Dermatological Research and Reviews

  • Management of Oro-Cutaneous Manifestations in Behçet disease and Recurrent Oral Aphthosis, review article

    Recurrent oral aphthosis is a major health problem affecting 20% of population. Its pathogenesis is not well elucidated, however, it’s considered as part of major criteria of Behçet disease. Many therapies advised to manage these ulcerations in both diseases and most of them are symptomatic, however, in the last decades; some of them have shown therapeutic as well as prophylactic roles. Herein, we review the different aspects of these therapies with emphasis on Iraqi experience.

  • The Effectiveness of Cream of Centella asiatica Ethanol Extract in Chitosan Nanoparticles Compared with Centella asiatica Ethanol Extract Cream, Silver Sulfadiazine Cream, and Control on Superficial Dermal Burn Healing in Rats

    Introduction: Centella asiatica extract is known to promote wound healing. Nowadays nanotechnology, especially nanoparticle is used to increase the bioavailability of active ingredients into the skin, one of which is chitosan nanoparticle. However, the effectiveness of Centella asiatica ethanol extract in chitosan nanoparticle (CAEECN) towards superficial dermal burn healing is not fully understood. Aim: To determine the effectiveness of CAEECN cream compared to Centella asiatica ethanol extract (CAEE) cream, silver sulfadiazine (SSD) cream and control in superficial dermis burn healing in Sprague-Dawley rats. Materials and Methods: A total of 20 male Sprague-Dawley rats were divided into 4 groups. After anesthetizing, 4 superficial dermis burns were made on the back of each rat and was given 4 treatments (CAEECN, CAEE, SSD, and control) afterward. Each group was sacrificed separately (respectively on day 3rd, 7th, 14th, and 21st post-burn induction). Several evaluations were macroscopic (wound size), and microscopic parameters (reepithelialization ratio and distance, wound contraction index, wound size, and angiogenesis). Results: There was no significant difference in wound size between treatments on day 0, 3, 7, 14, and 21. But three active agents (CAEECN, CAEE, and SSD) treated group showed early decrease of wound size compare to control group on day-3. Microscopically, there were no significant differences in reepithelialization ratio and distance, wound contraction index, wound size, angiogenesis. Nevertheless, CAEECN treated group showed the smallest wound size on day-3 and highest angiogenesis on day 21. Conclusion: Effectiveness of CAEECN in burn wound healing in rats showed no significant difference compared to CAEE, SSD, and control. But in three active agents (CAEECN, CAEE, and SSD) treated group, showed an early decrease of wound size compared to control group on day-3. Microscopically, CAEECN treated group showed the smallest wound size on day-3 and highest angiogenesis on day 21.

  • Volumeplasty of bulky nose using heat dermabrasion as a minor therapy

    Background: Ultrathick nasal skin and nodulation is one of the most daunting challenges in cosmetic nasal surgery. Rhinoplasty is a common surgical procedure to correct mostly gross abnormal nasal anatomical variation; however, many patients have minor bizarre shape or deformities that could not be well corrected by ordinary surgical procedures. So we should find other techniques to correct these unwanted or undesired nose shape abnormalities. Objective: The purpose of this article is to perform heat dermabrasion to reduce the size of bulky nose and to create new alar groove and to remove nose nodulations, acne or traumatic scarring. Patients and methods: In this study, we collected 40 patients with bulky nose during the period from 2009 through 2019; 21 females and 19 males and their ages ranged from 20-65 years. An Informed consent was taken from each patient before starting the study, after full explanation about the procedure. All patients had bulky nose, some had nodulation of nose and acne or traumatic scarring. Only one patient had history rhinophyma of several years duration. All patients were treated with heat dermabrasion using diathermy needle after local xylocaine anesthesia and patients were received topical antiseptic and oral antibiotics to be seen after 2 weeks. Then topical corticosteroid was used to prevent post-inflammatory pigmentation. Results:A total of 40 patients diagnosed with bulky nose were enrolled in this study; 21 (52.5%) patients were females and 19 (47.5%) were males. Age of patients ranged from 20-65 years with a mean of 42.5 years. The duration of the condition ranged from few months to several years. In all patients with bulky nose were improved and alar groove were created or maximized and gave satisfactory cosmetic results using heat dermabrasion. Post-inflammatory hyperpigmentation was noticed but overtime was gone. Conclusion: heat dermabrasion using diathermy is new simple innovative…

  • Trichotillomania is chronic obsessive compulsive disease with a diagnostic hair loss patterns

    Background: Trichotillomania (TTM) is a common cause of childhood alopecia. It’s a traumatic alopecia and is defined as the irresistible urge to pull out the hair, accompanied by a sense of relief after the hair has been plucked. The condition maybe episodic and the chronic type is difficult to treat. There seem to be an increase in the prevalence of the condition probably due to the changing life style into a more stressful one. Objective: To do full evaluation of this disease and description of hair loss patterns. Patients and methods: In this descriptive study, we collected patients with trichotillomania who had attended department of dermatology, college of medicine, university of Baghdad, Baghdad teaching hospital during the period from 2011 through 2019 where 114 cases of TTM were seen. The diagnosis was established on clinical basis after exclusion of other dermatological diseases and medical problems.Full history was taken from each patient including demographic data, presence of stressful life event as a triggering factor. Psycholgical assessment was carried out for each patient by experienced dermatologist as psychiatric referral was refused by all patients and their families.Full description of patterns of hair loss was carried out after exclusion of other causes of hair loss especially alopecia areata. Results: A total of 114 patients diagnosed with TTM were enrolled in this study,88 (77.19%) patients were females and 26 (22.8%) males with female to male ratio: 3.38:1 . Age of patients ranged from 6 – 65 years with a median age of 16 years with the commonest age range between 10-19 years in 64(56.14%) patients.While the duration of the condition ranged from 3 months to 4 years. Family history was positive in 6 (5.3%) patients, all of them were first degree relatives. Psychological evaluation showed obsessive compulsive neurosis in all patients and all patients…

  • FORMULATION AND EVALUATION OF WOUND HEALING ACTIVITY OF ALOE VERA LEAF EXTRACT ALONG WITH CURCUMA LONGA EXTRACT-BASED GEL

    Wounds result in functional disruption of living tissues. Herbs and their extracts have potential to regenerate damage skin. Purpose of this study was to evaluate the wound healing activity of aloe vera leaf extract in combination with curcuma longa extract. Both herbs possess anti-inflammatory and antibacterial properties. Gel-I and Gel-II were formulated using Carbopol 940, 3%w/w aloe vera leaf extract, 1 and 3%w/w curcuma longa extracts respectively and were applied on excision and incision wounds created on albino rabbits. Animals were divided into four groups having six animals, group-I was control, group-II received standard gel (Nitrofurazone), group-III received Gel-I, group-IV received Gel-II. Gels were evaluated for color, pH, clarity, viscosity, consistency, spreadability, extrudability, skin irritation test and stability studies. Gels were applied on excision wound once a day for 12 days. Wound treated with Gel-II showed better healing activity and greater percentage of wound contraction (p

  • Epidemiological Profile of Leprosy from 2006 to 2013 in Limoeiro, Pernambuco

    Introduction: In the epidemiological transition experienced by Brazil, the prevalence of infectious-contagious diseases is still evident. Among them, leprosy is a public health problem whose main etiological agent is Mycobacterium leprae. It is a common pathology in developing countries. Methodology: Descriptive and retrospective study, with data collection from 2006 to 2013, coming from the National System of Information of Notifiable Diseases (SINAN). Results: 93 cases of leprosy were reported in the period covered by the data search. Resulting in an average detection of 1.5 cases / 10,000 inhabitants / year. According to the analysis of the data obtained, there was a predominance of male cases (51.61%), urban residents (60.22%), age range from 30 to 39 years (23.66%), as Dimorfa being the most reported Clinical Form (39.78%). Conclusions / Considerations: It is expected that new strategies and actions will be implemented, or revised, as more specific measures for the prevention and control of leprosy in the municipality of Limoeiro, Pernambuco.

  • Histomorphometric Analysis Of Reepitelization And Collagen Matrix Of Cutaneous Wounds Treated With Hydroalcoolic Extract From The Leaves Of Conocarpus Erectus Linnaeus

    Introduction: The species Conocarpus erectus Linnaeus belonging to the Combretaceae Family, that contains 18 genera, where the genus Combretum is considered to be the largest distributed on the whole African continent, possessing about 370 species that are abundantly used in folk medicine due to its chemical diversity, its low toxicity and low cost. The species of this family are widely used as a therapeutic resource for various types of pains, colds, diarrhea, conjunctivitis, pneumonia, mumps, cancer, hypertension, infections and wound treatment. The wound healing is a process that involves the performance of several cell types, extracellular matrix and chemical mediators, in order to promote tissue reconstitution. Objective: To evaluate reepithelialization and collagen deposition through the histomorphometry of the scar tissue treated with the hydroalcoholic extract of the leaves of Conocarpus erectus Linnaeus. Methodology: For the general outline of the experiment, male Wistar rats (200-250 g) were randomly divided into four groups: Group I (Negative Control – Lanette Cream); Group II (10% FHFCS – Cream formulation of the hydroalcoholic extract of dry leaves C. erectus); Group III (Cream formulation of the hydroalcoholic extract of fresh leaves of C. erectus) and Group IV (Dexpanthenol – Standard). Each group was subdivided into four subgroups with five animals for euthanasia on the 7th and 21st day. The animals were previously anesthetized with a combination of ketamine and xylazine and were later placed in a ventral decubitus for manual trichotomy and antisepsis with 0.1% iodized alcohol, the area of incidence was marked using a metal punch with a cutting blade (± 10 mm²). Then, the treatments were started and a new layer (± 95 mg) was applied daily. Histological preparations were submitted to Hematoxylin-Eosin technique. The histological images were captured by a digital camera coupled to an optical microscope, obtaining 06 fields per slide with…

  • Histomorphometric Evaluation Of The Effect Of Semi-Solid Formulation Of Conocarpus Erectus Leaves On Fibroblasts And Inflammatory Cells In The Process Of Tissue Remodeling

    Introduction: The wound can be defined as a skin lesion caused by chemical, physical or biological factors leading to cutaneous discontinuity. Based on the healing process, the evolution of the wounds can be mentioned as acute and chronic. Healing is the tissue repair process coordinated by biochemical and histological factors to restore tissue integrity. Since ancient times, medicinal plants have been used as a therapeutic resource, contributing to the treatment and prevention of various diseases. The species Conocarpus erectus Linnaeus, popularly known as “mangue de botão”, is found in the mangrove and stands out for presenting analgesic, anticancer, antimicrobial and hepatoprotective properties. Objective: Evaluate the ability of semi-solid formulations of C. erectus leaves through the histomorphometry of fibroblasts and inflammatory cells in the tissue remodeling process of cutaneous wounds in Wistar rats. Methodology: For the evaluation of the cicatrizant activity were obtained formulations containing 10% of the hydroalcoholic extract of the dry and fresh leaves of C. erectus (FHFCS and FHFCF 10%, respectively), manipulated within the standards and quality control for medicaments in the Laboratory of Pharmacotoxicological Prospecting of Bioactive Products of Universidade Federal de Pernambuco. To evaluate the healing activity, excisional cutaneous wounds were surgically made in the dorsal midline of the cervical region of Wistar rats (n = 5), these were standardized (6 mm²) and performed with animals previously anesthetized, after tricotomy and adequate antisepsis. Then, the wounds were treated with daily topical application (± 95 mg) of the preparations according to the experimental design: Group I (Negative Control – Lanette Cream); Group II (10% FHFCS); Group III (10% FHFCF); Group IV (Dexpanthenol – Positive Control) for 14 days. The histological preparations were submitted to a staining technique by Hematoxylin-Eosin (H.E.) for counting inflammatory cells and fibroblasts. The histological images were captured by digital camera coupled to the…

  • Face Powders: Formulation Considerations

    The face powder was demanded by many nations in the world in the beginning AD and in Asia white skin was believed to be the sign of aristocratism, membership of the elite, and yet, white color is the pure symbol of the internal beauty and nobility. In addition, some face powders are sold in varying specialty shades to suit different skin needs; for example, a face powder with a greenish tinge will minimize the appearance of redness, while a purple-tinted powder may help the appearance of sallow or yellow skin. There is a legitimate reason to use face powder, and the pharmacopeias prescribe them in the treatment of many skin affections. At all events the proper use of powder is beneficial, it lightly covers and unifies a complexion, hiding the ravages of time, improving even the beautiful face. Face powder comes in different shades to match varying skin tones, and it is a good idea to choose the skin tone that most closely matches the natural skin. This will help the makeup appear more natural; it should be virtually unnoticeable. It may be necessary to use different face powders for summer and winter, as the skin may become tanner in the summer, or drier and in need of extra moisture in the winter. They are of benefit in acne, freckles, sunburn and red nose. Beneath their attractive aspect and odor, face powders should be made by the perfumer to combine the qualities of an elegant cosmetic and therapeutic agent; they must primarily possess adherence, lightness and be transparent; secondly, they should be detergent and delicately absorbent in order to aid the natural functions of the skin, taking up the fatty matters not easily dislodged by water; they should also tend to increase the natural elasticity and regular functions of the…

  • Urbanization, Environmental Pollution & Skin Aging

    The skin aging process, which is prompted by environmental variables, is named untimely or extrinsic skin aging process and can be recognized from the sequentially (intrinsic) skin aging process by trademark skin aging signs. Albeit human skin goes about as a biological shield against pro-oxidative chemicals and physical air pollutants, prolonged or tedious presentation to abnormal amounts of these pollutants may have profound negative impacts on the skin. Sexual orientation contrasts in toxicity have been accounted for some substances. Youngsters are known to be increasingly defenseless against the antagonistic health impacts of air pollution. Environmental pollution by traffic is additionally connected with the event of indications of extrinsic skin aging. Heavy metals, for example, cadmium, lead and mercury are regular air pollutants that posture health hazards because of bioaccumulation. Ozone in the stratosphere has protective impacts by sifting solar UVR; be that as it may, in the troposphere ozone has toxic implications for skin. Because of scarcity of logical proof, there are no settled rules as of now accessible for protecting the skin against air pollution. Beside lessening presentation, potential protection techniques should concentrate on fixing the skin barrier, renewing antioxidant save, and diminishing inflammation brought about via air pollutants.