Recent Articles

Treatment for Chronic myeloid leukemia has been revolutionized because of availability of different tyrosine kinase inhibitors. Each TKI come with its on toxicity profile as this needs to be taken in account before starting therapy with particular agent in a patient. Most of the adverse effects related to TKI are mild and can be managed by either symptomatic treatment or either by dose reduction. But some patients can become intolerant and to switch to other TKI remains the only option. Bosutinib is currently approved for treatment of chronic phase CML in patients who are either resistant or intolerant to previous TKI. We present a case of 59 year old male patient with CML who was intolerant to Dastanib and Nilotinib but showed excellent hematological and major molecular response to bosutinib

Cornual pregnancy is a fearful condition with dreadful complications. Due to rarity and late presentation, it poses diagnostic and therapeutic challenges. There is no consensus on treatment strategies till date and risk of rupture after repair in subsequent pregnancy always remains a major concern. We hereby discuss a case of 27 year female who presented with ruptured cornual ectopic pregnancy, underwent cornual wedge resection with repair and had subsequent pregnancy with a successful outcome.

Ibn Qutayba (828-889) is one of the most important writers of medieval Arabic literature. He is the author of several books of Adab, a classic genre of prose cultivated among the Arabs in the Middle Ages. This paper refers to this outstanding figure of medieval times and is an approach to the study of one of his main works: the compendium of Adab (belles-lettres) entitled as ‘Uyūn al-Akhbār (Sources of information). It includes some preliminary notes by way of introduction about the life and the work of the author, a special reference to the cited book, and an appendix with the English translation of an Arabic text selected and taken from the ‘Uyūn al-Akhbār.

Introduction: The role of the clinical pharmacist in the management of acute pancreatitis has not been researched extensively, and only a few published studies on the topic can be found. This clinical review presents all pertinent published data and serves as a guide for clinical pharmacists who participate in the management of patients with acute pancreatitis. Methods: An extensive literature search was conducted on PubMed from 1990 to 2021 to retrieve relevant studies focusing on the role of the clinical pharmacist in the treatment of acute pancreatitis. Results: An analysis of the medications that are associated with acute pancreatitis is presented, highlighting the responsibility of the pharmacist to conduct a thorough medication investigation in order to identify a possible drug-induced acute pancreatitis. Medical management of acute pancreatitis, mainly fluid therapy, is an area where a clinical pharmacist can appropriately intervene. Proper choice of fluid therapy and its rate, nutritional considerations, pain management and antibiotic use, are all important to consider for a successful treatment with minimal adverse effects. It is well documented in the literature that clinical pharmacists can decrease hospital costs. Discharge counseling performed by a clinical pharmacist has been shown to increase patient compliance and decrease both readmission rates and follow-up physician visits. Conclusion: The clinical pharmacist, as the primary drug expert, can identify medication-induced pancreatitis, diminish the use of unnecessary antibiotics, improve patient care and decrease the overall costs.

Background; S100B has been shown to be beneficial as a biomarker in the treatment of adults with mild traumatic brain injury (mTBI). The efficacy of S100B as a biomarker in children, on the other hand, has been a subject of debate. Aim and objectives; was to assess the validity of Protein S 100B in Mild Pediatric Head trauma. Subjects and methods; this was a prospective study, included 160 pediatric patients with mild head trauma presented to Emergency Department. Result; A highly significant correlation between Positive S100B protein and traumatic brain injury with S100B protein value 1554.1±84.0 ng/L. A100 had cutoff value for positive CT Brain finding above 987.5 ng/L, The sensitivity was 81.0%, the specificity was 75%%, the NPV was 86%, the PPV was 68%, and overall accuracy 77%. There was none statistical significant difference regarding severity of brain injury and S100 B (P = 0.225), Conclusion; Serum S100B levels cannot be used to substitute clinical examinations or CT scans in identifying pediatric patients with mild head injuries, but they can be used to identify low-risk kids to avoid excessive radiation exposure.

The prevalence of gastrointestinal and urinary tract parasites among students of Isaac Jasper Boro College of Education (IJBCOE), Bayelsa State was investiagted. Faecal and urine samples were collected from 273 presumably healthy students of the college. The samples were analyzed in the laboratory using sedimentation method for urine and formol-ether concentration method for the stool samples. A self-structured questionnaire was used to obtain some risk factors associated with the transmission of the parasites. Out of the 273 students investigated, 60 (22.0%), 31(11.4%) and 12(4.4%) were positive for gastrointestinal parasites, urinary tract parasites and coinfection of gastrointestinal and urinary tract parasites respectively. Entamoeba histolytica recorded the highest prevalence among the gastrointestinal parasites identified (62%), followed by Entamoeba coli (18.3%), Giardia lamblia (11.7%), Blastccytis homonis (5%), and Enterobius vermicularis (3.3%). Among the two urinary tract parasites identified, Trichomonas vaginalis was more prevalent (90.3%) while Schistosoma haematobium had 9.7%. More Female students (37.8%) were infected than males (25.7%) by gastrointestinal parasites. The age range prevalence for gastrointestinal parasites recorded 45%, 37.3%, 28.3% and 25% for 26 – 30 years, 16 – 20 years, 21 – 25 years, and 31 – 35 years respectively. Lack of awareness, consumption of faecal matter-contaminated food and water, poor sanitation, defaecation into drinking water sources were identified as risk factors for gastrointestinal parasites while engagement in unprotected sex and multiple sexual partners were recorded as risk factors for the transmission of Trichomonas vaginalis. Increased personal hygiene and sanitation, provision of toilet facilities and health education will mitigate the prevalence of the parasites in the study area.

For some individuals, trading can become a problematic activity and be considered a gambling disorder due to its adverse consequences. Because few studies have been conducted to date investigating this issue, the aim of this study is to improve knowledge on this topic by presenting a case study of a participant playing the stock market. A research interview was conducted, transcribed, and analyzed using Alceste®. This case study revealed three classes of meaning: the role of family in trading behavior; trading history, motives, and beliefs; and the tilt. Results shed light on the link between gambling and trading activities, and tend to support the existence of a trading behavior resembling addiction, which may be more significant when trading with high-risk derivative products due to their unique characteristics.

Pulmonary embolism occurs when thrombi enter the pulmonary arterial circulation. Most pulmonary embolisms are the result of deep venous thrombosis of the pelvic limbs, chest or pelvis, and, less commonly, the jugular veins or inferior vena cava. Venous thromboembolism includes deep vein thrombosis and pulmonary embolism. It is the third most common cardiovascular disease, with a total annual incidence of 100-200 per 100 000 population. INTRODUCTION: Acute pulmonary embolism is the most serious clinical presentation of venous thromboembolism. Overall, pulmonary embolism is a major cause of mortality, morbidity and hospitalization. Mortality in pulmonary embolism depends on haemodynamic impairment, age and co morbidities. The prognosis of patients with pulmonary embolism depends on two factors : underlying disease state plus diagnosis, and appropriate treatment. Approximately 10% of patients who develop pulmonary embolism die within the first hour, and 30% subsequently die of recurrent embolism. CASE PRESENTATION: In this presentation we present the case of a 49-year-old male patient without co morbidities, presented repeatedly to the Emergency Room for symptoms suggestive of pulmonary thromboembolism, who benefited from life-saving therapies due to timely diagnosis and appropriate treatment, with subsequent favorable outcome. CONCLUSIONS: The particularity of the case is that, on the one hand, the thromboembolic event recurred in a short time, on the other hand, the evolution was favorable in both cases, with complete recovery of right ventricular function and disappearance of pulmonary hypertension, despite the fact that the patient was non-compliant with initial anticoagulation therapy. This was due to both early diagnosis and timely administration of appropriate treatment.

Zygomycosis occurs primarily in immunosuppressed patients and those with diabetes mellitus. Incidence of zygomycosis has increased among transplant recipients, patients with hematologic malignancy and Covid-19 associated pulmonary complications. Soft tissue zygomycosis may be localized, extend to deep underlying tissues, or may be disseminated. The most common clinical presentation is induration of the skin with surrounding erythema, rapidly progressing to necrosis.Histological examination and culture of soft tissue are important for the diagnosis of cutaneous zygomycosis. Treatment consists of surgical excision or debridement, reversal of predisposing factors and administration of antifungal agents (amphotericin B formulations, Posaconazole/or Isavuconazole).

Microtia- Anotia (M-A) is a rare congenital malformation of the external ear structure commonly associated with atresia or stenosis of the ear canal. Its prevalence is more common in Asians and Hispanics, is generally unilateral and is seen more commonly in males. It can either be an isolated defect or be a part of specific pattern of anomalies involving other organs. It has been documented as a component of either a teratogenic embryopathy (isotretinoin, thalidomide or alcohol) or single gene disorders like Treacher Collins and as a part of a pattern of multiple defects like Goldenhar, Nager and CHARGE syndrome. We report a case of a newborn with bilateral microtia-anotia and facial palsy, who on further evaluation was found to have congenital heart disease also. The triad of anotia, facial paralysis and cardiac anomaly is rare and has been first described by Pearl in 1984.Thus, the obviously visible ear malformation at birth should be evaluated in depth to rule out other underlying malformations.