Research Journal of Pharmacology and Pharmacy


Anti-inflammatory Activity of Saccharum Officinarum Linn (Poaceae) Juice in Animal Models

Research Article of Research Journal of Pharmacology and Pharmacy Anti-inflammatory Activity of Saccharum Officinarum Linn (Poaceae) Juice in Animal Models Agbaje Esther Oluwatoyin, Ayinla Adebola Christina, **Ujomo Tejumade Department Of Pharmacology, Therapeutics & Toxicology, College Of Medicine, University Of Lagos; **Department Of Pharmacology And Therapeutic, University Of Ibadan, Oyo State, Nigeria. Saccharum officcinarum (SOC) juice has been used for treatment and management of several conditions including urinary tract infection, diabetes, constipation, tooth decay and bad breath according to folklore. This study was carried out to explore the anti-inflammatory effects of the juice of Saccharum officinarum in doses of 2.5, 5.0, 10.0 and 20.0 mL/kg using the following models in rats - carrageenan, histamine, serotonin, formalin-induced paw oedema, and cotton-pellet granuloma. Also employing the following models in mice - castor oil-induced diarrhea and xylene-induced ear oedema. Animals were pretreated with aspirin (100 mg/kg; p.o), cyproheptadine (10 mg/kg; p.o.), atropine (1 mg/kg p.o), dexamethasone (5 mg/kg; p.o.) and celecoxib (20 mg/kg p.o.).  Oral administration of SOC juice significantly (p<0.001) reduced the right hind paw circumference induced by carrageenan, histamine, serotonin and formalin compared to control group. Furthermore, it inhibited xylene-induced ear oedema with peak effect at 20 mL/kg, as well as castor oil-induced diarrhea and cotton pellet granuloma with peak effect at 10 mL/kg. The anti-inflammatory activities of SOC were significant (p<0.05) when compared with aspirin, cyproheptadine and dexamethasone. The study revealed the potent anti-inflammatory activities of the juice of S. officinarum. Keywords: Saccharum officinarum, anti-inflammatory, carrageenan, aspirin, histamine, rat ...

Analysis and Impact of Evidence Based Medicine in the Process of Education and Decision Making in Medical Practice

Research Article of Research Journal of Pharmacology and Pharmacy Analysis and Impact of Evidence Based Medicine in the Process of Education and Decision Making in Medical Practice 1Lana Lekic, 2Alen Lekić, 3Ervin Alibegović,4Jasna Rahimić,5Amrain Maša  1mr.ph. spec, PhD, Faculty of Health Studies, University of Sarajevo, Sarajevo, Bosnia and Herzegovina; 2MD spec, MSc, Sanofi d.o.o., Sarajevo, BiH; 3MD, PhD, Faculty of Medicine, University of Tuzla, BiH; 4mr.ph., Mixed middle school of Chemistry, Tuzla, BiH; 5mr.ph. spec, Boehringer Ingelheim d.o.o., Sarajevo, BiH Evidence Based Medicine (EBM) is one of the modern systems of collecting, recording and using information and data related to medicine. The research was conducted in 2018 in several health institutions (health centers and hospitals) in Sarajevo Canton. The sample was made up of family doctors and other clinical specialties. The research results suggest the doctors in BiH are familiar with the concept of Evidence Based Medicine (EBM) and in their everyday work they apply relevant contemporary knowledge, national and international guidelines for the treatment and disease therapy. The most significant obstacle to more efficient management of medical information and the implementation of EBM in practice is the perception it would require additional time and incur significant cash expenditures to the doctors. In the future, doctors will increasingly be demanded to use advanced tools and modern techniques supporting them to make the most effective treatments on the basis of their own experience. Keywords: EBM - Evidence Based Medicine, EBM application in medical practice, EBM in medical institution in Sarajevo Canton ...

EXOGENOUS INTOXICATIONSIN THE MUNICIPALITIES OF GERES V-PE

Research Article of Research Journal of Pharmacology and Pharmacy ANALYSIS OF EXOGENOUS INTOXICATIONSIN THE MUNICIPALITIES OF GERES V-PE, FROM 2009 TO 2013 PACHECO ICO1, LOPES LGF1, BEZERRA PB1, FREITAS JMM1, NUNES MGS1, PEDROZA RM1,2 Federal University of Pernambuco (UFPE)1, Federal University of Rio Grande of Norte (UFRN)2 Analyzing the exogenous poisonings in the municipalities of GERES V-PE, in the period 2009 to 2013, from the National System for Notifiable Diseases - SINAN. There was conducted a quantitative, cross-sectional, descriptive and exploratorystudy, from the survey of secondary exogenous poisoning data, recorded inregional SINAN. In SINAN 170 of exogenous poisoningcases were recorded, predominating medicines with 27 % of cases, the main age group was of 15-29 years old, with 32,9 %, and females prevailed with 57,6  %. The weakness for filling is the main limitation of this study there are suggested actions of awareness from the health professionals, becoming evident the health responsibility, giventhe filling of notifications, and the promotion of preventive interventions in most vulnerable populations. Keywords: Poisoning; Public Health; Epidemiology ...

Characteristics of Cardiovascular Diseases of Hospital Patients Regional Em Garanhuns – PE

Research Article of Research Journal of Pharmacology and Pharmacy Characteristics of Cardiovascular Diseases of Hospital Patients Regional Em Garanhuns – PE Freitas JMM1, Pacheco ICO1, Lopes LGF2, Bezerra PB3 Specialization in Medical-Surgical Multidisciplinary Residency of the Internalization and Health Care, Federal University of Pernambuco (UFPE)1. Garanhuns – PE, Making Master’s Degree in Gerontology for the Federal University of Pernambuco /UFPE2. Making Master’s Degree in Child and Adolescent the Federal University of Pernambuco /UFPE3. To determine the profile of patients treated at the Regional Hospital of Garanhuns/PE affected by cardiovascular disease, check the socioeconomic condition, lifestyle and consumer atherogenic foods. A descriptive cross-sectional study, we assessed 42 patients aged 18 to 100 years. As a research tool used a questionnaire alimetar consumption, with questions about intake of foods rich in saturated fats, cholesterol and another to assess socioeconomic status, physical activity, alcohol consumption and smoking. Prevailed females 57.1 %, socioeconomic class type D 59.5 %. Sedentary lifestyle was present in 69 % of subjects, smoking 52.4 % and 26.2% alcohol. Foods high in cholesterol highlights a consumption frequency weekly as fatty meats 73.8 %. The findings demonstrate the need to strengthen health education in primary care. Keywords: Cardiovascular Diseases, Hospital Patients, Em Garanhuns – PE ...

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Research Journal of Pharmacology and Pharmacy

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Dr. B. Thangagiri
Assistant Professor (Senior Grade), Department of Chemistry, Mepco Schlenk Engineering College

Dr. Kaptain Kishor Bajpayee
Associate Professor & Head, Center for Research in Ethno & Medicobotany, Dr. R.M.L. Degree College (C.S.J.M. UNIVERSITY )Allipur, HARDOI 241001 INDIA.

Dr. Dhruba Pathak
The University of Tennessee Health Science Center, 855 Monroe Avenue, Suite 515, Memphis, TN 38163

Dr. Tauqeer Hussain Mallhi
School Of Pharmaceutical Sciences, Usm, Penang, Malaysia

Dr. Hamzah Maswadeh
Associate Prof. Head of Department of Pharmaceutics College of Pharmacy – Qassim University -KSA


Dr. Theophine Akunne
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria

Dr. Kasim S. Abass
Assistant Professor, College of Nursing, University of Kirkuk

Dr Yusra Habib Khan
University Sains Malaysia

Dr Charles Fokunang
Professor& Director of Student’ Affairs, The University of Bamenda; Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

Dr. Gelase Fredy Nsonde Ntandou
Faculty of Science and Technology, Marien NGOUABI University

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