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Journal of Pharmaceutical Research and Reviews

Pharmaceutical Research and Reviews, Recent Articles

ANTI-CANCER ACTIVITY OF QUERCETIN VIA APOPTOSIS INDUCTION PATHWAYS IN HUMAN BREAST CANCER CELL LINES-A SYSTEMATIC REVIEW AND META-ANALYSIS

Review Article of Journal of Pharmaceutical Research and Reviews ANTI-CANCER ACTIVITY OF QUERCETIN VIA APOPTOSIS INDUCTION PATHWAYS IN HUMAN BREAST CANCER CELL LINES-A SYSTEMATIC REVIEW AND META-ANALYSIS Rawdha Benziane; Bunmi Ibrahim* School of Allied Health Sciences. De Montfort University, Leicester. United Kingdom A systematic review and meta-analysis were conducted to summarize and review the current literature surrounding quercetin in breast cancer and evaluate its efficacy as an anticancer agent in human breast cancer cell lines. Electronic databases, PUBMED, WEB OF SCIENCE and MEDLINE were systematically searched in December 2020 using the key terms, Quercetin AND Breast cancer AND apoptosis OR cell cycle. Fourteen papers surrounding effects of quercetin on cell viability were obtained. Risk of bias assessment revealed that most papers were reliable. Three meta-analyses were conducted to confirm the efficacy of quercetin at the concentrations of 40-50 µM, 100µM, and >100µM (120- 200 µM). Two subgroup analyses on incubation time and cell type were performed to ascertain whether these factors affect mechanisms of quercetin. Results showed that the decrease in percentage cell viability is directly proportional to increasing concentration. The greatest decrease in cell viability was observed in 100 µM (Risk Ratio (RR) = 0.56; p<0.00001), followed by 100 µM (RR= 0.74) and then 40-50 µM (RR=0.79). However, effects of quercetin may be determined by other factors such as incubation time or a particular cell type signaling cascade. Subgroup analysis revealed that significant differences between 24 and 48 hours were not observed. MCF7 cells showed to be most sensitive to actions of quercetin (p< 0.0001). It was concluded that there is enough information surrounding the cytotoxic effects of quercetin to be progressed forward, however optimal doses that are physiologically relevant and safe in humans should be elucidated. Keywords: quercetin, breast cancer cells, apoptosis, meta-analysis, systematic review, cell viability ...
Pharmaceutical Research and Reviews, Recent Articles

PHARMACEUTICAL ATTENTION IN THE CELIAC DISEASE: SAMPLINGS IN THE CITY OF FOZ DO IGUAÇU/PR

Research Article of Journal of Pharmaceutical Research and Reviews PHARMACEUTICAL ATTENTION IN THE CELIAC DISEASE: SAMPLINGS IN THE CITY OF FOZ DO IGUAÇU/PR Rafaela Dal Piva1*, Jociele Tonin Volkweis1, Thaís Tonin1 1CESUFOZ Objective: To analyze the difficulty found in the diagnosis of celiac disease; the identification of patients’ knowledge about the pathology; Self-medication to treat the symptoms before the disease is detected; the significance of the pharmaceutical care to the celiac patients, among others related problems. Methods: Biographical survey and gathering of data encompassing the sampling of individuals of Foz do Iguaçu, members of the local celiac society. Due to the COVID-19 pandemic, the interviews occurred by electronic contact, trough “Google Forms”. This work had its project submitted to the Research Ethics Committee of UNIOESTE, approved on August 7, 2020 in all of its terms and proposals, with opinion n. 4.198.688. Results: It was found that, of the 180 interviewed, 56.7% of all the carriers made used self-medication. And 41, 1% of all patients reported that the necessary time for the disease diagnosis was 1 to 5 years. Among the most common symptoms was abdominal swelling with 94,4% incidence, cramps with 60,6% and flatulence with 76,1%. Another important factor to be considered is that 87,8% reported to have the pathology under study, due to genetic predisposition. Conclusion: Such responses prove the importance of the pharmaceutical professional to identify the pathology and guide about which conduct must be followed by the patient, as well how to guide them on the possible presence of gluten in some medications, aiming to avoid self-medication, abuse of drugs that can aggravate the symptoms and a greater incentive to clinical knowledge in order to obtain an early diagnosis. Keywords: Celiac Disease. Self-medication. Gluten. Pharmaceutical Attention ...
Pharmaceutical Research and Reviews, Recent Articles

Terpenoids and steroids isolated from Calophyllum polyanthum

Research Article of Journal of Pharmaceutical Research and Reviews Terpenoids and steroids isolated from Calophyllum polyanthum CAO Ting-ting1, LI Xu1, YANG Teng-yun2*, LI Dan-dan3* 1School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming 650500, Yunnan, PR. China. 2Department of Sports Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR. China. 3The First Affiliated Hospital of Dali University, Dali 671000, Yunnan, PR. China. Three triterpenoids, one diterpenoid and two steroids were isolated from the aerial parts of Calophyllum polyathum. The structures of these compounds were determined by 1D NMR and mass spectroscopic data. Among them, compounds 1, 3, and 4 was obtained for the first time from Calophyllum polyathum. Keywords: Calophyllum polyathum; Guttiferae; Terpenoid; Steroid; Structure elucidation ...
Pharmaceutical Research and Reviews, Recent Articles

PAST, PRESENT AND FUTURE OF REMDESIVIR—OVERVIEW OF A MOST POPULAR ANTIVIRAL IN RECENT TIMES

Review Article of Journal of Pharmaceutical Research and Reviews PAST, PRESENT AND FUTURE OF REMDESIVIR—OVERVIEW OF A MOST POPULAR ANTIVIRAL IN RECENT TIMES DWAIPAYAN SARATHI CHAKRABORTY*, SHOUVIK CHOUDHURY REGISTRAR, DEPARTMENT OF CARDIOLOGY, BELLE VUE CLINIC Recent international epidemics of coronavirus-associated illnesses underscore the urgent medical and public health need for vaccine development and regulatory body approved therapies. In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human life. Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. Currently available evidence about the antiviral effects of remdesivir against to accumulate before the clinical trials are concluded. It is imperative for public health practitioners and the One Health community to stay up to date on the most promising potential therapeutic options that are under investigation. Thus, the purpose of this review is to synthesize the knowledge to date about remdesivir as a therapeutic option for coronaviruses, with a special focus on information relevant to the One Health community Keywords: REMDESIVIR, COVID-19, Review ...

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Journal of Pharmaceutical Research and Reviews

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