Merkel cell polyomavirus on primary Merkel cell carcinoma of the skin with partial regression after biopsy
Introduction: Merkel cell carcinoma (MCC) is an uncommon primary cutaneous tumour. The majority of these tumour (about 80%) have integration of the polyomavirus DNA into the genome of Merkel cell carcinoma. Reports about at least nine cases of partial regression in primary and or metastatic lesions have been published. It is likely that regression is an immunological response mediated by T cells. Case Report: We report an 81year old woman who presented with a rapidly growing tumor in the left thigh. An incisional biopsy of the lesion was performed. Histopathologic and immunohistochemically diagnosis were consistent with Merkel cell carcinoma. Scant peritumoral lymphocytic infiltrate was CD3+, CD4+, and scant CD8+ was observed. The reporter test polymerase chain reaction (PCR) for Merkel virus yielded a positive result. Twenty days after the initial biopsy the lesion began to regress. Conclusion: Merkel cell carcinoma is a rare and aggressive tumour. At least nine cases of partial regression on primary and or metastatic lesions have been published. It is likely that regression is a T cell-mediated immunological response. A reporter test (PCR) for Merkel virus and both types of lymphocytic infiltrate and distribution (intratumoral and peritumoral) in our case very important as there are several known mechanisms that can contribute to cellular immune escape in MCP y V positive Merkel cell carcinoma. Study of integration and regulation of the immunological system implies future development of individually of different immunological therapies.
Individualized approach for Coarctation of the Aorta in a Patient with PHACE syndrome and Extensive Hemangiomas
PHACE syndrome is a neurocutaneous disorder with large facial segmental hemangiomas associated with anomalies of the brain, eye and heart. We report a case of a 3 years old girl who presented at the age of 6 weeks with severe coarctation of the aorta and aortic arch aneurysm. In addition, she had extensive strawberry hemangiomas over the scalp, neck and chest which, after extensive investigation, led to the diagnosis of PHACE syndrome. After complete evaluation we successfully initiated treatment with propranolol that was pursued without complications over three years with striking success and remarkable regression of her hemangiomas. Meanwhile the coarctation was managed conservatively. This case highlights that propranolol treatment, while effective against hemangiomas, may contribute to slow the progression of aortic arch aneurysm and delay the need for high risk surgical intervention.
Surgical Correction of Intra-Areolar Polythelia
Intra-areolar polythelia (IAP) is an extremely rare congenital malformation with the presence of two or more nipples within a normal sized areola. This is a case report of a 25-year-old gentleman who presented with two nipples on the areola of his left breast since birth. Surgical excision was done under local anesthesia for aesthetic purpose.
THE COEXISTENCE OF A PRE-AURICULAR SINUS WITH POST-AURICULAR DERMOID CYST
A pre-auricular sinus will rarely present in coexistence with a post-auricular dermoid cyst. The coexistence of a discharging pre-auricular sinus with a post-auricular dermoid cyst presents a diagnostic challenge. Without meticulous history taking and physical exam, one would subject the patient to aggressive and unwarranted investigation and management modalities as though the infected post-auricular dermoid cyst were a mastoid abscess. We present a 15-year-old male who presented to the ENT clinic of Mulago National Referral Hospital and was diagnosed with an infected pre-auricular sinus with an infected post-auricular dermoid cyst.
Assessment the effect of the use of bisphosphonates on dental implant rehabilitation and peri-implant tissues
Background: Long-term use of bisphosphonates (BP) has been associated with the risk of BP-related osteonecrosis of the jaw (BRONJ). The number of post-menopausal women receiving BP therapy for osteoporosis continues to increase as the life expectancy increases. Dental implant rehabilitations have progressed over the years. The purpose of the present study was to evaluate the peri-implant conditions of patients taking oral or intravenous (IV) BPs. Methods: This was a retrospective study using an ORACLE database search by means of a Procedural Language/Structured Query engine. Fifty female patients with dental implant rehabilitations and taking bisphosphonates, and fifty female patients with dental implants but not taking BP were evaluated. Peri-implant health and rehabilitation conditions were collected and statistics analyzed. Results: Data analysis revealed a strong indication (p
The effect of Import Solid Waste Ban on China’s Economy and Environment based on Grey Prediction Model
In order to explore the impact of imported solid waste ban on China’s economy and environment, a grey prediction model was established in this paper. GDP, comprehensive income from the utilization of waste resources, the number of imported solid waste treatment enterprises, and the discharge of polluting waste gas and waste water were selected as the indicators to measure the economy and environment. The model was used to predict the data of the unreal garbage ban and compare it with the data after the actual implementation, and get the proportion of the impact on China’s economy and environment after the introduction of the policy. The results showed that before and after the promulgation of the ban on foreign waste, China’s environmental pollution had improved significantly, the total exhaust gas emissions have been reduced by 34.1%, and the number of imported waste enterprises had decreased by 66.1%, stimulating the rise of the domestic waste utilization industry, and the overall domestic economy had grown steadily.
PAST, PRESENT AND FUTURE OF REMDESIVIR—OVERVIEW OF A MOST POPULAR ANTIVIRAL IN RECENT TIMES
Recent international epidemics of coronavirus-associated illnesses underscore the urgent medical and public health need for vaccine development and regulatory body approved therapies. In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human life. Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. Currently available evidence about the antiviral effects of remdesivir against to accumulate before the clinical trials are concluded. It is imperative for public health practitioners and the One Health community to stay up to date on the most promising potential therapeutic options that are under investigation. Thus, the purpose of this review is to synthesize the knowledge to date about remdesivir as a therapeutic option for coronaviruses, with a special focus on information relevant to the One Health community
RETRACING RATIONALITY FOR COVID -19 – A UNION THERAPY INITIATIVE
Rationality is not a phenomena restricted to drugs It is also included in behavioral, psychological mythological spiritual and religious elements. Every aspect of health as per WHO health definition affects the treatment process of illness to restore health. This review is based on rationality as per the union therapy concept/ Sayojyachikitsa which aims to integrate various aspects of rationality and aims to integrate supernatural mythological and scientific aspects of rationality and devised 15 R to make treatment comprehensively holistic. This would make therapy accessible acceptable on global scale. This would help to use drugs in COVID -19 threat where in addition to clinical elements behavioral, psychological mythological spiritual and religious elements of rational drug use can play a vital role.
CT Image Reconstruction Method Based on Filtered Back Projection Algorithm
This paper used the relevant knowledge of electronic computer tomography image reconstruction to solve the problem of CT system parameter calibration and imaging algorithm. Through geometric analysis, a target optimization model was established. The parallel beam filtering back-projection algorithm was used to solve the problem based on the information received by the detector unit. The image reconstruction model was used to obtain the position information of the medium. Finally, image stability was verified by noise processing.
Analysis of Solvent Effect on Formation Constants and Speciation of Cobalt(II), Copper(II) and Lead(II) Complexes of L-Methionine and Uracil
The analysis of coordination of chelating agents to metal ions in the formation of complexes under different experimental conditions provide information on the effects of the conditions on the extent of the coordination of the ligands to the metal ions for potential applications in bioinorganic and environmental Inorganic Chemistry. The effect of solvent on the coordination of L-methionine (primary ligand) and uracil (secondary ligand) to Co(II), Cu(II) and Pb(II) ions in the formation of binary and ternary complexes have been potentiometrically investigated in water and 40% (v/v) ethanol- water media at 27 °C and ionic strength of 0.02 mol dm–3was maintained by using NaNO3. The proton-ligand stability constants and formation constants of the binary and ternary systems were established under the experimental conditions. The formation constants of the ternary complexes were numerically compared with the corresponding binary complexes in terms of Δ log K and percentage relative stabilization (%RS). Speciation of the metal ions, binary and ternary complexes as a function of pH in the solutions was investigated by using HYSS program. The ligands were observed to form more stable ternary complexes than binary complexes. The proton-ligand stability constants the ligands and the formation constants of the metal complexes were found to be higher in 40% (v/v) ethanol-water than water. The distribution of the species revealed a decrease in the metal ion concentrations with increase in the concentrations of the binary and ternary as pH increased. The chelating agents interacted strongly with the metal ions and showed different selectivity towards the metals ions. These properties can be exploited in combating metal poisoning, separating the metals and expounding the bioinorganic chemistry of the metal ions and the ligands.
