Research Journal of Pharmacology and Pharmacy

Research Article of Research Journal of Pharmacology and Pharmacy Osteosarcoma’s STAT-3 Vrs Kaempferia parviflora’s Compounds : Possible Drug Candidates Chandra Sekhar Tripathy1, Anil Kumar2, Santosh Kumar Panda3, Santosh Kumar Behera4, Gaurav Giri5, Asadollah Asadi6, Santanu Kumar Budhia7, Arash Abdolmaleki8, Easter Khura9, P K Mohanta10, Muhammad Akram11, Deepak Bhattacharya12* 1M.Sc., Regional Medical Research Centre, Bhubaneswar, Odisha, India; 2Principal Scientist & Head, Division of Design of Experiments I.C.A.R-I.A.S.R.I., Library Avenue, New Delhi, India, PIN- 110012; 3 MS, ENT Surgeon, Capital Hospital; Govt., Bhubaneswar, Odisa, India; 4Ph.D., Scientist Grade II, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat,India; 5BAMS,  Govt Drug Inspector, AYUSH, Govt of Odisha, Bhubaneswar, India; 6Associate Professor, Department of Biology, University of Mohaghegh Ardabili,  Iran; 7BA; Traditional Ayurvedacharya, Nagharen Temple Rd, Baabajee Padaa, Balangir, Odisha,India PIN – 767025; 8Assistant Professor, Animal Physiology, University of Mohaghegh Ardabili, Faculty of Advanced Technologies. Department of Biology; 9M Sc (nursing), Vice Principal, School of Nursing, Raxaul, Bihar, India – 845305; 10MD (Ay), Govt Drug Inspector; Registrar Ay Council; Principal. IGMMC & Hospital, H-2/58,SS Enclave,Khandagiri,Bhubaneswar-751030, Odisha; 11BEMS, M.Phil, Ph.D, Chairperson, Dept. of Eastern Medicine, Government Collage University, Faisalabad, Pakistan; 12Ph.D., Policy, Nursing, At Fight-Cancer at Home, Medicinal Toxicology & QC, At : Sri Radha Krishna Raas Mandir, KedarGouri Road, Bhubaneswar–751002, Odisa, India. Osteosarcoma is a dominant type of bone cancer, associated with osteophytes (bone cells). Afflicts all age groups; generally manifesting in long bones of human physiology(also other parts; including fine joints). Chemotherapy, surgery and radiation are the current therapeutics – with uncertain results; often associated with high degree of failure; swift relapse; rebound aggression and above all with debilitating post treatment out come conditions. In this investigation in silico drug designing procedures have been used to predict natural compounds from Kaempferia parviflora (black ginger) as possible drug candidates for osteosarcoma. 8 of its phyto-compounds (PCs) ...

Review Article of Research Journal of Pharmacology and Pharmacy Antiparasitary Activity Of The Juglone Compound: A Narrative Review Paulo Henrique Valença Nunes1,2*, José Rafael da Silva Araújo2, Victor Hugo Barbosa dos Santos1,2, Renan Andrade Fernandes de Souza1,2, André de Lima Aires1,2, Mônica Camelo Pessoa de Azevedo Albuquerque1,2 1Laboratorio de Imunopatologia Keizo Asami; 2Universidade Federal de Pernambuco; Objective: To report, based on the literature, the action of the compound 5-hydroxy-1,4-naphthoquinone against parasites (protozoa and helminths) that affect humans. Methods: This is a narrative review that used Pubmed and Google Scholar as a data tool. This work included articles published until September 2020 that were directly related to the use of the compound juglone in antiparasitic trials. Results: The compound juglone demonstrated promising effects as a human and animal antiparasitic substance. In protozoa, the Apicomplexo Toxoplasma gondii parasite showed a high mortality rate in concentrations of juglone in the nanomolar range. The juglone showed an average inhibitory concentration (IC50) of 1.62 µM, >100 µM, and 2.02 µM µM for Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani, respectively. Also, the juglone showed antihelmintic activity on Hymenolepis nana in mice, and on adult worms of Schistosoma mansoni (LE strain) with IC50 34.16 µM, 32.14 µM, and 25 µM in the 24h, 48h, and 72 h, respectively. Conclusion: The results published so far show the in vitro antiparasitic potential of juglone, and the need for further studies on the specific mode of action that interacts with parasites. Besides, the literature is still limited to studies that evaluate in vivo the compound juglone, requiring better information on its interaction with living organisms. Keywords: natural compounds, antirapasite, pharmacology activity ...

Research Article of Research Journal of Pharmacology and Pharmacy A TRIGA-like subcritical concept for biological waste management (pills, old vaccines etc.) Florent Pirot Independent researcher This subcritical concept is framed in a way that allows use in a single room for some electricity production purposes. It involves a tungsten casing and also helps using depleted uranium dust. The single series of anneals for closure and direct laying of the top opening window onto the left side of the tungsten casing make pressure work impossible ; it also allows for a relatively cheap production. Keywords: TRIGA-like subcritical concept; biological waste management ...

Research Article of Research Journal of Pharmacology and Pharmacy Alpha-emitting nanoparticles and the Warburg Effect, skin diseases, eating disorders, musculoskeletal disorders, alcoholism, cigarette, hypersexuality and neurofibromatosis type 1 Florent Pirot Independent researcher Alpha emitting nanoparticulates in internal contamination, an IARC Class 1 carcinogen, have an extremely wide list of effects. New effects are here demonstrated based on a wide epidemiological survey. WHO data in particular is used together with other large sets and juxtaposed to known sources of variations of radioactivity contamination in the environment to demonstrate the link which is always explained by the strong decay energy and its impact on the organism. Some behaviours are shown to be strategies of pain reduction, others of decontamination. This article confirms the simple logic of biophysics (the linear-no-threshold model) outlined by the author in previous publications. Keywords: Alpha-emitting nanoparticles; the Warburg Effect; skin diseases; eating disorders; musculoskeletal disorders; alcoholism; cigarette; hypersexuality; Multiple sclerosis; rheumatoid arthritis; neurofibromatosis ...