynecology, College of Medicine, University of Nigeria, Enugu Campus. The present study evaluated the effects of a branded Nigerian polyherbal formulation, Yoyo® bitters on the haematological and biochemical status of hydrogen peroxide (H2O2)-intoxicated rats. Thirty (30) healthy male Wistar rats used in this study were divided into 6 groups of 5 rats each. Group 1 served as normal control and received 3 ml/kg body weight (b.w.). of distilled water only while group 2 served as experimental control and was intoxicated with H2O2 without treatment. Rats in groups 3-5 were H2O2-intoxicated and treated with 1, 2 and 3 ml/kg b.w. of Yoyo® bitters respectively while rats in group 6 were H2O2-intoxicated and treated 100 mg/kg. b.w. of silymarin. H2O2 was administered intraperitoneal on day 0 while drugs were orally administered from days 0 to 14. The rats were sacrificed on day 15 and blood samples collected were subjected to haematological and biochemical analyses. Intoxication with H2O2 significantly (p < 0.05) induced haematotoxicity, oxidative stress and hepatotoxicity when compared with control. Treatment of intoxicated rats with the formulation restored the haematological and biochemical status to normal, suggesting that Yoyo® bitters has erythropoietic and hepatocurative effects. However, future studies are required to confirm these effects in different in vivo models. Keywords: Yoyo® bitters, hepatocurative, haematology, ...

Azaraqi (Strychnos nux-vomica L.) herb for nervous and musclos-keletol system

Review Article of International Journal of Traditional and Complementary Medicine Azaraqi (Strychnos nux-vomica L.) herb for nervous and musclos-keletol system *Shabnam Anjum Ara1, Mohd. Urooj2, Gulam Mohammed Husain2, Uzma Viquar3, Muskula Anudeep Reddy4, Munawwar Husain Kazmi5 Department of Pharmacology, Central Research Institute of Unani Medicine Hyderabad 500038, Telangana, India Nature has always been a giver, bearing rich heritage of natural products which arebeing utilized by mankind since their existence. Azaraqi (Strychnos nux-vomicaL.) is a potential herb used for the treatment of various neuronal illness, muscloskeletol and joint disorders. This comes under category IV of drugs as per Unani literature which needs to be detoxified prior to clinical use.The healing properties of Azaraqi (Strychnos nux-vomicaL.) are substantially those of the alkaloids strychnine and brucine, which are considered toxic.The perception of lesser side effects of herbal formulation among the people especially in developing countries raised the market of treatment by natural products. However, there is need to put forward the scientific evidence of these formulation regarding toxicity as well as efficacy as then only evidence based medicine would only be able to make position in globalized world as an alternative of conventional treatment available. This review article will discuss the potential pharmacological actions; toxicity developed due to Azaraqiresulted out in different preclinical and clinical studies. The authors will try to make a suggestion for future based on finding of these studies. Keywords: Herbal drug, Azaraqi, strychnine, brucine ...

Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus(L.) G. Don, Annona muricata L.)

Review Article of International Journal of Traditional and Complementary Medicine Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus(L.) G. Don, Annona muricata L.) Pawan Kumar Sagar*1, R P Meena4, Mohd Washim Ahmad3, Kunal Sajwan4 *1.2,3. Drug StandardizationResearch Institute, (CCRUM., Ministry of AYUSH.), PLIM., Campus, Kamlanehru nagar, Ghaziabad, U.P. ,India; 4. Central Council for Research of Unani Medicine, Ministry of AYUSH., Janakpuri, D-Block, New Delhi, India Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity.Present Article reviewed three important medicinal plants i.e.- Taxus baccata L. Or Taxus baccata Thunb., Catharanthus roseus(L.) G.Don and Annona muricata L. which traditionally used since ancient time for the treatment and prevention of Cancer and Tumor in Sothern, Northern-east and Himalayan region of India. Having active phytochemical constitutents Taxanes- Alkaloids(Taxol and Taxotere), Larotaxel,nab-Paclitaxel present in T. baccata L. Or T.baccata Thunb. and Vinca-Alkaloid as Vinblastine, Vincristine, Vinorelbine, Vinflunine, catharanthine and vindoline alkaloids in Catharanthus roseus(L.) G.Don, as well as Muricin J, Muricin K, Muricin L, Cinnamic acid derivative, Coumaric acid hexose, Annomuricin A, Annomuricin B, Annomuricin C, Annomuricin E, Annomutacin, Annhexocin, Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, Annonacin A, Annopentocin A, Annopentocin B, Annopentocin C etc. present in A muricata L. This report also revealed the ethno-botanicaly and biological activities of active principles of these plants that will help in noval drug discovery, noval new active phytochemical constituents of anti-cancer and anti-tumor formulations and development of pharmacopial standareds. Keywords: Anti-cancerous, Anti-tumorous, medicinal plants, bio-actives constituents, bio available, ethno-botany ...

Standardization and HPTLC. Fingerprinting study of Poly Herbal Unani Formulation – Habb-e-Sara Khas

Research Article of International Journal of Traditional and Complementary Medicine Standardization and HPTLC. Fingerprinting study of Poly Herbal Unani Formulation - Habb-e-Sara Khas 1Pawan Kumar Sagar*,2R.Murugeswaran, 3Rampratap Meena, 4S. Mageswari and 5P. Meera Devi Sri, 6 Shahidul Khair 1&6Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PLIM Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India., 3Central Council for Research in Unani Medicine,(Under Ministry of AYUSH., Govt. of India),61-62, Institutional Area, Janakpuri, New Delhi, India.,4,5Drug Standardization Research Unit and 2Survey of Medicinal Plants Unit, Regional Research Institute of Unani Medicines, (Under CCRUM, Ministry of AYUSH., Govt. of India), Royapuram, Chennai, T.N., India. Standardization is used to describe all measures under taken during the manufacturing process and quality control of drug assuring its reproducible quality. Most of the traditional medicine are effective but still they lack in its standard parameters. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Habb-e-Sara Khas is therapeutically useful in the treatment of Sara Khas (Epilepsy and Infantile epilepsy). The drug Habb-e-Sara Khas was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-VI), Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprints, quality control and assurance parameters, using WHO guideline to ascertain the quality of drug. The physico-chemical data showed that the drug contain moisture(1.89%), total ash (5.43%),acid in-soluble(1.06%), alcohol and water soluble extractive matter (19.39%) and(60.34%),pH(1% solution) (5.93),pH(10% solution)(5.67), ASSE(18.07%) and CSSE (17.43%), Bulk density of granules(0.4989) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, The evaluated standards will very much useful for laying the phamacopoeial standards of Habb-e-Sara Khas ...

Editor-in-chief: 

Dr. Papiya Bigoniya Professor, Radharaman College of pharmacy, Radharaman Group of Institutes, India.

Editors:

Dr. Zhaoxiang Bian
Associate Vice-President, Chair Professor of School of Chinese Medicine, Director of Clinical Division and Associate Director of Institute of Creativity, Hong Kong Baptist University.

Dr. Woo-Sang Jung
Professor of Cardiology and Neurology (Stroke Center), College of Korean Medicine, Director of Korean Medical Emergency Room, Hospital of Korean Medicine, Kyung-Hee University.

Dr. M J Nanjan
Professor, Physical Chemistry (Retd.) of University of Madras, Chennai, India.

Dr. Daniel Man-yuen SZE
Deputy Program Coordinator for Master of Laboratory Medicine, School of Health & Biomedical Sciences and Health Innovations Research Institute (HIRi), RMIT University, Australia.

Dr. Shamim Ahmad
Professor of Microbiology, Officer In-Charge (Head) & Teacher In-Charge (Administrations), Microbiology Section, Institute of Ophthalmology, Faculty of Medicine , Aligarh Muslim University, India.

Dr. Qingwen Zhang
Associate Professor, Institute of Chinese Medical Sciences (ICMS), University of Macau.

Dr. Ansiur Rahman Khuda-Bukhsh
Former Head, Deptt. of Zoology, University of Kalyani, Presently an Emeritus Professor, University Grants Commission, Govt. of India, at  University of Kalyani.

Dr. Bajpayee Kaptain Kishor
Assistant Professor &HOD in the Botany Department, DR.RML P.G. COLLEGE (C.S.J.M. UNIVERSITY), HARDOI 241001 INDIA.

Dr. Hua-chuan Zheng
Professor, Cancer Research Center; Laboratory Animal Center; The Key Laboratory of Brain and Spinal Injury of Liaoning Province, Laboratory Animal Center, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, China.

Dr. Emre Yalcinkaya
ESC Training Fellow in Electrophysiology, Clinic of Cardiology, University Hospital Zurich, Zurich, Switzerland.

Dr Zhi-Ling YU
Associate Professor, Teaching and Research Division, Fellow, Center for Cancer and Inflammation Research, Director, Master of Pharmaceutical Sciences in Chinese Medicine, Director, Consun Chinese Medicines Research Centre for Renal Diseases, Associate Director, Technology Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Dr. Mario Bernardo-Filho
Professor Titular, Universidade do Estado do Rio de Janeiro

Dr Shivani Sanjeev Gavande
Associate professor, Kayachikitsa at Dr. J.J.Magdum Ayurved medical college, Jaysingpur

Dr. Hiroyasu Satoh
Professor, Health Life Science, Shitennoji University, Habikino, Osaka 583-8501, Japan.

Dr. Paolo Roberti di Sarsina
Chairperson, Traditional Complementary and Alternative Medicine of the Observatory and Methods for Health, University of Milano-Bicocca, Milano, Italy.

Dr. Yibin Feng
Professor & Associate Director (Education), School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Dr. Afrozul Haq
Professor & Principal Scientist, R & D Division, VPS Healthcare, Abu Dhabi, United Arab Emirates (UAE).

Dr Manuel Fernandes Ferreira

Full Professor, Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre, S/N Edifício FC4.Portugal.

Dr Jennifer Hunter
Senior Research Fellow, National Institute of Complementary Medicine, Western Sydney University, Australia.

Dr. Jiahong Lu
Assistant Professor, Institute of Chinese Medical Science, The University of Macau.

Dr. William Cho
Queen Elizabeth Hospital, Hong Kong.

Dr. Wenzhe Ma
Assistant Professor, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau.

Dr Swapnil Sabgonda Patil
Assistant Professor, Dept. of Rognidan Avum Vikrutividnyan

Dr. Hongjie Zhang
Associate Professor, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.

Dr. Nitin Mantri
Senior Lecturer in Biotechnology, Health Innovations Research Institute, School of Science, RMIT University, Victoria,  Australia.

Dr Dudhamal Tukaram Sambhaji
Assistant Professor, Dept. of Shalya Tantra, IPGT&RA,Gujarat Ayurveda University, Jamnagar, Gujarat, India.

Dr Thomas Harris
Complex Health Management, 85 Jubilee Av. Forest Lake. Q 4078. Australia.

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1. M. B. FALANA, M. O. BANKOLE and A. M. OMEMU. In Vivo effects of dosage of leaf, bark and root extracts of V. paradoxa on diarhoea-induced albino rats.International Journal of Traditional and Complementary Medicine 2018, 3:8. DOI: 10.28933/ijtcm-2018-07-0401 
2. Hemanth Kumar Manikyam, C.Ramesh, Krishna Mohan Poluri, Harinath Reddy Kasireddy, Charitha Devi Mekala.Bio-enhancement effect of Bos primigenius indicus urine isolates on Curcumin anticancer activity using different human cell line models of A549, Hep-G2, MCF-7, Jurkat and K562 .International Journal of Traditional and Complementary Medicine 2017, 2:2. DOI: 10.28933/ijtcm-2017-11-2001 

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