Research Journal of Pharmacology and Pharmacy

Research Article of Research Journal of Pharmacology and Pharmacy PUNICA GRANATUM Vrs COVID – 19 Fruit to Drug Deepak Bhattacharya1*, Dr. P K Mohanta. MD (Ay)2, Dr. Debasish Mishra3, Dr. K C Sethy4, Dr. Jyotsana Sharma5, Dr. P K Pradhan6, Dr. Vahideh Samadiyan7, Dr. Mahtab Pouyanfar8, Dr. Parisa Mohamadpour9, Prof. Ghassem Habibi Bibalani10 1Research & Nursing, At Fight-Cancer at Home, Sri Radha Krishna Raas Mandir, Kedar Gouri Road, Bhubaneswar–751002,Odisa, India. 2MD (Ay), Govt Drug Inspector; Registrar Ay Council; Principal. IGMMC & Hospital, H-2/58,SS Enclave, Khandagiri,Bhubaneswar-751030, Odisa. 3MBBS, Director, Model Blood Bank, Capital Hospital (Govt., Apex) – Bhubaneswar, Odisa, India. 4LLM, Ph.D, Advocate, District & Sessions Court, Bhubaneswar, Odisa, India. 5Ph.D; Director (Act) & Principal Scientist (Plant Pathology) ICAR-National Research Centre  on  Pomegranate, Solapur, Maharastra, India, 413255. 6BAMS, Medical Officer, Indian Red Cross Society Clinic (Ay), Koraput, Odisa, India. 7Ph.D, Lecturer, University of Applied Science and Technology, Shahid Sardari Branch, Tabriz, East Azerbaijan. 8Ph.D, Instructor, TVTO-Medicinal Plants, Teheran, Iran. 9Ph.D, Asst Prof. Forest & Rangeland Research & Watershed Management Dept; Gilan Agril & Natural Resources Research & Edu center; Rasht, Iran. 10Department of Natural Resources, Shabestar Branch, Islamic Azad University, Shabestar, Iran Punica granatum is historically known worldwide as a versatile medicinal fruit. 2 major varieties are presented (i) indo Ayurvedic type (Punica Ayurvedica ?) that is small, harsh and yields no juice and (ii) the juice variety which is commercialised. Indo-Iranian joint effort presents a tome of textual data pertaining to the medicinal aspects of Punica. Gallagic group. Enantiomers. Antagoniostic. Ayurvedic texts and Occidental research modelled papers in tabulated form chronologically succinctly bringing out the evidence based historiography & medico-cultural heritage. On such platform a range of formulations; fruit-to-finished product are presented for the 1st time machine makeable and very specifically also by hand, at home. Poly pathology spectrum; versatile therapeutic ...

Research Article of Research Journal of Pharmacology and Pharmacy Evaluation of the Antioxidant Potential of Artisanal Liqueurs Produced From Fruits of the Caatinga Biome João Victor de Oliveira Alves1*, Francisco Henrique da Silva1, João Carlos de Oliveira Pinto1, Janderson Weydson Lopes Menezes da Silva2, Paloma Maria da Silva1, Irivânia Fidelis da Silva Aguiar1, Katharina Marques Diniz1, Fálba Bernadete Ramos dos Anjos3, Márcia Vanusa da Silva1 1Biochemistry Department, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil; 2Aggeu Magalhães Institute (IAM) - FIOCRUZ/PE , Brazil; 3Department of Histology and Embryology, Universidade Federal de Pernambuco, Recife, Pernambuco,Brazil Plant extraction is a common practice performed in community with the presence of native species with strong population interest. For many Brazilian regions, extractivism acts as a complement of income for the population. The present work aimed to evaluate artisanal liqueurs produced in local communities of the State of Pernambuco in order to observe the antioxidant potentials present during production stages. For this, trials were performed with dpph and abts radicals. All the liqueurs evaluated showed antioxidant potential, with expressive results through the sequestration of the DPPH radical, comprising values of 50 CI between 0.5 and 2.25. Keywords: Caatinga. Antioxidant. Natural products ...

Research Article of Research Journal of Pharmacology and Pharmacy Anti-inflammatory Activity of Saccharum Officinarum Linn (Poaceae) Juice in Animal Models Agbaje Esther Oluwatoyin, Ayinla Adebola Christina, **Ujomo Tejumade Department Of Pharmacology, Therapeutics & Toxicology, College Of Medicine, University Of Lagos; **Department Of Pharmacology And Therapeutic, University Of Ibadan, Oyo State, Nigeria. Saccharum officcinarum (SOC) juice has been used for treatment and management of several conditions including urinary tract infection, diabetes, constipation, tooth decay and bad breath according to folklore. This study was carried out to explore the anti-inflammatory effects of the juice of Saccharum officinarum in doses of 2.5, 5.0, 10.0 and 20.0 mL/kg using the following models in rats - carrageenan, histamine, serotonin, formalin-induced paw oedema, and cotton-pellet granuloma. Also employing the following models in mice - castor oil-induced diarrhea and xylene-induced ear oedema. Animals were pretreated with aspirin (100 mg/kg; p.o), cyproheptadine (10 mg/kg; p.o.), atropine (1 mg/kg p.o), dexamethasone (5 mg/kg; p.o.) and celecoxib (20 mg/kg p.o.).  Oral administration of SOC juice significantly (p<0.001) reduced the right hind paw circumference induced by carrageenan, histamine, serotonin and formalin compared to control group. Furthermore, it inhibited xylene-induced ear oedema with peak effect at 20 mL/kg, as well as castor oil-induced diarrhea and cotton pellet granuloma with peak effect at 10 mL/kg. The anti-inflammatory activities of SOC were significant (p<0.05) when compared with aspirin, cyproheptadine and dexamethasone. The study revealed the potent anti-inflammatory activities of the juice of S. officinarum. Keywords: Saccharum officinarum, anti-inflammatory, carrageenan, aspirin, histamine, rat ...

Research Article of Research Journal of Pharmacology and Pharmacy Analysis and Impact of Evidence Based Medicine in the Process of Education and Decision Making in Medical Practice 1Lana Lekic, 2Alen Lekić, 3Ervin Alibegović,4Jasna Rahimić,5Amrain Maša  1mr.ph. spec, PhD, Faculty of Health Studies, University of Sarajevo, Sarajevo, Bosnia and Herzegovina; 2MD spec, MSc, Sanofi d.o.o., Sarajevo, BiH; 3MD, PhD, Faculty of Medicine, University of Tuzla, BiH; 4mr.ph., Mixed middle school of Chemistry, Tuzla, BiH; 5mr.ph. spec, Boehringer Ingelheim d.o.o., Sarajevo, BiH Evidence Based Medicine (EBM) is one of the modern systems of collecting, recording and using information and data related to medicine. The research was conducted in 2018 in several health institutions (health centers and hospitals) in Sarajevo Canton. The sample was made up of family doctors and other clinical specialties. The research results suggest the doctors in BiH are familiar with the concept of Evidence Based Medicine (EBM) and in their everyday work they apply relevant contemporary knowledge, national and international guidelines for the treatment and disease therapy. The most significant obstacle to more efficient management of medical information and the implementation of EBM in practice is the perception it would require additional time and incur significant cash expenditures to the doctors. In the future, doctors will increasingly be demanded to use advanced tools and modern techniques supporting them to make the most effective treatments on the basis of their own experience. Keywords: EBM - Evidence Based Medicine, EBM application in medical practice, EBM in medical institution in Sarajevo Canton ...