Acute renal attack after treatment with Carapa Procera oil: two cases at the Ziguinchor Peace Hospital (Senegal West Africa) and review of the literature
We describe two cases of impaired secondary renal function to a Carapa Procera taking as part of traditional treatment in Ziguinchor, southern Senegal. The certain or suspected toxicity of Carapa Procera is little known in the literature. In the two reported observations, no cause but the traditional treatment was found to explain the clinical picture presented. The development was favorable in all cases after medical treatment and a few hemodialysis sessions. we insist on the difficult context of investigation of these accidents, on the medical ignorance of these practices in sub-Saharan Africa and in Senegal in particular, as well as on the necessary collaboration with local botanists knowledgeable in traditional medicine.
Food allergy is defined as a pruritic dermatitis which is indicated by allergic reactions to food components. Due to its excessive incidence of clinical signs it is necessary to determine the correct diagnosis, provide sufficient control and long term management to achieve comfortable way of life for an animal. In case of very intensive pruritus there are usually used in common medicine glucocorticoids, antihistamincs and inhibitors of Janus kinase but there are also other alternatives such as bioresonance, homeopathy, phytotherapy, acupuncture, etc. that have also very beneficial and curative effect in case of food allergy. Diagnostics and therapy by bioresonance are alternative methods used in modern medicine that was discovered as a combination of quantum physics and Traditional Chinese Medicine. We can use it for various types of acute and chronic diseases without any invasive intervention into the body. There have been positive results in the diagnosis and treatment of allergies in dogs, which are nowadays constantly increased, and that have been one of the most common causes of dermatological and gastrointestinal diseases.
The present study evaluated the effects of a branded Nigerian polyherbal formulation, Yoyo® bitters on the haematological and biochemical status of hydrogen peroxide (H2O2)-intoxicated rats. Thirty (30) healthy male Wistar rats used in this study were divided into 6 groups of 5 rats each. Group 1 served as normal control and received 3 ml/kg body weight (b.w.). of distilled water only while group 2 served as experimental control and was intoxicated with H2O2 without treatment. Rats in groups 3-5 were H2O2-intoxicated and treated with 1, 2 and 3 ml/kg b.w. of Yoyo® bitters respectively while rats in group 6 were H2O2-intoxicated and treated 100 mg/kg. b.w. of silymarin. H2O2 was administered intraperitoneal on day 0 while drugs were orally administered from days 0 to 14. The rats were sacrificed on day 15 and blood samples collected were subjected to haematological and biochemical analyses. Intoxication with H2O2 significantly (p < 0.05) induced haematotoxicity, oxidative stress and hepatotoxicity when compared with control. Treatment of intoxicated rats with the formulation restored the haematological and biochemical status to normal, suggesting that Yoyo® bitters has erythropoietic and hepatocurative effects. However, future studies are required to confirm these effects in different in vivo models.
Nature has always been a giver, bearing rich heritage of natural products which arebeing utilized by mankind since their existence. Azaraqi (Strychnos nux-vomicaL.) is a potential herb used for the treatment of various neuronal illness, muscloskeletol and joint disorders. This comes under category IV of drugs as per Unani literature which needs to be detoxified prior to clinical use.The healing properties of Azaraqi (Strychnos nux-vomicaL.) are substantially those of the alkaloids strychnine and brucine, which are considered toxic.The perception of lesser side effects of herbal formulation among the people especially in developing countries raised the market of treatment by natural products. However, there is need to put forward the scientific evidence of these formulation regarding toxicity as well as efficacy as then only evidence based medicine would only be able to make position in globalized world as an alternative of conventional treatment available. This review article will discuss the potential pharmacological actions; toxicity developed due to Azaraqiresulted out in different preclinical and clinical studies. The authors will try to make a suggestion for future based on finding of these studies.
Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus(L.) G. Don, Annona muricata L.)
Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity.Present Article reviewed three important medicinal plants i.e.- Taxus baccata L. Or Taxus baccata Thunb., Catharanthus roseus(L.) G.Don and Annona muricata L. which traditionally used since ancient time for the treatment and prevention of Cancer and Tumor in Sothern, Northern-east and Himalayan region of India. Having active phytochemical constitutents Taxanes- Alkaloids(Taxol and Taxotere), Larotaxel,nab-Paclitaxel present in T. baccata L. Or T.baccata Thunb. and Vinca-Alkaloid as Vinblastine, Vincristine, Vinorelbine, Vinflunine, catharanthine and vindoline alkaloids in Catharanthus roseus(L.) G.Don, as well as Muricin J, Muricin K, Muricin L, Cinnamic acid derivative, Coumaric acid hexose, Annomuricin A, Annomuricin B, Annomuricin C, Annomuricin E, Annomutacin, Annhexocin, Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, Annonacin A, Annopentocin A, Annopentocin B, Annopentocin C etc. present in A muricata L. This report also revealed the ethno-botanicaly and biological activities of active principles of these plants that will help in noval drug discovery, noval new active phytochemical constituents of anti-cancer and anti-tumor formulations and development of pharmacopial standareds.
Standardization is used to describe all measures under taken during the manufacturing process and quality control of drug assuring its reproducible quality. Most of the traditional medicine are effective but still they lack in its standard parameters. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Habb-e-Sara Khas is therapeutically useful in the treatment of Sara Khas (Epilepsy and Infantile epilepsy). The drug Habb-e-Sara Khas was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-VI), Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprints, quality control and assurance parameters, using WHO guideline to ascertain the quality of drug. The physico-chemical data showed that the drug contain moisture(1.89%), total ash (5.43%),acid in-soluble(1.06%), alcohol and water soluble extractive matter (19.39%) and(60.34%),pH(1% solution) (5.93),pH(10% solution)(5.67), ASSE(18.07%) and CSSE (17.43%), Bulk density of granules(0.4989) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, The evaluated standards will very much useful for laying the phamacopoeial standards of Habb-e-Sara Khas and also in providing the quality medicine to needful human beings.
Preparation and characterization of curcumin-loaded silica nanoparticles and their in-vivo anti-cancer activity evaluation
Curcumin [(1E,6E)-1,7-bis (4-hydroxy- 3-methoxyphenyl) -1,6- heptadiene-3,5-dione)], a polyphenolic compound derived from dietary spice turmeric, has numerous biological and pharmacological activities. It is currently being used for treating several disorders, including cancer. Keeping in view its importance, the curcumin was embedded in the silica nanoparticles prepared by reaction of Tween-40, n-Butanol, triethoxyvinylsilane and 3-aminopropyltriethoxysilane using water as solvent. After completion of reaction, the nanoparticles were obtained by dialysis of the reaction mixture. The nanoparticles were characterized by SEM, TEM, DLS and XRD analyses. The SEM, TEM and DLS analysis shows the average particle size to be 70nm, 66 nm and 75.72nm respectively. Further in-vivo studies were conducted on wistar rats to determine the maximum tolerance dose (MTD) of nanoparticles and study the anti-cancer potential by tumor regression analysis. The MTD was found to be 10 mg/kg body weight of wistar rats and curcumin-doped ORMOSIL nanoparticles in comparison with pure curcumin revealed the highly significant results in tumor regression in EAT induced tumor model.
Yoruba traditional healing system has being in practice for several centuries, yet, there are still certain complexities which set confusion in understanding its conceptualization. Due to lack of enough information about the practice, cynicism, religious bigotry against the practice and over-westernization of healthcare system in Yoruba society, basic features of Yoruba traditional healing system are still obscured. Conceptualization of the healing is narrowed and reduced to fetish; its epistemology is linked with Satan, and organization of Yoruba traditional healing is regarded as unscientific among other complexities suffered by the healing system. This continues to hamper the acknowledgment of its contributions to sustainable healthcare development. Through ethnographic data collection techniques using key informants’ interviews, observation, case study analysis and ethno-botanical survey conceptualization of traditional healing in Yoruba worldviews is examined. Despite the wave of social change influencing the practice of healing in Yoruba society, Yoruba traditional healing system is still resilient, rational and scientific. It features organization of service, providing all- inclusive health caring; with professionalization and specialization in health care service. Since Yoruba healing system is indigenous to the people, it has to be sustained by providing enough information that can explain and contextualize its practices.
Many lay people along with some so called “key opinion leaders” have a common slogan “There’s no answer for cancer”. Again, mistake delays proper treatment and make situation worse, more often. Compliance is crucial to obtain optimal health outcomes, such as cure or improvement in QoL. Patients may delay treatment or fail to seek care because of high out-of- pocket expenditures. Despite phenomenal development, conventional therapy falls short in cancer management. There are two major hurdles in anticancer drug development: dose-limiting toxic side effects that reduce either drug effectiveness or the QoL of patients and complicated drug development processes that are costly and time consuming. Cancer patients are increasingly seeking out alternative medicine and might be reluctant to disclose its use to their oncology treatment physicians. But there is limited available information on patterns of utilization and efficacy of alternative medicine for patients with cancer. As adjuvant therapy, many traditional medicines shown efficacy against brain, head and neck, skin, breast, liver, pancreas, kidney, bladder, prostate, colon and blood cancers. The literature reviews non-pharmacological interventions used against cancer, published trials, systematic reviews and meta-analyses.
A survey of South African plant species used for the treatment of “u wela” in Venda culture, Limpopo Province
Medicinal plants are widely recognized as the key component for critical human health, social and economic support. The current study was conducted to identify medicinal plants used by local people and traditional healers to treat “u wela” in Vhembe District, Limpopo, South Africa. A questionnaire was designed to gather information on the local names of plants, plant parts used and methods of preparation administered by the traditional healers. Plant species were collected based on indigenous knowledge of local traditional healers through the use of a questionnaire and personal interviews, and some were identified using literature and herbarium at the University of Limpopo. The study revealed that thirty-seven medicinal plants are used for treatment of “u wela” in the study area. The frequency index was calculated and the highest frequency was observed in Elaeodendron transvaalensis Jacq (47%) and the least were found in Albizia versicolor Welw. Ex Oliv (6%). Some medicinal uses of identified plants which have not been recorded in the consulted literature were documented. Noticeably, many of these plants were grown in the wild. Traditional healers use different plant part(s) for the treatment of various ailments. Roots (40%) were highly used followed by 20%, bark (13%) and leaves. The plant forms used were trees, (38%), shrubs, (3%), climbers, herbs and succulents (4.7%) belonged to the herbs and succulents. The results stipulated that a high population of people in the community still relied on traditional medicine for their primary health care.