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IMPACT OF TUMOR SIZE ON DEPTH OF INVASION AND NUMBER OF LYMPH NODES INFILTRATION IN ESOPHAGEAL CANCER

Research Article of American Journal of Surgical Research and Reviews Impact of tumor size on depth of invasion and number of Lymph nodes infiltration in esophageal cancer Ahmed S Elgammal, MD1*, Ihab S Ahmed MD2, Walla Abdelgawad,MD3, Essam Elshiekh, MD4 1General surgery department, Menofia faculty of medicine, Menofia University, Egypt. 2Surgical oncology department, NCI, Cairo university, Egypt. 3Pathology department, Suez faculty of medicine, Suez university, Egypt. 4Surgical oncology department, Tanta Cancer Center, Egypt. Introduction: Esophageal cancer (EC) is one of the deadliest malignancies worldwide and is often diagnosed in advanced stages. It is the 8th most common cancer in the world and is the 6th most common cause of cancer related deaths, having a 5-year survival rate of less than 20% despite advances in treatment. It has a poor prognosis due to the late diagnosis and the lack of early presenting symptoms. In the United States, stage IV is the most common stage at the time of diagnosis. Methods: Eighty-seven fit patients were recruited for this multi-institutional clinical prospective study in the period from the start of January 2014 to the end of December 2020, diagnosed as cancer esophagus in by endoscopic biopsy and underwent surgical treatment according to stage at the centers participating in this study. Results: In pre-operative biopsy, Adenocarcinoma was diagnosed in 39/87 cases (44.8%) distributed as (5 in GEJ and 34 diagnosed in lower esophagus) while squamous cell carcinoma (SCC) diagnosed in 48/87 cases (55.2%) distributed as (28 in lower part, 10 in middle part and 9 in upper esophagus respectively) and only one case out of 87 cases diagnosed as undifferentiated carcinoma of lower esophagus. We found significant association between the increased tumor size and the increase depth of invasion and thenumber of harvested lymph nodes. Conclusion: As the tumor size increased (cutoff point 3cm),  ...

A shift in surgical management of perforated jejunal-ileal diverticulitis? Two case reports

Case Report of International Journal of Case Reports A shift in surgical management of perforated jejunal-ileal diverticulitis? Two case reports Wei Liu, MD1,  Ali Darehzereshki, MD1,  Michael Matsuura, MD2, Christopher You, MD2 1Department of Surgery, MedStar Health Baltimore, Baltimore, Maryland. 2Department of Surgery, MedStar Franklin Square Medical Center, Baltimore, Maryland. Small bowel diverticular disease is usually asymptomatic, but complicated small bowel diverticular disease can present as an acute abdomen, manifesting as diverticulitis, perforation, abscess, obstruction or bleeding. Due to the rarity of the disease, very few studies have been conducted on complicated small bowel diverticular disease. Therefore, there are no clear guidelines on management. General peritonitis remains the best indication for surgical management due to its correlation with high mortality and prolonged hospital stay. Traditionally, perforated small bowel diverticular disease is managed with exploratory laparotomy, primary bowel resection and anastomosis regardless of acute presentation. However, more recent studies demonstrated a trend towards conservative or less invasive surgical management. Here, we report two perforated small bowel diverticulitis cases at our institution that underwent different management and had different outcomes. Keywords: surgical management; perforated jejunal-ileal diverticulitis ...

Epidemiology and Risk Factors for Hepatitis C Infection in Malaysia: A Narrative Review

Review Article of Open Journal of Gastroenterology and Hepatology Epidemiology and Risk Factors for Hepatitis C Infection in Malaysia: A Narrative Review Mohd Azri Mohd Suan1,2, Salmiah Md Said1*, Ahmad Zaid Fattah Azman1, Muhammad Radzi Abu Hassan2,3 1Department of Community Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. 2Clinical Research Centre, Hospital Sultanah Bahiyah, KM 6, Jalan Langgar, 05460 Alor Setar, Kedah, Malaysia. 3Department of Medicine, Hospital Sultanah Bahiyah, KM 6, Jalan Langgar, 05460 Alor Setar, Kedah, Malaysia. Hepatitis C infection is a growing public health issue in Malaysia. A large number of people living with hepatitis C virus (HCV) are unaware of the infection. The treatment complexity warrants a comprehensive understanding of this infectious disease to support planning for strategies to reduce the burden of disease associated with hepatitis C. This study aimed to summarise the epidemiology and risk factors attributable to hepatitis C acquisition in Malaysia based on local published articles. Published articles related to epidemiology and risk factors for hepatitis C infection in Malaysia between 2005 and 2017 were searched through several online databases. Related information from the Ministry of Health official website was also compiled. An increasing trend in the incidence and mortality rate of hepatitis C infection is noted over the last decades. In 2009, the national prevalence of people infected with HCV was approximately 2.5%, with the prevalence rate varying according to different high-risk groups. The most common genotypes reported are genotypes 3 and 1. Frequently reported risk factor for HCV acquisition is injection drug use. Other identified risk factors are being a blood product recipient, haemodialysis patient or participant in high-risk sexual activity. Nevertheless, a considerable number of patients had no known risk factors. The prevalence and burden of HCV-related disease are substantial and can be attributed ...

KYRLE’S DISEASE (KD): “AN UPDATE WITH REVIEW OF LITERATURE” A SPONGEBOB SKIN PORES SIMULATION

Research Article of American Journal of Surgical Research and Reviews Kyrle’s disease (KD): "An Update with review of literature" A Spongebob Skin pores simulation Dr. UwaisRiazUlHasan* M.Med, Dr. Khathija Hasan M.Med, Dr. Victor Effiong Obong M.B.B.Ch, MWACS, Dr. Okorie Christian Chima M.B.BCh, FWACS, FMCS, Dr. Abdul Aziz Al Nami M.B.B.S, Dr. Abdullah Abdulmonem AlZarra M.B.B.S, Dr. Hassan A Al Wtayyan M.B.B.S, Dr. Ali Ibrahim AlShaqaqiq M.B.B.S, Dr. Mohammad AbdulMajeed Alghadeer M.B.B.S, Dr. ShehlaRiazUlHasan Phd, Dr. Moath AbdulAziz AlMasoud2 M.D, Dr. Noura Al Dossary1 1Department of General Surgery, Al Omran General Hospital, Al Hassa, Kingdom of Saudi Arabia. 2Head of department, 1Hospital Director Al Omran General Hospital. Kyrle’s disease (KD) is a Chronic skin condition first described by Austrian pathologist Josef Kyrle in 1916. Kyrle referred to this condition as hyperkeratosis follicularis & parafollicularis in cutem penetrans. These diseases are characterized by the phenomenon of transepidermal elimination of denatured dermis an acquired form of perforating dermatosis [14]. It is characterized by keratotic crater plugs that develop in hair follicles penetrating the epidermis and extending into the dermis [4]. This trans epithelial migration and elimination of proteinaceous components is associated with systemic disorders like renal, liver diseases, chronic heart failure and diabetes mellitus. We present two case scenarios of a young Males with multiple chronic papular eruptions along with a review of literature for Kyrle’s disease (KD). Keywords: Kyrle’s disease (KD), metabolic disease, perforating dermatoses, primary disorder ...

NECROTIZING FASCIITIS AT THE EXTREMITIES AND ITS MANAGEMENT

Research Article of American Journal of Dermatological Research and Reviews Necrotizing fasciitis at the extremities and its management Hatim ABID1*, Mohammed EL IDRISSI1, Abdelhalim EL IBRAHIMI1, Abdelmajid ELMRINI1, Nissrine AMRAOUI2, Sara ELLOUDI2, Hanane BAYBAY2, Fatima Zahra Mernissi2 1Department of osteoarticular surgery B4, HASSAN II teaching hospital, Fes, Morocco. 2Department of dermatology HASSAN II teaching hospital, Fes, Morocco. We report in the light of a literature review the results of 28 patients treated for Necrotizing Fasciitis (NF) at the extremities between 2012 and 2017 with a view to a prospective study with longer following up and a greater number of patients. Keywords: Necrotizing Fasciitis; extremities; treatment ...

Measuring the Effectiveness of Deradicalisation: The Development of MIKRA Risk Assessment

Research Article of American Journal of Psychiatric Research and Reviews Measuring the Effectiveness of Deradicalisation: The Development of MIKRA Risk Assessment Zora A. Sukabdi University of Indonesia. Instruments for identifying risk of terrorist offenders could help counterterrorism practitioners define parameters of effective rehabilitation and detect a change in risk level of offenders before and after treatment. This study aims to develop Motivation-Ideology-Capability Risk Assessment, known as MIKRA, to examine the level of risk of terrorist offenders. The study involved Indonesian counterter-rorism experts and practitioners for examining the construct validity of MIKRA and terrorist offenders at a maximum-security prison for analysing the external and criterion-related validity. External validity was implemented by comparing offenders’ MIKRA scores with their risk categories reported by Counterterror-rism Special Task Force. Internal consistency reliability (Cronbach’s Alpha) was also applied to examine MIKRA’s psychometric properties. The results indicate alpha reliability α= 0.933. Furthermore, offenders’ MIKRA scores are correlated significantly with categories of risk released by the official, but not correlated with the non-offenders’ scores. This means MIKRA is valid to investigate risks of terrorist offenders. Keywords: Measuring the Effectiveness; Deradicalisation; MIKRA Risk Assessment ...