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Colon Irrigation Bowel Preparation Supports Multiple Clinical Benefits in Over 8,000 Patients

Research Article of Open Journal of Gastroenterology and Hepatology Colon Irrigation Bowel Preparation Supports Multiple Clinical Benefits in Over 8,000 Patients Chris Godell1, Robert Frachtman1, Christopher Peake1,2, Richard M. Sperling1, Benjamin D. Havemann1, John J. Ziebert1* 1Austin Gastroenterology, Austin, TX, USA. 2HCA Healthcare, Austin, TX, USA. This retrospective clinical study evaluates an FDA-cleared high-volume colon irrigation bowel prep (BP) for colonoscopy, performed under standard operating procedures with Austin Gastroenterology (AG, Austin, TX). Patient related outcomes in 8,364 procedures, prescribed by 33 physicians in 4.5 years, demonstrated no serious adverse events and excellent satisfaction rates. The high level of adequacy using this BP far exceeds national benchmarking thresholds for adequate colon preparations. Adequacy rates remain high even when considering poor BP risk factors and patient noncompliance with ancillary pre-preparation regimens. Our analysis demonstrates that this colon irrigation BP has excellent Boston bowel preparation scores (BBPS), associated with high-level adenoma detection rates (ADR) and sessile serrated polyp (SSP) detection rates. ADR and SSP are inversely related to the patient’s post-colonoscopy interval colorectal cancer (CRC) risk, and are similarly related to an inadequate BP. Both modeling data and performance characteristics strongly suggest that this colon irrigation BP is highly safe, effective, and will reduce the costs and risks related to inadequate BP. This, accordingly, leads to significantly improved quality outcomes, savings to the healthcare systems, and a reduction of the patient’s burden. Keywords: colonoscopy; colon preparation; colonoscopy quality; ADR; SSP; CRC ...

A pilot study for using high-volume colon irrigation bowel preparation for colon capsule endoscopy shows feasibility of adequate bowel prep with high patient satisfaction

Research Article of Open Journal of Gastroenterology and Hepatology A pilot study for using high-volume colon irrigation bowel preparation for colon capsule endoscopy shows feasibility of adequate bowel prep with high patient satisfaction David J. Hass MD FACG1*, William Stassen MD2, Dawn B. Burleson RN MBA CRA3, Gavriel D. Meron MBA3, Orly Levitan PhD3, David A. Johnson MD MACG FASGE MACP4 1Yale University, Hamden, CT, USA; 2Austin Gastroenterology, Austin, TX, USA; 3Hygieacare Inc., Norfolk, VA, USA; 4Eastern VA Medical School, Norfolk, VA, USA. A feasibility study was performed to test a bowel preparation (BP) method that would improve patients’ experience of colon capsule endoscope (CCE) while retaining clinical adequacy. Specifically, the use of high-volume colon irrigation with the Hygieacare® System, HygiPrep™, was tested in conjunction with Medtronic’s PillCam COLON 2 Capsule. This prospective, single-center, and IRB-approved study evaluated HygiPrep use prior to the PillCam COLON 2 procedure instead of the standard split-polyethylene glycol-electrolyte (PEG) oral prep. The study was performed at Austin Gastroenterology (Austin, TX), and all capsule video files were forwarded to a Central Reader to evaluate and compile a study report. Six of the seven (86%) subjects completed both the HygiPrep and PillCam COLON 2 exams and were graded as excellent, good, or adequate by the Central Reader. Patients’ feedback reported positive satisfaction scores for both the HygiPrep and the PillCam COLON 2 procedures. These results support our hypothesis that HygiPrep was as effective as Split-PEG BP. We suggest that the HygiPrep, is a suitable BP for CCE, providing adequate BP and high patient satisfaction. Keywords: Capsule Endoscopy; Colon Capsule Endoscopy; Colon Preparation; Colonoscopy Quality; HygiPrep; PillCam; COLON 2 ...

Ultrafiltration (UF) Effectiveness on intradialytic hypertension (IDH) in chronic hemodialysed patients in a nephrology unit in Dakar: UF-IDH clinical trial

Research Article of Global Journal of Urology and Nephrology Ultrafiltration (UF) Effectiveness on intradialytic hypertension (IDH) in chronic hemodialysed patients in a nephrology unit in Dakar: UF-IDH clinical trial Ba Bacary 1, Faye Moustapha 1, Keita Niakhaleen 1, Lemrabott Ahmed Tall 1, Seck Sidy Mohamed 2, Faye Maria 1, Mbengue Mansour 1, Diagne Seynabou 1, Ba Mamadou Aw 1, Dieng Ahmed 1, Kane yaya 3, Diouf Boucar 1, Niang Abdou 1, Ka Elhadji Fary 1 1Department of Nephrology, Dialysis and Renal Transplantation of Aristide Le Dantec University Hospital, Cheikh Anta Diop University, Dakar, Senegal. 2Department of nephrology and dialysis of the Military Hospital of Ouakam, Gaston Berger University of Saint Louis, Senegal. 3Departement of nephrology and dialysis of the regional hospital of Ziguichor, Assane Seck university of Ziguinchor, Senegal. Introduction Progressive ultrafiltration (UF) could improve IDH. The aim of this work was to evaluate the effectiveness of progressive UF in the management of IDH. Methods This randomized clinical trial in two groups: interventional group A (UF, n = 12) and control group B (n = 12), was conducted in chronic hemodialysis patients with IDH. A first phase of cross-sectional collection of BP before and after dialysis, during 2 weeks, made it possible to obtain this cohort of 24 patients. A progressive decrease in basal weight of 0.25 kg per session as a function of hemodynamic tolerance was achieved in group A. The primary endpoint, the proportion of patients with disappearance of IDH, was assessed at baseline end of the 4th and 8th week. Results At the 4th week, the IDH disappeared in 83.3% and 41.7% of the patients of the group A and B respectively with a hazard ratio (HR) at 0.29; IC 95 = [0.14-0.59]; p = 0.035. At the 8th week, the IDH was missing in 72.7% and ...

Research status and development direction of controlling factors of graphite mineralization in coal measures

Research article of American Journal of Scientific Research and Essays Research status and development direction of controlling factors of graphite mineralization in coal measures Tian Yuan1*, Li Xiaobo2, Gong Liubing1, Li Haihua1, Yang Rui1, Xu Bohui1 1School of Earth Science and Engineering, Hebei University of Engineering, Handan, Hebei 056038, China. 2Shandong No.5 Geo-mineral Prospecting Institute, Tai'an, Shandong 271000, China. Coal-measure graphite mineralization control is affected by many factors. In order to explore the ore-forming control factors and influence mechanism, the paper comprehensively analyzes the influence and mechanism of each factor from five aspects of coal rock composition, coal grade, temperature, pressure and mineralizer, combined with geological examples. The results show that in the process of graphite mineralization in coal measures, the components of coal and rock have the ability of graphitization, but the higher the degree of metamorphism of coal as carbon source, the higher the degree of graphitization of products, the higher the ore-forming temperature, and the higher the degree of graphitization. The development of tectonic movement promotes the graphitization, but the degree of graphitization is different and complicated due to the stress dissipation. Different minerals in coal have different effects on graphite mineralization in coal measures, and its mechanism needs to be further explored. Finally, it is pointed out that the research direction of coal series graphite lies in the different graphitization mechanism of the same rank coal and the different influence mechanism of different minerals in coal. Fund Project: Study on the structural order degree of cryptocrystalline graphite and its ore-forming controlling factors in coal measures of Hebei natural fund (D2019402055). Keywords: Coal series graphite; Metallogenic mechanism; Graphitization ...

Nutritional potential of anti-anemic drinks based on Manihot esculenta L. or Graptophyllum pictum L. leaf extracts consumed in Yaoundé Cameroon

Research Article of International Journal of Food and Nutrition Research Nutritional potential of anti-anemic drinks based on Manihot esculenta L. or Graptophyllum pictum L. leaf extracts consumed in Yaoundé Cameroon 1Djuikwo Nkonga Ruth Viviane*, 1Djeumen Kouamen Aurélie Ludovine, 2Yadang Germaine, 2Panyoo Emmanuel, 1Mananga Marlyne, 1Saha Brice, 1Djouhou Fowe Michelle Carole, 1Fokou Elie 1Laboratory for Food Sciences and Metaboism, University of Yaoundé I, Yaoundé, Cameroon; 2Department of Food Sciences and Nutrition, National School of Agro-Industrial Sciences, University of Ngaoundéré, Cameroon Anemia is a global public health problem. In Cameroon, the most vulnerable to anemia are children under 5 years of age (60%) and pregnant women (40%). To reduce prevalence of anemia, several approaches have been adopted, including promoting the production and consumption of iron-rich foods/products. The objective of this work was to study the nutritional potential of anti-anemic drinks based on extracts from the leaves of either Manihot esculenta or Graptophyllum pictum consumed by the populations of the city of Yaoundé in Cameroon. Macronutrient contents were determined using the standard A.O.A.C. methods, while mineral contents were analyzed using the atomic absorption spectrophotometry. Bioactive compounds such as total polyphenols, flavonoids, and saponins were analyzed. Vitamin C was determined by the 2,6 dichlorophenol indophenol spectrophotometric method (DCPIP) and the contents of anti-nutrients (tannins, phytates, oxalates, saponins, hydrocyanic acid) quantified using standard methods. The results of these analyses show that the mean protein contents in the studied anti-anemic drinks ranged from 0.64 ± 0.08 g/100 mL to 1.84 ± 0.02 g/100 mL (M. esculenta drink); and 0.25 ± 0.01 g/100 mL (G. pictum drink). Sugar contents ranged from 0.30 ± 0.02 g/100 mL to 0.45 ± 0.01 g/100 mL (M. esculenta drink), and 0.29 ± 0.01 g/100 mL (G. pictum drink). As concerns iron contents, and vitamin C contents were inversely proportional across M. esculenta ...

The predictive power of approach and autonomous goal motivation for work engagement among public sector employees

Research Article of International Journal of Psychological Research and Reviews The predictive power of approach and autonomous goal motivation for work engagement among public sector employees Christian Ehrlich Oxford Brookes University, UK This paper compares the relative predictive power of approach goal motivation and autonomous goal motivation for work engagement among public sector employees. To do so, it employs the goal-striving reasons framework within which people’s approach goal motivation is measured as well as the self-concordance theory which measures people’s autonomous goal motivation. Findings are based on cross-sectional and longitudinal data of 132 public service employees at time 1 and 78 employees at time 2. Overall, the results show, using multiple regression analysis, that approach goal motivation significantly predicts work engagement whereas autonomous goal motivation is not a significant predictor of work engagement. On an individual goal-reason level, a similar picture emerges. Pleasure and altruism, the two approaching goal-striving reasons, are descriptively more strongly correlated with work engagement than their comparable self-concordance reason of intrinsic and identified goal motivation. When testing the predictive power of pleasure and altruism with intrinsic and identified goal motivation simultaneously, using multiple regression analysis, pleasure remains the only significant predictor of work engagement at time one and time two. The findings suggest that approach motivation is a stronger predictor of work engagement than autonomous goal motivation for public sector employees. Additionally, the findings also indicate that pleasure is more important for the work engagement of public sector employees than their altruistic goal motivation on an individual goal-reason level. Keywords: goal-striving reasons framework, self-concordance, work engagement, public sector employees ...