International Journal of Aging Research


Incidence of Cognitive Decline and Association with Changes in Sociodemographic, Lifestyle, and Health Indicators in Individuals aged 50 years and older: Prospective Cohort

Research Article of International Journal of Aging Research Incidence of Cognitive Decline and Association with Changes in Sociodemographic, Lifestyle, and Health Indicators in Individuals aged 50 years and older: Prospective Cohort Maria Cristina Umpierrez Vieira1, 2, Douglas Fernando Dias1, Maira Sayuri Sakay Bortoletto1, Ana Maria Rigo Silva1, Marcos Aparecido Sarria Cabrera*3 1Public Health Department, State University of Londrina (UEL), Londrina (Paraná), Brazil; 2Nursing Department, State University of the Midwest of Paraná (UNICENTRO), Guarapuava (Paraná), Brazil; 3Internal Medicine Department, State University of Londrina (UEL), Londrina (Parana), Brazil Objectives: To identify the incidence of cognitive decline (CD) in an urban community-dwelling population aged 50 years and older in a 4-year follow-up period and its prospective association with sociodemographic factors, lifestyle and health conditions as well as with changes in these factors. Methods: This is a prospective cohort with a representative sample of people aged 50 years and older (n = 206) from Cambé, PR, where baseline data collection occurred in the year 2011 and the follow-up occurred in 2015. The incidence of CD was the outcome of this study, and its evaluation occurred through the Mini-Mental State Examination. Results: The incidence of CD was 13.1% over the 4 years of follow-up, and adjusted Poisson regression models (sex, age and age range) showed that this condition was prospectively associated with depression (adjusted relative risk (RR) = 3, 50, 95% CI = 1.65-7.43). When analyzing the effect of sociodemographic factor changes on CD, it was verified that the risk of CD was 2.86 times higher among the group that stopped having a companion in the 4 years of follow-up when compared to the group that maintained a companion in that same period, independent of confounding factors. Conclusion: The data suggest that the CD process begins before the age of 60 y and that aggravation is ...

The Neuro Engraftment and Neuroregenerative effects of Hydrogen Sulphide Donor, Intracerebral MSCs, Ginko Biloba and Kefir in Attenuating Neuropathological hallmarks of Lipopolysaccharide induced Alzheimer’s disease Rat models

Research Article of International Journal of Aging Research The Neuro Engraftment and Neuroregenerative effects of Hydrogen Sulphide Donor, Intracerebral MSCs, Ginko Biloba and Kefir in Attenuating Neuropathological hallmarks of Lipopolysaccharide induced Alzheimer's disease Rat models Mai M.Anwar1, Ola S.M.Ali2, Laila A. Rashed.3, Badawi A.M.1, Nadia A.Eltablawy1 1Department of Biochemistry, National Organization for Drug Control and Research (NODCAR), Giza 12511, Egypt. 2Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, cairo 11311, Egypt. 3Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza 12511, Egypt. Background: Memory disorders have been characterized by being a devastating long term incurable diseases with a huge social impact in addition to a diminished efficient available medical treatments. Deep Brain stimulation via using neuroprotective inducers for treatment of brain structure degenerative diseases such as Alzheimer’s disease (AD) can be considered as being a promising successful therapy due to its various targets and underlying mechanisms for improving brain dysfunction. Objectives: The main aim of this study is to suggest therapeutic protocol having the potentials for restoring normal neurons diverse population and modifying neuropathological deposited hallmarks including both positive and negative lesions. Materials and Methods: Rats were divided into nine groups: (G1) control ;(G2) rats received LPS as a method of inducing nongenetically manipulated AD;(G3)AD rats received NaHS;(G4) AD rats received MSCs intracerebrally;(G5) AD rats received MSCs+NaHS;(G6)AD rats received kefir+GB;(G7)AD rats received MSCs+kefir+GB;(G8)AD rats received NaHS+kefir+GB; (G9) AD rats received MSCs+NaHS+kefir+GB. Results: AD induction resulted in down-regulation of CBS expression and GSH brain tissue level accompanied with overexpression in amyloid-β protein, MAPK, tau protein, ACAT expression and MDA brain tissue level in addition to elevated caspase-3 serum level. Conclusion: The implantation of amyloid reliving therapy that do have a wide clinical impact if initiated at benign plaques stage before irreversible brain damage occurs. The following effects have ...

Alzheimer´s Disease and Age-related Macular Degeneration could simultaneously be treated or prevented with a single therapeutic intervention

Research Article of International Journal of Aging Research Alzheimer´s Disease and Age-related Macular Degeneration could simultaneously be treated or prevented with a single therapeutic intervention Arturo Solís Herrera, MD, PhD. Human Photosynthesis® Research Centre Aguascalientes2000, México Alzheimer ´s diseases becomes the most common type of dementia in the world. There is more of 5.4 million AD patients in America, more than 6 million patients in China, and 35.6 million patients worldwide. AD and other dementias worldwide will increase to 67.5 million by 2030 and 115.4 million by 2050. In the aging population, two of the most common neurodegenerative diseases, AD and AMD, could simultaneously treated or prevented with single therapeutic intervention. Keywords: AD, AMD, Melanin, hydrogen, energy, glucose ...

Depression and suicidal ideation in institutionalized elderly in Recife

Research Article of International Journal of Aging Research Depression and suicidal ideation in institutionalized elderly in Recife Evandro Valentim da Silva; Carla Andrea de Moura; Carolina Silva de Aleluia; José Marcio Nogueira da Silva; Fálba Bernadete Ramos dos Anjos; Eliane Helena Alvim de Sousa This study aimed to analyze the disorders of depression and suicidal ideation in a population of institutionalized elderly in the city of Recife - PE. To measure the phenomena under study two standardized scales were adopted, the BECK SCALE FOR Suicide Ideation (BSI) and the Geriatric Depression Scale (GDS / GDS). The collected data were entered into a database, and statistical procedures performed using the Statistical Package for Social Sciences (SPSS) version 13.0 for Windows. After analysis of the data was possible to show that with the EDG, 48% of the interviewed elderly population is with some degree of depression. It was observed higher scores on the BSI scale for women. Among the elderly depression affects more the age less than 80 years, suicidal ideation was little evident in the population studied, being more related to female. Keywords: Geriatric Depression. suicidal ideation in the elderly. depression in institutionalized elderly ...

Dr. Jong In Kim
Professor and Chairman, Institute for Longevity Sciences, Wonkwang University, South Korea

Dr. Emmanuel ANDRES
Professor of Internal Medicine; Head of the Department of Internal Medicine, Internal Medicine in the University hospital of Strasbourg, University of Strasbourg, France

Dr. Karen V. Harper-Dorton
Professor, School of Social Work, West Virginia University, West Virginia 26506

Dr. Ferhan SOYUER
Professor, Nuh Naci Yazgan University Faculty of Health Sciences, Kayseri/Turkey

Dr. Akira Sugawara
Professor, Department of Molecular Endocrinology,Tohoku University Graduate School of Medicine, Miyagi, Japan

Dr. Francisco López-Muñoz

Professor of Pharmacology, Director of International Doctorate School, Chairman of the Research Ethics Committee, and Assistant Director of Academic Staff at Camilo José Cela University, and Research Fellow at “Hospital 12 de Octubre” Research Institute (Madrid, Spain), and Portucalense Institute of Neuropsychology and Cognitive and Behavioral Neurosciences (INPP), Universidade Portucalense Infante Dom Henrique 

Dr. Diego Lacono
Associate Professor, Biomedical Sciences, Biomedical Research Institute of New Jersey, NJ 07927

Dr. Ya-Lie Ku
Associate Professor, College of Nursing, Department of Nursing, Fooyin University

Dr. Dorina Lauritano
Assistant Professor, Faculty of Medicine – University of Milano”Bicocca”, Monza

Dr. Naohiro Hohashi
Professor, Division of Family Health Care Nursing, Department of Nursing, Graduate School of Health Sciences, Kobe University

Dr. Bechor Zvi Aminoff
Professor, Geriatric Division, The Chaim Sheba Medical Center, Tel Hashomer, Israel

Dr. Lia Ginaldi
Full Professor, Department of Clinical Medicine, Public Health, Life and Environment Sciences University of L’Aquila

Dr. Ufuk Çakatay
Professor, Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, Turkey

Dr. Fabio Monzani
Professor, Department of Clinical & Experimental Medicine, Section of Geriatrics and Gerontology, University Hospital of Pisa, Italy

Dr. Robert L. Clegg
Professor/Faculty Head, Health Administration Programs

Dr. Ian Martins
Centre of Excellence for Alzheimer’s Disease Research and Care Sarich Neuroscience Research Institute, Edith Cowan University, Australia

Dr. Khue Vu Nguyen
Full Project Scientist, University of California, San Diego, CA (U.S.A.), School of Medicine, Departments of Medicine and Pediatrics

Dr. Kim L. Stansbury
Associate Professor/Director of MSW Program, Department of Social Work, North Carolina State University, Raleigh, North Carolina

Dr. Putilov, Arcady A.
Chief researcher, Research Institute for Molecular Biology and Biophysics, Novosibirsk, Russia

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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International Journal of Aging Research is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Aging Research (Indexing details).

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